Reflux esophageal stricture—a review of 30 years' experience in children

Pearson, Erik G.; Downey, Earl C.; Barnhart, Douglas C.; Scaife, Eric R.; Rollins, Michael D.; Black, Richard E.; Matlak, Michael E.; Johnson, Dale G.; Meyers, Rebecka L.

doi:10.1016/j.jpedsurg.2010.08.033

Cited by 40 publications

(27 citation statements)

References 16 publications

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“…[64][65][66][67][68][69][70][71][72][73] Through-the-scope balloon dilation is possible in larger infants and children, but there are no dilation balloons that fit through a 2-mm channel. Balloon dilation can be performed in infants who will not tolerate a standard gastroscope by using a guidewire and over-the-wire dilation balloons (eg, biliary dilation balloons) under fluoroscopic guidance.…”

Section: Therapy For Esophageal Stricturesmentioning

confidence: 99%

Equipment for pediatric endoscopy

Barth

Banerjee²,

Bhat³

et al. 2012

Gastrointestinal Endoscopy

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Section: Therapy For Esophageal Stricturesmentioning

confidence: 99%

Equipment for pediatric endoscopy

Barth

Banerjee²,

Bhat³

et al. 2012

Gastrointestinal Endoscopy

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“…Literature suggests that acid exposure might give rise to fibrosis in wound healing (16), which is why we measured the pH at autopsy in piglets 3 and 4. In order to prevent reflux-associated distress, we introduced Nexium enterally for piglets 3-6.…”

Section: Discussionmentioning

confidence: 99%

“…In order to prevent reflux-associated distress, we introduced Nexium enterally for piglets 3-6. Literature suggests that acid exposure might give rise to fibrosis in wound healing (16), which is why we measured the pH at autopsy in piglets 3 and 4. As it showed a pH of 4 to 5, we increased the dosage of Nexium.…”

Section: Discussionmentioning

confidence: 99%

Macrophage Phenotype Is Associated With the Regenerative Response in Experimental Replacement of the Porcine Esophagus

et al. 2015

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A porcine model for bridging circumferential defects in the intrathoracic esophagus has been developed in order to improve the treatment of children born with long-gap esophageal atresia. The aim of this study was to identify factors beneficial for tissue regeneration in the bridging area in this model and to describe the histological progression 20 days after replacement with a silicone-stented Biodesign mesh. Resection of 3 cm of intrathoracic esophagus and replacement with a bridging graft was performed in six newly weaned piglets. They were fed through a gastrostomy for 10 days, and then had probe formula orally for another 10 days prior to sacrifice. Two out of six piglets had stent loss prior to sacrifice. In the four piglets with the stent in place, a tissue tube, with visible muscle in the wall, was seen at sacrifice. Histology showed that the wall of the healing area was well organized with layers of inflammatory cells, in-growing vessels, and smooth muscle cells. CD163+ macrophages was seen toward the esophageal lumen. In the animals where the stent was lost, the bridging area was narrow, and histology showed a less organized structure in the bridging area without the presence of CD163+ macrophages. This study indicates that regenerative healing was seen in the porcine esophagus 20 days after replacement of a part of the intrathoracic esophagus with a silicone-stented Biodesign mesh, if the bridging graft is retained. If the graft is lost, the inflammatory pattern changes with invasion of proinflammatory, M1 macrophages in the entire wall, which seems to redirect the healing process toward scar formation.

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“…It is usually repaired soon after birth with a postoperative survival rate of 95%, which indicates that the principal burden of the disease is accounted for by post-M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT operative morbidity. Dysphagia occurs frequently in infants and children with a history of oesophageal atresia repair; indeed, in the early postoperative period, this symptom is most commonly related to an anastomotic stricture, the development of which is related to anastomotic tension and seems to increase with gap length as well as with the presence of gastro-oesophageal reflux [106][107][108]. Strictures early in the life of these patients respond well to dilatations [109,110].…”

Section: Oesophageal Atresia and Eosinophilic Oesophagitismentioning

confidence: 99%

Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia

Lucendo

2015

Best Practice & Research Clinical Gastroenterology

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Reflux esophageal stricture—a review of 30 years' experience in children

Cited by 40 publications

References 16 publications

Equipment for pediatric endoscopy

Equipment for pediatric endoscopy

Macrophage Phenotype Is Associated With the Regenerative Response in Experimental Replacement of the Porcine Esophagus

Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia

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