Regarding associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults

Qin, Chuanjiang; Yu, Canqing; Li, Liming

doi:10.1136/heartjnl-2018-313781

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…People with the highest egg intake consumed, on average, only 0.76 egg per day 10. This is lower than the highest levels of intake in other Asian or Western countries 66. When we consider these low levels of intake, it is possible that the association was mainly driven by the egg consumption pattern rather than by egg consumption per se.…”

Section: Discussionmentioning

confidence: 90%

Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

Drouin‐Chartier

Chen

et al. 2020

BMJ

113

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Objective To evaluate the association between egg intake and cardiovascular disease risk among women and men in the United States, and to conduct a meta-analysis of prospective cohort studies. Design Prospective cohort study, and a systematic review and meta-analysis of prospective cohort studies. Setting Nurses’ Health Study (NHS, 1980-2012), NHS II (1991-2013), Health Professionals’ Follow-Up Study (HPFS, 1986-2012). Participants Cohort analyses included 83 349 women from NHS, 90 214 women from NHS II, and 42 055 men from HPFS who were free of cardiovascular disease, type 2 diabetes, and cancer at baseline. Main outcome measures Incident cardiovascular disease, which included non-fatal myocardial infarction, fatal coronary heart disease, and stroke. Results Over up to 32 years of follow-up (>5.54 million person years), 14 806 participants with incident cardiovascular disease were identified in the three cohorts. Participants with a higher egg intake had a higher body mass index, were less likely to be treated with statins, and consumed more red meats. Most people consumed between one and less than five eggs per week. In the pooled multivariable analysis, consumption of at least one egg per day was not associated with incident cardiovascular disease risk after adjustment for updated lifestyle and dietary factors associated with egg intake (hazard ratio for at least one egg per day v less than one egg per month 0.93, 95% confidence interval 0.82 to 1.05). In the updated meta-analysis of prospective cohort studies (33 risk estimates, 1 720 108 participants, 139 195 cardiovascular disease events), an increase of one egg per day was not associated with cardiovascular disease risk (pooled relative risk 0.98, 95% confidence interval 0.93 to 1.03, I 2 =62.3%). Results were similar for coronary heart disease (21 risk estimates, 1 411 261 participants, 59 713 coronary heart disease events; 0.96, 0.91 to 1.03, I 2 =38.2%), and stroke (22 risk estimates, 1 059 315 participants, 53 617 stroke events; 0.99, 0.91 to 1.07, I 2 =71.5%). In analyses stratified by geographical location (P for interaction=0.07), no association was found between egg consumption and cardiovascular disease risk among US cohorts (1.01, 0.96 to 1.06, I 2 =30.8%) or European cohorts (1.05, 0.92 to 1.19, I 2 =64.7%), but an inverse association was seen in Asian cohorts (0.92, 0.85 to 0.99, I 2 =44.8%). Conclusions Results from the three cohorts and from the updated meta-analysis show that moderate egg consumption (up to one egg per day) is not associated with cardiovascular disease risk overall, and is associated with potentially lower cardiovascular disease risk in Asian populations. Systematic review registration PROSPERO CRD42019129650.

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Section: Discussionmentioning

confidence: 90%

Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

Drouin‐Chartier

Chen

et al. 2020

BMJ

113

View full text Add to dashboard Cite

show abstract

“…We further excluded those with nutrition-related disease, including diabetes, stroke or hypertension ( n = 1908). We made these exclusion to minimize the prevalence-incidence bias and the effect of reverse causality led by potential confounders such as lifestyle factors [ 12 ]. We further excluded subjects with missing information of physical examination, left food frequency questionnaire total blank or missing main food intake and individuals with energy intake < 500 or > 5000 kcal/day ( n = 514).…”

Section: Methodsmentioning

confidence: 99%

Association of dietary cholesterol and dyslipidemia in Chinese health examinees

Pan

Han

Jiang

et al. 2022

J Health Popul Nutr

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Background The association between dietary cholesterol consumption and dyslipidemia is still in controversy. The study aims to evaluate whether dietary cholesterol intake associated with dyslipidemia and its components in Chinese health examinees. Methods A large-scale cross-sectional study was conducted among health examinees of in Shaanxi province. Totally of 8358 participants (3677 male and 4681 female) were included. Dietary cholesterol intake was assessed by validated food frequency questionnaire. Multivariable regression and restricted cubic spline models were used to capture the linear and non-linear association between dietary cholesterol and dyslipidemia. Results A total of 2429 (29.1%) subjects were newly diagnosed of dyslipidemia, the prevalence was 29.2% in male and 27.7% in female. Mean intake of dietary cholesterol was 213.7 mg/day. After adjusting for all potential confounders including demographics information and lifestyles, higher cholesterol consumption was related to lower risk of dyslipidemia, the ORs (95% CIs) across Q2 to Q4 group were 0.87 (0.60–1.26), 0.80 (0.55–1.18) and 0.61 (0.41–0.91) in female. With further controlling for nutrients principal components, a null association was observed between dietary cholesterol and dyslipidemia and serum lipids, regardless of gender. Results of restricted cubic splines showed that the risk of dyslipidemia decreased slowly until around 300 mg/day in men and 200 mg/day in women, although the non-linear association was not significant. Conclusions The study suggested that dietary cholesterol consumption was not associated with dyslipidemia or serum lipids in Chinese health examinees, although a decreased risk was observed before the threshold points.

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“…The involvement of miRNAs has been well established in various infectious diseases, including bacterial sepsis, chronic refractory respiratory disease, hepatic diseases and Plasmodium malaria infection [28][29][30]. Accumulating evidence indicates that numerous miRNAs regulate the complex interaction between survival strategies of bacteria and host innate immune pathways [31,32]. In addition to this evidence, miRNAs seem to be recognized as clinically valuable biomarkers at the early stage of diseases or for specific kinds of diseases [33].…”

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confidence: 99%

MicroRNAs miR-4535 and miR-1915-5p in Amniotic Fluid As Predictive Biomarkers for Chorioamnionitis

et al. 2021

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Background: This study was performed to investigate the clinical significance of miR-4535 and miR-1915-5p in severe chorioamnionitis. Materials & methods: Amniotic fluid samples from 37 patients with severe chorioamnionitis were subjected to miRNA array analysis and ddPCR™. Diagnostic values were assessed using the receiver operating characteristic curve. The patients were separated into three groups according to Blanc’s criteria. Results: The expression of miR-4535 and miR-1915-5p was significantly correlated with the copy number of 16S rDNA, had extremely high diagnostic accuracy for severe chorioamnionitis, and was linked to maternal and fetal inflammation. Conclusion: miR-4535 and miR-1915-5p serve as promising biomarkers for the diagnosis of severe chorioamnionitis.

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Regarding associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults

Cited by 6 publications

References 12 publications

Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

Egg consumption and risk of cardiovascular disease: three large prospective US cohort studies, systematic review, and updated meta-analysis

Association of dietary cholesterol and dyslipidemia in Chinese health examinees

MicroRNAs miR-4535 and miR-1915-5p in Amniotic Fluid As Predictive Biomarkers for Chorioamnionitis

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