Abstract. The physical phenomena resulting from forces exerted on a liquid-crystal mesophase on the account of the electric, magnetic, thermal fields and deformation are due to the weak intermolecular interaction of the structural elements of liquid-crystal media. In order to take an advantage of the factors, such as the presence of weak dispersion forces between the molecules of liquid crystals and the high orienting ability, the liquid-crystal anisotropic medium has been considered for visualizing, fixing, and orienting human red blood cells and DNA. The feedback mechanism of the liquid crystal self-organization has been discussed, due to the interaction with erythrocytes; moreover, the spectral features of the LC with DNA have been shown. In the present paper, the special accent will be on the orientation of these types of the bio-objects under the conditions in which the interface between solid and liquid crystal mesophase is modified via laser oriented deposition technique, as well as by using the surface electromagnetic waves treatment. It provokes the best visualization and orientation of the bio-objects in the anisotropic liquid crystal media when the direct orienting polymer coatings have been removed.