Refractive Errors in a Rural Chinese Adult PopulationThe Handan Eye Study

Liang, Yuan Bo; Wong, Tien Yin; Sun, Lan; Tao, Qiu Shan; Wang, Jie Jin; Xiao, Yang; Xiong, Ying; Wang, Ning Li; Friedman, David S.

doi:10.1016/j.ophtha.2009.04.040

Cited by 173 publications

(195 citation statements)

References 31 publications

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“…11 The prevalence of myopia (SE o À 0.5 D) in rural adult Koreans was 20.5%. This was similar to the prevalence found in population-based studies of rural Chinese (18.8%), 10,13 but lower than that observed in populationbased studies of urban Chinese (32.3%), 12 Singapore Chinese (35.0%) 7 and Japanese (41.8%), 11 and higher than that found in a Mongolian population-based sample (17.2%). 9 The prevalence of hyperopia (SE 4 þ 0.5 D) in our study sample was 41.8%.…”

Section: Resultssupporting

confidence: 82%

“…9 The prevalence of hyperopia (SE 4 þ 0.5 D) in our study sample was 41.8%. This was higher than the prevalence figures reported in rural Chinese (20.0 À 23.1%), 10,13 Indonesians (32.1%), 8 Mongolians (32.9%) 9 and Japanese (27.9%), 11 and similar to those of other East Asian samples including Singapore Chinese (35.9%) 7 and urban Chinese (40.0%). 12 The prevalence of high myopia (SE o À 5.0 D or À 6.0 D) in our study sample was 1.2% or 1.0%, respectively.…”

Section: Resultsmentioning

confidence: 42%

“…This was lower than that reported in population-based studies of other East Asians (1.4-6.9%). [7][8][9][10][11][12][13] A general pattern of changes in refractive errors by age group has been observed in previous large-scale epidemiologic surveys. 7,8,11,12 Our results correspond with the results of these studies, which reported that the prevalence of myopia generally follows a bimodal pattern in adults, initially declining with age and then increasing in the higher age groups.…”

Section: Resultsmentioning

confidence: 99%

“…When our results were compared with the overall crude prevalence of refractive errors published in previous population-based surveys, which were undertaken in various races and had similar age distributions and refractive error definitions to those of our study (Table 3), the prevalence of refractive errors in the Korean rural town studied here was slightly different from those found in samples of other races. [3][4][5][6][7][8][9][10][11][12][13] Although the prevalence of myopia varies across studies with no specific pattern observed by ancestral origin in adult populations, 16 myopia is particularly prevalent in East Asia, especially among the Japanese. 11 The prevalence of myopia (SE o À 0.5 D) in rural adult Koreans was 20.5%.…”

Section: Resultsmentioning

confidence: 99%

“…[3][4][5][6][7][8][9][10][11][12][13] Extrapolation from these data has provided clues about the distribution of refractive errors in several geographical populations. The prevalence of refractive errors varies among locally representative adult samples.…”

Section: Introductionmentioning

confidence: 99%

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Refractive errors in a rural Korean adult population: the Namil Study

Yoo

Kim

Park

et al. 2013

Eye

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Purpose To assess the prevalence of refractive errors, including myopia, high myopia, hyperopia, astigmatism, and anisometropia, in rural adult Koreans. Methods We identified 2027 residents aged 40 years or older in Namil-myeon, a rural town in central South Korea. Of 1928 eligible residents, 1532 subjects (79.5%) participated. Each subject underwent screening examinations including autorefractometry, corneal curvature measurement, and best-corrected visual acuity. Results Data from 1215 phakic right eyes were analyzed. The prevalence of myopia (spherical equivalent (SE) o À 0.5 diopters (D)) was 20.5% (95% confidence interval (CI): 18.2 À 22.8%), of high myopia (SE o À 6.0 D) was 1.0% (95% CI: 0.4 À 1.5%), of hyperopia (SE4 þ 0.5 D) was 41.8% (95% CI: 38.9 À 44.4%), of astigmatism (cylinder o À 0.5 D) was 63.7% (95% CI: 61.0 À 66.4%), and of anisometropia (difference in SE between eyes 41.0 D) was 13.8% (95% CI: 11.9 À 15.8%). Myopia prevalence decreased with age and tended to transition into hyperopia with age up to 60 À 69 years. In subjects older than this, the trend in SE refractive errors reversed with age. The prevalence of astigmatism and anisometropia increased consistently with age. The refractive status was not significantly different between males and females. Conclusions The prevalence of myopia and hyperopia in rural adult Koreans was similar to that of rural Chinese. The prevalence of high myopia was lower in this Korean sample than in other East Asian populations, and astigmatism was the most frequently occurring refractive error.

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Section: Resultssupporting

confidence: 82%

Section: Resultsmentioning

confidence: 42%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Refractive errors in a rural Korean adult population: the Namil Study

Yoo

Kim

Park

et al. 2013

Eye

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Nonsyndromic High Myopia in a Chinese Family Mapped to MYP1

Guo¹

2010

Arch Ophthalmol

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To identify the genetic locus for X-linked nonsyndromic high myopia in a large Chinese family. Methods: Phenotypic information and DNA samples were collected from 19 individuals in a Chinese family; 7 had high myopia and 12 were unaffected. We performed a linkage scan on the X chromosome and sequenced several candidate genes. Results: High myopia in this family, presenting since early childhood and ranging from −6.00 to −15.00 diopters of sphere, is consistent with an X-linked recessive trait. The presence of a normal optic disc and the absence of color visual defects and other systemic abnormalities indicated that high myopia in this family is nonsyndromic. Our linkage analysis mapped the disease locus to Xq28, a 6.1-cM region between DXS8069 and Xqter, with 2-point logarithm of odds scores greater than 2.0 for 5 markers and a maximum logarithm of odds score of 3.59 at =0 for 2 markers. Sequence analysis of coding and adjacent intronic regions of GPR50, PRRG3, CNGA2, and BGN did not identify any potential causative mutation. Conclusions: Nonsyndromic high myopia in a Chinese family was mapped to the MYP1 region, which confirmed and refined this region for high myopia. In addition, our results suggest that color visual defects and optic disc hypoplasia are not necessary signs of high myopia attributed to the MYP1 region. Clinical Relevance: MYP1 is a common and the best locus for positional cloning of the gene responsible for high myopia. Our results suggest that MYP1 is also responsible for nonsyndromic high myopia.

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Prevalence and Characteristics of Myopic Retinopathy in a Rural Chinese Adult Population

Gao¹

2011

Arch Ophthalmol

125

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Refractive Errors in a Rural Chinese Adult PopulationThe Handan Eye Study

Cited by 173 publications

References 31 publications

Refractive errors in a rural Korean adult population: the Namil Study

Refractive errors in a rural Korean adult population: the Namil Study

Nonsyndromic High Myopia in a Chinese Family Mapped to MYP1

Prevalence and Characteristics of Myopic Retinopathy in a Rural Chinese Adult Population

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