Regeneration of Blood Vessels

Wang, Kai; Cui, Wei-Long; Wei, Yongzhen; Zhu, Meifeng; Zhao, Qiang

doi:10.1007/978-981-10-2293-7_11

Cited by 3 publications

(3 citation statements)

References 145 publications

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“…Similarly, the implantation site should allow long graft lengths, so the effects of transmural endothelialization can be isolated from other mechanisms. Also, it should exhibit similar immunogenicity and thrombogenicity mechanisms as humans (Wang et al, ). Commonly used animal models are baboons, sheep, dogs, pigs, rabbits, and rats (Byrom et al, ).…”

Section: Animal Models and Endothelializationmentioning

confidence: 99%

“…It has been seen that the animal model choice can have a specific effect on the endothelialization and that results obtained from animal trials cannot always be extrapolated to a human context (see Table 2). (Wang et al, 2016). Commonly used animal models are baboons, sheep, dogs, pigs, rabbits, and rats (Byrom et al, 2010).…”

Section: Animal Models and Endothelializationmentioning

confidence: 99%

“…This is primarily due to the fact that such in vitro techniques are currently unable to reproduce the complexity of the full endothelialization process, which takes place once the graft is implanted. Consequently, one of the most crucial decisions during TEVG development is the animal model selection (Wang et al, ).…”

Section: Animal Models and Endothelializationmentioning

confidence: 99%

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Endothelialization mechanisms in vascular grafts

Sánchez

Brey

Briceño

2018

J Tissue Eng Regen Med

108

101

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Despite the wide variety of tissue-engineered vascular grafts that are currently being developed, autologous vessels, such as the saphenous vein, are still the gold standard grafts for surgical treatment of vascular disease. Recently developed technologies have shown promising results in preclinical studies, but they still do not overcome the issues that native vessels present, and only a few have made the transition into clinical use. The endothelial lining is a key aspect for the success or failure of the grafts, especially on smaller diameter grafts (<5 mm). However, during the design and evaluation of the grafts, the mechanisms for the formation of this layer are not commonly examined. Therefore, a significant amount of established research might not be relevant to the clinical context, due to important differences that exist between the vascular regeneration mechanisms found in animal models and humans. This article reviews current knowledge about endothelialization mechanisms that have been so far identified: in vitro seeding, transanastomotic growth, transmural infiltration, and fallout endothelialization. Emphasis is placed on the models used for study of theses mechanisms and their effects on the development of tissue-engineering vascular conduits.

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Section: Animal Models and Endothelializationmentioning

confidence: 99%

Section: Animal Models and Endothelializationmentioning

confidence: 99%

See 1 more Smart Citation

Endothelialization mechanisms in vascular grafts

Sánchez

Brey

Briceño

2018

J Tissue Eng Regen Med

108

101

View full text Add to dashboard Cite

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Biomaterial‐Induction of a Transplantable Angiosome

Charbonnier

Maillard

Sayed

et al. 2019

Adv Funct Materials

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Creating transplantable vascular networks (angiosomes) that are fed and drained by vessels large enough to be surgically reconnected is key to harnessing the potential of regenerative medicine and advancing reconstructive surgical techniques. Currently, the only way to create a new angiosome is nontrivial and involves pressurizing a vein graft by its surgical attachment to an artery forming an arteriovenous loop (AVL). Material induction of a venous angiosome is reported, by placement of a 3D printed microporous monetite scaffold around a vein and its transplantability is further demonstrated. When the transplanted venosome is cut, it bleeds, illustrating potential reconstructive functionality. The volume of blood vessels generated by biomaterial-induction is as great as by AVL. Direct contact of the material with the vein does not appear to be critical to luminal sprouting, and wrapping the implant in a silicone membrane significantly reduces sprouting. Pilot studies with microporous polymeric scaffolds induce far less vascular invasion. After 4 weeks, monetite scaffolds are extensively vascularized and can be transplanted to an arterial vessel. This report is significant since a lack of tools to control vascular generation is an impediment to the treatment of several conditions that give rise to tissue ischemia and tissue reconstruction.

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Bioinorganic Angiogenesis

Maillard

Charbonnier

Sayed

et al. 2018

Preprint

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Causing a large diameter blood vessel to sprout branches and a capillary network on demand to create a new angiosome is key to harnessing to potential of regenerative medicine and advancing reconstructive surgery. Currently this can only be achieved by connecting a vein graft to an artery by microsurgery, the arteriovenous loop technique (AVL). The arterial blood pressure in the thin-walled vein is thought to drive remodelling to create branches, however the surgical complexity limits the application of the technique. In this study we demonstrate that unexpectedly, a vessel density of luminal branches in excess of that achieved by the surgical AVL approach can be induced simply by placing a vein in contact with a microporous calcium phosphate. Only osteoinductive biomaterials have been reported previously, this is thought to be the first report of an angio-inductive material. Pilot studies indicated that the material type greatly affected the degree of luminal vascularization.Material contact with the vein is not a requirement for luminal angiogenesis of the vein and together these findings point to a bioinorganic effect, wherein the degradation of the material both releases a stimulatory ionic milieu and creates space for the developing angiosome.

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Regeneration of Blood Vessels

Cited by 3 publications

References 145 publications

Endothelialization mechanisms in vascular grafts

Endothelialization mechanisms in vascular grafts

Biomaterial‐Induction of a Transplantable Angiosome

Bioinorganic Angiogenesis

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