Reflux oesophagitis in Italy (Diomede project)

Baldi, Fabio; Cavoli, C.; Solimando, Riccardo; Bianco, M.A.; Cipolletta, Livio; Costamagna, Guido; Passaretti, Sandro

doi:10.1016/j.dld.2007.12.018

Cited by 6 publications

(2 citation statements)

References 20 publications

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“…A recent cross-sectional case-control study involving 7,078 participants demonstrated an association between metabolic syndrome and EE (26); this study showed that obesity (in particular visceral fat) and elevated triglycerides represented independent factors for EE. However, a link between BMI and EE was not confirmed in a recent Japanese prospective study (36) or in a multicenter Italian observational study (37). A large population-based study in Sweden revealed that there was no association between BMI and the severity or duration of GERD symptoms (24).…”

Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study on the Risk Factors for Erosive Esophagitis in Young Adults

et al. 2012

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Objective To investigate the impact of metabolic and lifestyle factors on erosive esophagitis in young adults. Methods A total of 5,069 people under the age of 40 years old were enrolled in a medical survey at our institute. People with a previous history of upper gastrointestinal tract surgery were excluded, as were individuals taking medication for reflux symptoms, peptic ulcers, or malignancies. Independent and significant predictors affecting the presence of erosive esophagitis were determined by multivariate analysis. Results A total of 4,990 participants (male/female; 3,871/1,119, age; 33.9±3.9 years) were eligible. A total of 728 participants (14.6%) had erosive esophagitis. Male gender and increasing age were independent predictors for increased prevalence of erosive esophagitis (odds ratio=2.242 and 1.045. 95% confidence interval= 1.613-3.117 and 1.019-1.072; p<0.001 and 0.001, respectively). Moderate-to-heavy alcohol consumption, light-to-moderate-to-heavy smoking, hypertension, hyperglycemia, and hiatal hernia each significantly and independently increased the risk for erosive esophagitis (odds ratio=1.499, 1.398, 1.353, 1.570, 1.884, 1.297, 1.562, and 3.213. 95% confidence interval=1.181-1.903, 1.040-1.880, 1.094-1.675, 1.250-1.971, 1.307-2.716, 1.074-1.566, 1.063-2.295, and 2.712-3.807; p=0.001, 0.027, 0.005, <0.001, 0.001, <0.001, 0.007, 0.023, and <0.001 respectively). Helicobacter pylori infection decreased the risk for erosive esophagitis (odds ratio= 0.575, 95% confidence interval =0.436-0.759 p<0.001). Neither body mass index nor waist girth conferred increased risk of erosive esophagitis after adjusting for potential confounding factors. Conclusion Risk of erosive esophagitis in Japanese young adults was not increased by obesity, but it was increased by hiatal hernia and metabolic and lifestyle profiles including hypertension, hyperglycemia, alcohol consumption and smoking.

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Section: Discussionmentioning

confidence: 99%

A Cross-Sectional Study on the Risk Factors for Erosive Esophagitis in Young Adults

et al. 2012

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“…У представителей различных этнических групп Северной Америки ассоциированный с гастроэзофагеальным рефлюксом эзофагит составляет 23%. При наличии симптомов диспепсии эрозивное повреждение слизистой пищево- [7,12,14,18,[23][24][25]27].…”

Section: Introductionunclassified

Prevalence of erosive esophagitis and peptic esophageal strictures

Vasilevskiy

Skurihin

Luft

et al. 2015

Khir. Z. im. N.I. Pirogova

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Gastroesophageal reflux disease is a widespread among population in economically developed countries including Russia. It was analyzed the results of 34 903 endoscopic examinations of upper gastrointestinal tract in ethnically and socially homogeneous population of Leningrad region with symptoms of gastric dispepsia. Procedures were performed for the period 2007-2013. Prevalence of erosive esophagitis was 4.9%. Peptic esophageal strictures due to chronic reflux-associated inflammation were revealed in 0.2% of examined patients (3.7% of patients with erosive esophagitis). Obtained data allow to considergastroesophageal reflux disease as a socially significant problem in Russia requiring close attention and further study.

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