Refractory rhabdomyolysis responsive to corticosteroid therapy

Hammers, Marissa; Hashim, Faris; Hanna, Christian; Farris, Amanda C.; Blasick, Stephanie

doi:10.1080/08998280.2020.1851627

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Our patient used cyclophosphamide during pretreatment, which might have also been implicated in the development of the disease. The role of steroids in rhabdomyolysis development is unclear, but some investigations revealed that myopathy caused by steroids tends to be more severe and with a worse prognosis [ 19 , 29 ], whereas others supported the notion that methylprednisolone could be a salvage regimen for rhabdomyolysis [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Acute rhabdomyolysis in hepatitis-associated aplastic anemia patient undergoing allogeneic hematopoietic stem-cell transplantation: case report and literature review

Hong

Shen

et al. 2022

Eur J Med Res

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Background Hepatitis-associated aplastic anemia (HAAA) is a specific type of aplastic anemia, and hematopoietic stem-cell transplantation (HSCT) is recommended as the first-line. Acute rhabdomyolysis (AR) during hematopoietic stem-cell transplantation (HSCT) is a rare, serious complication, with only 10 cases reported in the world so far. Case presentation Herein, we present a case of AR developing during HLA-haploidentical HSCT in a 55-year-old man who suffered from HAAA. On day 7 after stem cell transfusion, the patient reported a muscle pull in thigh and complained of muscle swelling, pain and change in urine color. Despite the timely diagnosis (based on the levels of myoglobin and creatine kinase, and muscle MRI findings, etc.) and rapid hydration and alkalization, the situation progressed dramatically, and the patient died of multi-organ failure during the preparation for continuous renal replacement therapy (CRRT). Five days after his death, the whole-exome sequencing result confirmed that the patient had a germline missense mutation in SCN4A I 1545 V and ACTN3 R577X. Conclusion AR is a rare but threatening complication during HSCT, especially in cases with kidney dysfunction. The creatine kinase level may not truly and completely reflect the severity and prognosis for cases with localized lesion. We suggest that genetic analysis should be performed for better understanding the pathological changes of AR during HSCT, especially for patients with bone marrow failure.

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Section: Discussionmentioning

confidence: 99%

Acute rhabdomyolysis in hepatitis-associated aplastic anemia patient undergoing allogeneic hematopoietic stem-cell transplantation: case report and literature review

Hong

Shen

et al. 2022

Eur J Med Res

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“… 13 Alternatively, corticosteroids have been shown to be effective against rhabdomyolysis caused by various aetiologies ( Table 2 ). 6 , 7 , 14 – 20 Here, we report the first case of rhabdomyolysis in a patient undergoing dialysis treatment who was receiving telbivudine for hepatitis B virus infection.…”

Section: Introductionmentioning

confidence: 93%

Telbivudine-induced rhabdomyolysis in a patient undergoing haemodialysis: A case report and review of literature

Wu,

Xu,

Huang

et al. 2023

J Int Med Res

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Herein, we describe a case of acute rhabdomyolysis in a man in his early 50s undergoing haemodialysis and receiving the antiviral drug, telbivudine, for chronic hepatitis B virus (HBV) infection. Following diagnosis by electromyography (EMG), magnetic resonance image (MRI) scans and laboratory data (i.e., elevated serum creatinine kinase (CK) and myoglobin) telbivudine was discontinued and the patient was treated with methylprednisolone. While his CK and myoglobin levels decreased rapidly, his muscle weakness and pain improved slowly. Learning points include: patients undergoing haemodialysis and concomitantly receiving antiviral treatment for HBV, should have their serum levels of CK and myoglobin monitored regularly; treatment with corticosteroids maybe required; relief from rhabdomyolysis-induced muscle weakness and pain may be slow due to nerve fibre damage.

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Refractory rhabdomyolysis responsive to corticosteroid therapy

Cited by 2 publications

References 8 publications

Acute rhabdomyolysis in hepatitis-associated aplastic anemia patient undergoing allogeneic hematopoietic stem-cell transplantation: case report and literature review

Acute rhabdomyolysis in hepatitis-associated aplastic anemia patient undergoing allogeneic hematopoietic stem-cell transplantation: case report and literature review

Telbivudine-induced rhabdomyolysis in a patient undergoing haemodialysis: A case report and review of literature

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