Regeneration after physeal distraction of the radius in sheep

Peltonen, J.; Kahri, Arvi; Karaharju, Erkki; Alitalo, I.

doi:10.3109/17453678809149423

Cited by 12 publications

(4 citation statements)

References 12 publications

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“…The perpendicular orientation of the woven bone suggests a mechanical influence (strain) within the gap (26,32,45,46) . With distraction osteogenesis, as tension forces are applied to the gap tissue, the collagen template becomes oriented in the direction of the applied tension, and woven bone formation follows this collagen scaffold (5,7,47) . We could not conclude whether there was direct mineralization of the fibrous gap tissue (10) or that the bone formed only around a pre‐existing collagen template (48) ; however, it is likely that both methods occur concurrently.…”

Section: Discussionmentioning

confidence: 99%

Histomorphometry of Distraction Osteogenesis in a Caprine Tibial Lengthening Model

Welch

Birch

Makarov

et al. 1998

Journal of Bone and Mineral Research

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Section: Discussionmentioning

confidence: 99%

Histomorphometry of Distraction Osteogenesis in a Caprine Tibial Lengthening Model

Welch

Birch

Makarov

et al. 1998

Journal of Bone and Mineral Research

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“…While many of the technical difficulties have been addressed [8–10], the precise mechanism through which the formation of new bone occurs during callotasis is still debated [11–17], and a lack of consistency in the published literature remains on the histological findings at the site of formation of new bone [18–21]. Both endosteal and periosteal bone formation have been proposed to occur during distraction [22–25]. Endochondral ossification from the central fibrous tissue has been shown in the distraction gap in experimental models of distraction osteogenesis in rabbits [24, 26].…”

Section: Introductionmentioning

confidence: 99%

Bone lengthening osteogenesis, a combination of intramembranous and endochondral ossification: an experimental study in sheep

Forriol¹,

Denaro

Longo

et al. 2010

Strategies in Trauma and Limb Reconstruction

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We evaluated the morphological features of the newly formed tissue in an experimental model of tibial callotasis lengthening on 24 lambs, aged from 2 to 3 months at the time of operation. A unilateral external fixator prototype Monotube Triax® (Stryker Howmedica Osteonics, New Jersey) was applied to the left tibia. A percutaneous osteotomy was performed in a minimally traumatic manner using a chisel. Lengthening was started 7 days after surgery and was continued to 30 mm. The 24 animals were randomly divided into three groups of 8 animals each: in Group 1, lengthening took place at a rate of 1 mm/day for 30 days; in Group 2, at a rate of 2 mm/day for 15 days; in Group 3, at a rate of 3 mm/day for 10 days. In each group, 4 animals were killed 2 weeks after end of lengthening, and the other 4 animals at 4 weeks after end of lengthening. To assess bony formation in the distraction area, radiographs were taken every 2 weeks from the day of surgery. To study the process of vascularization, we used Spalteholz’s technique. After killing, the tibia of each animal was harvested, and sections were stained with hematoxylin and eosin, Masson’s trichrome, and Safranin-O. Immunohistochemistry was performed, using specific antibodies to detect collagens I and II, S100 protein, and fibronectin. A combination of intramembranous and endochondral ossification occurred together at the site of distraction. Our study provides a detailed structural characterization of the newly formed tissue in an experimental model of tibial lengthening in sheep and may be useful for further investigations on callotasis.

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“…Increase of total body height of 15 to 24 cm has been reported during 10 to 15 cm of lengthening [33]. Experimental work is contradictory; some authors show disturbances of growth [29,39,53], whereas others found no effect [2,12,15,22,43,44,50]. Rupture of the proliferative zone initiates premature closure, but rupture of hypertrophic cell zone does not influence growth [38,51,51].…”

mentioning

confidence: 99%

Comparison of distraction epiphyseolysis and partial metaphyseal corticotomy in leg lengthening

Franke

Hein

Simon

et al. 1990

International Orthopaedics

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We have used Ilazorov's method of distraction epiphyseolysis for leg lengthening since 1977 and his new method of corticotomy or compactotomy since 1983. The first method was carried out in 22 lower limbs with an average lengthening of 8.25 cm (range 4 to 18 cm); included in this group are 2 patients with achondroplasia in whom both legs were lengthened 12 cm. In the second method, a corticotomy is carried out at the metaphyseal-diaphyseal junction followed by distraction in Ilazorov's apparatus (4 x 0.25 mm a day). We lengthened 30 legs; included are 5 patients who had both legs lengthened from between 8 and 12 cm. In the remainder an average of 7.9 cm of lengthening was achieved (range from 4 to 15 cm). The index for the treatment time per cm achieved (time from operation until full weight-bearing per cm of lengthening) was shorter after distraction epiphyseolysis than after corticotomy. Complications were also a little less after the latter procedure. Distraction epiphyseolysis has to be limited to children from aged 12 years until growth ceases. The advantage with corticotomy is that it can be done at any age from 5 to 30 years. Care is needed in both cases to avoid complications.

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Regeneration after physeal distraction of the radius in sheep

Cited by 12 publications

References 12 publications

Histomorphometry of Distraction Osteogenesis in a Caprine Tibial Lengthening Model

Histomorphometry of Distraction Osteogenesis in a Caprine Tibial Lengthening Model

Bone lengthening osteogenesis, a combination of intramembranous and endochondral ossification: an experimental study in sheep

Comparison of distraction epiphyseolysis and partial metaphyseal corticotomy in leg lengthening

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