Refractory Mycoplasma pneumoniae Pneumonia in Children: Early Recognition and Management

Tong, Lihong; Huang, Shumin; Zheng, Chao; Zhang, Yuanyuan; Chen, Zhimin

doi:10.3390/jcm11102824

Cited by 57 publications

(39 citation statements)

References 152 publications

(215 reference statements)

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“…Refractory MPP (RMPP) is a condition that does not improve after seven days of standard Macrolide therapy ( 9 ). In recent years, the increasing proportion of RMPP has posed a significant challenge to paediatricians ( 10 ). A South Korean study of 5,294 children with pneumonia showed RMPP rates of more than 20% ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Zhang

Wang

et al. 2023

Front. Pediatr.

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BackgroundThe purpose of this study was to evaluate the efficacy and safety of BAL in treating MPP.MethodsFrom January 2013 to January 2019, 1,689 pediatric patients with MPP were analyzed retrospectively. Patients were subdivided into BAL group and non-BAL group according to whether they received BAL treatment within seven days after admission. The propensity score matching method matched patients' baseline characteristics (1:1). The primary outcomes were hospital stays and the cure rate. Secondary outcomes included mortality, co-infection, repeat hospitalization within 30 days, and total cost of treatment.ResultsAfter matching, 524 patients (BAL: 262; control: 262) were recorded. The BAL group had significantly shorter hospital stays (OR: 0.5, 95% CI: 0.4–0.7). Meanwhile, BAL did not significantly modify the cost, co-infection rate, and mortality. In subgroup analyses, the group with BAL intervention within three days had a significantly shorter hospital stay (OR: 0.4, 95% CI: 0.3–0.5) compared with the group with BAL intervention three days after admission.ConclusionsEarly BAL intervention is a better treatment than conventional drug therapy alone, and no significant complications were seen in this study. BAL intervention has an excellent clinical benefit. The earlier the intervention, the better the effect.

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Section: Introductionmentioning

confidence: 99%

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Zhang

Wang

et al. 2023

Front. Pediatr.

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“…The airway and lung lesions of some individuals with refractory MPP (RMPP) remain severe, even if the children's body temperature returns to normal after standard treatment. Con dent children with RMPP suffer from problems, including atelectasis and pulmonary consolidation [14]. The bronchoscope has been widely used to diagnose and treat pediatric respiratory diseases.…”

Section: Discussionmentioning

confidence: 99%

Acetylcysteine and budesonide for the treatment of refractory Mycoplasma pneumoniae pneumonia in children: a clinical observation

Wang

Liu

Chen

et al. 2023

Preprint

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Background To examine the clinical impact of bronchoscope alveolar lavage (BAL) combination with budesonide, ambroxol + budesonide, or acetylcysteine + budesonide in the treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP). Methods Eighty-two RMPP patients admitted to Pediatrics at The First People's Hospital of Zhengzhou were retrospectively evaluated between August 2016 and August 2019. All patients were administered BAL in addition to intravenous Azithromycin, expectoration, and nebulizer inhalation. The medications added to the BLA separated the patients into the Budesonide group, Ambroxol+budesonide group, and acetylcysteine+budesonide group. Analyzed were the variations in laboratory examination indices, improvement in lung imaging, overall effective rate, and adverse responses in the three groups. Results The laboratory test indices of patients in all three groups improved significantly relative to pre-treatment levels, and the results were statistically significant. After therapy, there were no significant differences between the three groups in terms of white blood cell (WBC), C-reactive protein (CRP), or erythrocyte sedimentation rate (ESR). Serum lactate dehydrogenase (LDH) and serum ferritin (SF) varied significantly across the three groups (P0.05). In the acetylcysteine + budesonide group, the absorption rate of lung imaging lesions and clinical efficacy were superior to those of the other two groups. There were no significant differences between the three groups in the occurrence of adverse events (P>0.05). Conclusions BLA-coupled acetylcysteine+ budesonide was superior to the other two groups in enhancing the effectiveness of RMPP in children, which might increase lung opacity absorption and minimize lung inflammation.

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“…Kolejnym przykładem zastosowania genomiki porów nawczej we współczesnej nauce są badania nad Mycoplasma pneumoniae. Ta beztlenowa bakteria jest jedną z najczęstszych przyczyn infekcji górnych i dolnych dróg oddechowych oraz stanów zapalnych płuc, które rozwijają się u 10-40% zakażonych pacjentów [69]. Ze względu na niezdolność bakterii do syntezy peptydoglikanu, jest naturalnie oporna na antybiotyki β-laktamowe.…”

Section: Odwrotna Wakcynologia Pangenomowaunclassified

Współczesne Metody Identyfikacji Białkowych Antygenów Szczepionkowych

Jabłuszewski

Wyszyńska

2022

Postępy Mikrobiologii - Advancements of Microbiology

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Streszczenie Postępy w genomice związane z ustawicznym sekwencjonowaniem kompletnych genomów drobnoustrojów, w tym mikroorganizmów patogennych, zrewolucjonizowały podejście do wyboru i projektowania antygenów szczepionkowych nowej generacji. Odwrócono klasyczny proces badawczy, ponieważ to zbiór danych genomowych stał się źródłem hipotez o immunogenności wytypowanych antygenów. W efekcie, możliwe jest wydajne przeanalizowanie tysięcy genów, niezależnie od poziomu ich ekspresji in vivo. Na tej podstawie typuje się pulę białkowych kandydatów, które można następnie poddać dalszym badaniom i dokładnie opisać ich epitopy powierzchniowe rozpoznawane przez elementy układu odpornościowego człowieka. Informacje o strukturze wybranego antygenu i jego interakcjach z układem immunologicznym mogą posłużyć do syntezy nowych cząsteczek, optymalizując czas i środki niezbędne do wprowadzenia do użytku nowego preparatu szczepionkowego.

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Refractory Mycoplasma pneumoniae Pneumonia in Children: Early Recognition and Management

Cited by 57 publications

References 152 publications

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Effects of bronchoalveolar lavage on Mycoplasma Pneumoniae pneumonia: A propensity score matched-cohort study

Acetylcysteine and budesonide for the treatment of refractory Mycoplasma pneumoniae pneumonia in children: a clinical observation

Współczesne Metody Identyfikacji Białkowych Antygenów Szczepionkowych

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