Regeneration of Axons after Nerve Transection Repair Is Enhanced by Degradation of Chondroitin Sulfate Proteoglycan

Zuo, Jian; Neubauer, Debbie; Graham, James B.; Krekoski, Craig A.; Ferguson, Toby A.; Muir, David

doi:10.1006/exnr.2002.7922

Cited by 141 publications

(94 citation statements)

References 24 publications

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“…As a group they are known to inhibit neurite outgrowth and axonal regeneration and promote neural cell death [5][6][7][8][9]. However enzymic removal of chondroitin sulphate promotes axonal regeneration [10]. Maintenance of the appropriate quantity and location of CNS CSPGs is thus likely to be of major importance to the correct functioning of the brain and may also influence the balance between neuronal death and survival.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis

Cross

Haddock

Surr

et al. 2006

Journal of Autoimmunity

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Section: Introductionmentioning

confidence: 99%

Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis

Cross

Haddock

Surr

et al. 2006

Journal of Autoimmunity

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“…This treatment option has been shown to lead to marked enhancement of peripheral nerve regeneration through acellular nerve grafts. 63 Additionally, chondroitinase treatment has shown to improve nerve regeneration in both a rat model of nerve transection and crush injury. 64 Chondroitinase has been shown to improve nerve regeneration in a rat orthotopic hind limb transplant model, with animals receiving the enzyme demonstrating statistically greater total number of fibers and nerve density compared with controls.…”

Section: Growth Hormonementioning

confidence: 99%

Advances in peripheral nerve regeneration as it relates to VCA

Suchyta

Sabbagh

Morsy

et al. 2016

Vascularized Composite Allotransplantation

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Vascularized composite allotransplant (VCA) offers functional, social, and quality of life improvements for patients who have exhausted traditional reconstructive options. Unlike solid organ transplant, VCA success is not only based upon the quality of perfusion and level of immunosuppression, but also on the success of nerve regeneration within the transplanted part. This paper will summarize the present state of peripheral nerve regeneration in the context of VCA and will explore the latest research advances that will affect the future of the field. These advances offer promising future strategies to improve patient outcomes in VCA.

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“…However, MAG and CSPGs also exist in lesioned peripheral nerves, yet do not interfere with axon growth in that setting Please address correspondence to: Ying Jin, Ph.D., Department of Physiology, University of Kentucky, Lexington,KY 40536,Tel: (859) Fax: (859) 257-5737, E-mail: yjin2@email.uky.edu. (Chen et al, 2002;Fawcett and Asher, 1999;McKerracher et al, 1994;Zuo et al, 2002). This difference indicates that axon regeneration depends not on the presence or absence of single molecules, but on the complex interplay of growth-supportive and growth-inhibitory signals within the environment.…”

Section: Introductionmentioning

confidence: 99%

Axon growth across a lesion site along a preformed guidance pathway in the brain

Jin¹,

Ziemba²,

Smith³

2008

Experimental Neurology

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Our previous studies showed that axonal outgrowth from dorsal root ganglia (DRG) transplants in the adult rat brain could be directed toward a specific target location using a preformed growthsupportive pathway. This pathway induced axon growth within the corpus callosum across the midline to the opposite hemisphere. In this study, we examined whether such pathways would also support axon growth either through or around a lesion of the corpus callosum. Pathways expressing GFP, NGF, or FGF2/NGF were set up by multiple injections of adenovirus along the corpus callosum. Each pathway included the transplantation site in the left corpus callosum, 2.8 mm away from the midline, and a target site in the right corpus callosum, 2.5 mm from the midline. At the same time, a 1 mm lesion was made through the corpus callosum at the midline in an anteroposterior direction. A group of control animals received lesions and Ad-NGF injections only at the transplant and target sites, without a bridging pathway. DRG cell suspensions from postnatal day 1 or 2 rats were injected at the transplantation site three to four days later. Two weeks after transplantation, brain sections were stained using an anti-CGRP antibody. The CGRP-positive axons were counted at 0.5 mm and 1.5 mm from the lesion site in both hemispheres. Few axons grew past the lesion in animals with control pathways, but there was robust axon growth across the lesion site in the FGF2/NGF and NGFexpressing pathways. This study indicated that preformed NGF and combination guidance pathways support more axon growth past a lesion in the adult mammalian brain.

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Regeneration of Axons after Nerve Transection Repair Is Enhanced by Degradation of Chondroitin Sulfate Proteoglycan

Cited by 141 publications

References 24 publications

Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis

Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis

Advances in peripheral nerve regeneration as it relates to VCA

Axon growth across a lesion site along a preformed guidance pathway in the brain

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