Regadenoson-induced coronary vasospasm resulting in severe reversible perfusion defects and transient ischemic dilation on SPECT stress myocardial perfusion imaging

Inferior Myocardial Infarction Secondary to Coronary Artery Vasospasm Following Regadenoson Stress Imaging

“…CAV is a rare condition that is caused by reversible subtotal or total occlusion of a coronary artery branch [ 1 ]. Physiologically, CAV is the result of local coronary smooth muscle hyperactivity leading to coronary artery occlusion [ 7 ]. Prompt diagnosis of CAV is crucial to prevent many serious life-threatening conditions such as myocardial infarction and fatal arrhythmias [ 2 ].…”

Selective Adenosine A2A Agonists May Change Myocardial Perfusion Imaging

“…Pharmacokinetics of regadenoson are triphasic, with coronary blood flow increasing to more than twice baseline at 30 seconds post-dose and decreasing to less than twice baseline at 10 minutes (10). The most common protocol for injection of regadenoson is injected as a bolus and radiotracer Ann Nucl Cardiol 2021；7(1) ：63-66 -64 -Takehana Adenosine A2A Agonist for Stress Imaging It has been reported that unpredictable side effects of regadenoson include coronary spasm, cardiac arrest, bradycardia, hypotension, and epileptic seizures (5,(13)(14)(15). These side effects are not thought to involve the above receptors.…”