Refractory Subcutaneous Sweet Syndrome Treated With Adalimumab

Agarwal, Ashwin; Barrow, Willis; Ma, Sisi; Nicholas, Matilda W.

doi:10.1001/jamadermatol.2016.0503

Cited by 36 publications

(17 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 Although up to 90% of cases are associated with heavy alcohol consumption, previous studies have not indicated that abstinence reverses the disease. 2,4,5 Interestingly, in our case, the cervical mass reduced in size after a 4-month alcohol withdrawal; this may be because our patient was in the early stages of the disease, with smaller masses. In previously reported cases, patients usually had a slow and relatively long clinical course.…”

Section: A Case Of Madelung Disease Improved By Alcohol Abstinencementioning

confidence: 54%

A case of Madelung disease improved by alcohol abstinence

Luo

Yuan

et al. 2020

Aust J Dermatology

View full text Add to dashboard Cite

Section: A Case Of Madelung Disease Improved By Alcohol Abstinencementioning

confidence: 54%

A case of Madelung disease improved by alcohol abstinence

Luo

Yuan

et al. 2020

Aust J Dermatology

View full text Add to dashboard Cite

“…Rarely, SSS may resolve spontaneously without any treatment, as reported by Chan et al [ 2 ]. Notably, Agarwal et al successfully treated a drug-refractory SSS case (failed slow steroid tapering and dapsone treatment) with adalimumab [ 16 ]. Essentially, treatment directed towards the underlying myeloid disorder or the discontinuation of the culprit drug in the case of drug-induced SSS might be the ultimate cure in a truly refractory SSS.…”

Section: Discussionmentioning

confidence: 99%

A Sweet Diagnosis for a Non-Resolving Rash

Tan¹,

Loh²,

Thakur³

et al. 2018

Cureus

View full text Add to dashboard Cite

Subcutaneous Sweet’s syndrome (SSS) is a rare variant of Sweet’s syndrome (SS), clinically characterized by erythematous plaques or nodules with a histologic pattern demonstrating a neutrophilic panniculitis (NP). We report a case of a 74-year-old woman with myelodysplastic syndrome (MDS) who presented with persistent fever, malaise, and non-resolving generalized erythematous nodules and was found to have an MDS-related SSS. SSS should be entertained and other causes of NP should be excluded prior to treating a patient with systemic corticosteroids. Early diagnosis of SSS in a patient not responding to broad-spectrum antibiotics is crucial as it helps to minimize unnecessary prolonged antibiotics exposure in this era of antimicrobial resistance. In patients with frequent relapses, a slow corticosteroid taper could be beneficial.

show abstract

“…A review about Sweet syndrome that was published in 2019 categorized corticosteroids and other agents such as potassium iodide or colchicine as the first-line treatments (20). Tumor necrosis factor α (TNF-α) antagonists and interleukin 1 (IL-1) inhibitors have also been reported to be effective (21)(22)(23)(24)(25)(26)(27). However, the data supporting the effectiveness of these biological agents are from case reports and small studies.…”

Section: Aml* Comparison Of Hemoglobin and Platelet Levels Between Smentioning

confidence: 99%