Refractive error and biometrics of anterior segment of eyes of healthy young university students in Japan

Abstract

To determine the parameters of the anterior segment of eyes that are significantly associated with the refractive error in healthy young Japanese university students. This was a cross-sectional observational study of 229 healthy Japanese university students (men: women,147:82) whose age ranged between 20 to 29 years. Univariate and multivariate linear regression analyses were performed to identify the factors that were significantly correlated with the refractive error. The independent variables included age, sex, axial length, anterior chamber depth, corneal diameter, curvature of anterior surface of cornea, and central corneal thickness. The mean refractive error (spherical equivalent) was −4.1 ± 2.7 diopters (D) with a range of −12.5 to +0.5 D, and the mean axial length was 25.4 ± 1.3 mm with a range of 22.4 to 29.0 mm. Pearson univariate correlation analysis found that the refractive error was significantly and negatively correlated with the axial length (R = −0.82, P < 0.001), deeper anterior chamber (R = −0.30, P < 0.001), and larger corneal diameter (R = −0.21, P = 0.001). Multiple regression analysis showed that the refractive error was significantly associated with a longer axial length (P < 0.001), a deeper anterior chamber (P < 0.001), and a flatter corneal curvature (P < 0.001).The biometric values of the anterior segment of the eyes should make the eye more hyperopic which would reduce the myopia-inducing lengthening of the axial length.

Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography

“…Axial length variation in subjects may induce image size magnification of the OCT-A en face slabs and could therefore affect the VD and FAZ measurements. 35 Because the spherical equivalent, which is correlated with axial length, 36 was not significantly different between our groups (Table 1), we feel that this omission has not affected our measurements.…”

Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT

“…Furthermore, most of the individual findings support previous results in the literature. This includes the ciliary muscle getting larger with age [ 21 , 27 ] in addition to other associations between the lens, anterior chamber angle, and pupil to age or refractive status [ 26 , 29 , 32 – 37 ]. Ultimately, obtaining repeatable and reproducible measurements using a new swept-source AS-OCT that also accounts for known anatomical alterations gives future users confidence in using this device to study biology as well as potentially diagnosing and treating disease.…”

Comment on: The effect of home education on myopia progression in children during the COVID-19 pandemic

“…If one eye is studied and both are eligible, then it should be chosen at random. Most of the previous studies are used for reference [ 2 , 3 ], and in order to avoid the influence of binocular correlation on the results and the introduction of more systematic errors, we choose the right eye from each participant for data analysis. As for correlation analysis, if the basic information of the person, such as age and sex, is reused twice, it may have an impact on the results.…”