Regarding “Cryopreserved venous allograft is an acceptable conduit in patients with current or prior angioaccess graft infection”

Sadaghianloo, Nirvana; Albano, Laetitia; Pourtein, Monique

doi:10.1016/j.jvs.2017.08.100

Cited by 3 publications

(2 citation statements)

References 5 publications

(10 reference statements)

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“…4,34,35 But, the patient may develop specific antibodies, which may impact the future organ transplantation. 36–38…”

Section: Discussionmentioning

confidence: 99%

“…4,34,35 But, the patient may develop specific antibodies, which may impact the future organ transplantation. [36][37][38] Given the limitations of cryopreservation for vascular grafts, other techniques have been explored in animal models. Fahner et al demonstrated that preservation of arterial allografts with glycerol is a feasible method in a large animal model with decreased intimal hyperplasia and renewed contraction and relaxation capability of the vessel wall in comparison with UW solution.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of a method for long-term preservation of the vascular allograft

Musk

et al. 2021

Vascular

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Background/objective During multiple organ procurement, blood vessels are routinely retrieved and stored in University of Wisconsin solution and then discarded after two weeks, if not used at organ transplantation owing to lack of a method for long-term preservation. Therefore, the aim of this study is to investigate a method for long-term preservation of vascular allografts in ethanol. Methods Aorta and vena cava allografts were retrieved and stored in 75% ethanol solution for 12 months at 4°C. Four pigs were divided into two groups. A segment of aorta was excised and replaced by insertion of preserved aorta graft (Group A) or vena cava graft (Group V). The pigs were observed for six weeks. A laparotomy was performed and the vascular graft was harvested for histopathology followed by euthanasia at the end of study. Results Three pigs recovered uneventfully, while one pig died from venous graft rupture in the third week after surgery. There was no aneurysmal formation or thrombosis in the grafts. Some calcification was seen over aorta allograft. On histopathology, the elastic pattern was almost normal, although the endothelial cells degenerated after preservation. After implantation, the formation of the endothelium cell-like layer was seen in both aorta and vena cava allografts. Conclusion Vascular allografts were functional after preservation for 12 months. The vena cava grafts had much less wall calcification than the aorta grafts. Further studies are necessary to investigate vascular graft remodelling with a longer observation period after implantation.

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“…4,34,35 But, the patient may develop specific antibodies, which may impact the future organ transplantation. 36–38…”

Section: Discussionmentioning

confidence: 99%