Refractive and corneal responses of young myopic children to short-term orthokeratology treatment with different compression factors

Wan, Kin; Lau, Jason K.; Cheung, Sin Wan; Cho, Pauline

doi:10.1016/j.clae.2019.10.134

Cited by 22 publications

(36 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12,13 Hence the difference in peripheral thickness changes could be due to differences in ortho-k lens wearing duration. The current study as well as that of Zhang et al, 14 showed no significant thickening at the peripheral cornea, when subjects were required to wear ortho-k lenses for 1 month. Another possible explanation could be the difference of ortho-k lens design, which could lead to a different sized central treatment zone and mid-peripheral reverse zone.…”

Section: Discussionsupporting

confidence: 77%

“…Results on the changes in thickness at the central cornea were also in agreement with previous studies using AS-OCT, which reported significant CCT and CET reduction after commencement of ortho-k lens wear in children. [12][13][14] The magnitude of observed reduction in CET was also comparable. The current study showed that increasing the compression factor by 1.00 D could induce a significantly higher amount of central epithelial thinning (reduction of CET of 6.64 AE 3.29 lm in CCF eyes and 7.98 AE 3.06 lm in ICF eyes).…”

Section: Discussionmentioning

confidence: 57%

“…Kim et al 13 investigated the data from a retrospective cohort and reported thinning in CET of 7.62 AE 3.62 lm in children, who had worn ortho-k lens for 2-4 weeks. Zhang et al 14 observed a rapid reduction in CCT in a group of children after wearing ortho-k lenses, with mean thinning of CET (central 2 mm) of 4.51 lm. Although the exact causes of the changes in corneal thickness after ortho-k lens wear were unclear, morphological changes (compression) in epithelial cells have been reported after short-term ortho-k lens wear, which could contribute to central epithelial thinning.…”

Section: Discussionmentioning

confidence: 98%

“…Children aged 6 to not more than 11 years, with low to moderate myopia (0.50-4.00 D), and anisometropia not more than 1.00 D, were recruited. 14 For the repeatability study, only spectacle wearers were enrolled. For the weekly change study, all subjects were randomly fitted with a pair of ortho-k lenses (Menicon, menicon.com) (Table 1).…”

Section: Subjectsmentioning

confidence: 99%

“…Two studies 12,13 reported significant thickening in the peripheral (5-6 mm) cornea, but one observed insignificant changes. 14 No studies have indicated how corneal thickness changes after the cessation of short-term ortho-k lens wear.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Corneal thickness changes in myopic children during and after short‐term orthokeratology lens wear

Wan

Yau

Cheung

et al. 2021

Ophthalmic Physiologic Optic

Self Cite

View full text Add to dashboard Cite

Purpose: To evaluate thickness changes in the central and mid-peripheral cornea (CCT and mPCT), corneal epithelium (CET and mPET) and stroma (CST and mPST) of myopic children during and after short-term orthokeratology (ortho-k) lens wear, with conventional (CCF, 0.75 D) and increased compression factors (ICF, 1.75 D). Methods: This was a self-controlled case series study. Subjects wore a CCF lens in one eye and an ICF lens in the other. Anterior segment optical coherence tomography images were captured weekly for 1 month during lens wear and for 2 weeks after discontinuing lens wear. CCT and CET (central 3-mm cornea) and mPCT and mPET (within a 4-6 mm diameter annulus) were measured. Stromal thickness (ST) was determined by subtracting epithelium thickness (ET) from corneal thickness (CT). The repeatability of the analytical software was also investigated on age-matched spectacle-wearing subjects (n = 98). Results: Excluding three outliers (>3 S.D.s), the coefficient of repeatability and intraclass correlation coefficients of 98 spectacle-wearing subjects ranged from 2.63 to 4.64 lm and from 0.90 to 0.99, respectively. For the weeklychange study, CCT and CET in both eyes were significantly thinner after lens wear (p < 0.001) and CET thinning in the ICF eyes were significantly higher (p < 0.02). CCT changes were mainly contributed by CET. CST, mPCT, mPET and mPST changes were not significant (p > 0.20) in either eye. CT (all sublayers) rebounded to baseline values 2 weeks after discontinuing lens wear (0.99 > p > 0.12). Conclusions: Significant reductions in CT and ET, but not ST, were observed within 1 month of ortho-k lens wear. Wearing ICF lenses resulted in a higher reduction in CET. Corneal thickness changes were reversible after discontinuing lens wear.

show abstract

Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 98%

Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Corneal thickness changes in myopic children during and after short‐term orthokeratology lens wear

Wan

Yau

Cheung

et al. 2021

Ophthalmic Physiologic Optic

Self Cite

View full text Add to dashboard Cite

show abstract

Diurnal variation of corneal elasticity in healthy young human using air‐puff optical coherence elastography

Chen

Jin

et al. 2021

Journal of Biophotonics

View full text Add to dashboard Cite

Due to the disruption of intraocular pressure (IOP) and central corneal thickness (CCT), diurnal variation in normal young human corneal elasticity is not clear. Using the custom‐built air‐puff optical coherence elastography, one eye of 21 normal subjects is enrolled randomly to measure the central corneal elasticity, IOP, and CCT in different time points within a day. Based on the multi‐level model, the corneal elastic modulus is found to have a linear positive relation with IOP (P < .01) but not CCT (P = .175) and time point (P = .174–.686). A new indicator, corneal elasticity change rate, is proposed to present the magnitude of corneal elasticity change caused by 1 mmHg IOP, which can correct the interference effect of IOP. The results show that the corneal elasticity in the normal young human does not have the characteristics of diurnal variation under IOP control. Furthermore, IOP plays an important role in the corneal elasticity, and corneal elasticity change rate can increase the comparability of results between individuals.

show abstract

Orthokeratology in adults and factors affecting success: Study design and preliminary results

Ren

Yang

Liu

et al. 2020

Contact Lens and Anterior Eye

View full text Add to dashboard Cite

Refractive and corneal responses of young myopic children to short-term orthokeratology treatment with different compression factors

Cited by 22 publications

References 44 publications

Corneal thickness changes in myopic children during and after short‐term orthokeratology lens wear

Corneal thickness changes in myopic children during and after short‐term orthokeratology lens wear

Diurnal variation of corneal elasticity in healthy young human using air‐puff optical coherence elastography

Orthokeratology in adults and factors affecting success: Study design and preliminary results

Contact Info

Product

Resources

About