2019
DOI: 10.1016/j.ijpddr.2019.05.001
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Refugia and anthelmintic resistance: Concepts and challenges

Abstract: Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in ‘refugia’, unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions n… Show more

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Cited by 90 publications
(54 citation statements)
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“…The genes that underlie resistance can be used to inform parasitic nematode control practices by monitoring the spread of resistance alleles in parasite populations. The alleles present in a population can predict drug efficacy and enable the maintenance of sensitive refugia populations ( Muchiut et al, 2018 ; Hodgkinson et al, 2019 ). For BZ compounds, the first resistance gene, encoding a beta-tubulin, was identified in studies of the fungus Aspergillus nidulans ( Hastie and Georgopoulos, 1971 ; Sheir-Neiss et al, 1978 ).…”
Section: Introductionmentioning
confidence: 99%
“…The genes that underlie resistance can be used to inform parasitic nematode control practices by monitoring the spread of resistance alleles in parasite populations. The alleles present in a population can predict drug efficacy and enable the maintenance of sensitive refugia populations ( Muchiut et al, 2018 ; Hodgkinson et al, 2019 ). For BZ compounds, the first resistance gene, encoding a beta-tubulin, was identified in studies of the fungus Aspergillus nidulans ( Hastie and Georgopoulos, 1971 ; Sheir-Neiss et al, 1978 ).…”
Section: Introductionmentioning
confidence: 99%
“…The alleles present in a population can predict drug efficacy and enable the maintenance of sensitive refugia populations (Hodgkinson et al, 2019;Muchiut et al, 2018). For BZ compounds, the first resistance gene, encoding a beta-tubulin, was identified in studies of the fungus Aspergillus nidulans (Hastie and Georgopoulos, 1971;Sheir-Neiss et al, 1978).…”
Section: Introductionmentioning
confidence: 99%
“…Strategies to increase refugia such as evaluating the need to treat older animals and grazing management, including avoiding moving stock to lowly contaminated pasture after treatment, should also be adopted. Indicators such as FEC or weight gain should be utilised to help target anthelmintic treatments [52]. In addition, further research on novel strategies for managing AR GIN or slowing the further development of AR, such as combination therapy or targeted selective treatment, is required.…”
Section: Discussionmentioning
confidence: 99%