2011
DOI: 10.1089/ten.tea.2011.0122
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Regeneration of Completely Transected Spinal Cord Using Scaffold of Poly(D,L-Lactide-co-Glycolide)/Small Intestinal Submucosa Seeded with Rat Bone Marrow Stem Cells

Abstract: Using a complete spinal cord transection model, the present study employed a combinatorial strategy comprising rat bone marrow stem cells (rBMSCs) and polymer scaffolds to regenerate neurological function after spinal cord injury (SCI) of different lengths. SCI models with completely transected lesions were prepared by surgical removal of 1 mm (SC1) or 3 mm (SC3) lengths of spinal cord in the eighth-to-ninth spinal vertebrae, a procedure that resulted in bilateral hindlimb paralysis. A cylindrical poly(D,L-lac… Show more

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Cited by 45 publications
(28 citation statements)
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“…MSCs have been demonstrated to promote axonal regeneration and suppress demyelination [100] . Several different studies in rat models found that MSCs induce nerve regeneration, modulate the production of inflammatory cytokines such as TNF-α and IL-6 and reduce myeloperoxidase activity [101][102][103][104][105] . Menezes et al [106] hypothesized that laminin may play a pivotal role in neuron and axon preservation and regeneration after finding deposits of the glycoprotein on the lesion site …”
Section: Resultsmentioning
confidence: 99%
“…MSCs have been demonstrated to promote axonal regeneration and suppress demyelination [100] . Several different studies in rat models found that MSCs induce nerve regeneration, modulate the production of inflammatory cytokines such as TNF-α and IL-6 and reduce myeloperoxidase activity [101][102][103][104][105] . Menezes et al [106] hypothesized that laminin may play a pivotal role in neuron and axon preservation and regeneration after finding deposits of the glycoprotein on the lesion site …”
Section: Resultsmentioning
confidence: 99%
“…Based on these results, it was suggested that repetitive IT transplantation, which imposes a minimal burden on the animals, may improve behavioral function when the dose, timing, and targeted IT delivery of MSCs towards the lesion cavity was optimized. Kang et al [51] , indicated that therapeutic rat BMSCs in a poly (D,L-lactide-co-glycolide)/small intestinal submucosa scaffold induced nerve regeneration in a complete spinal cord transection model and demonstrated that functional recovery further depended on defect length.…”
Section: Bone Marrow Stromal Cellsmentioning
confidence: 99%
“…Rat Axonal regeneration, functional recovery Feasibility of therapeutic cell delivery using 3D scaffolds, especially in complete spinal cord transection Kang et al [51] , 2011…”
Section: Ratmentioning
confidence: 99%
“…132,135 In addition to these native ECM molecules, the collagen fiber orientation that is maintained after the decell process has also attracted attention. 132 Both of these inherent properties have sparked strategies employing SIS as scaffolds in the fields of cardiovascular, [137][138][139][140] bone, [141][142][143] nerve, 144 soft tissue, 86,87,145 and urogenital [146][147][148][149] tissue engineering (Table 6). Currently, SIS is Food and Drug Administration (FDA) approved for several urogenital applications, including hernia repair.…”
Section: Small Intestinal Submucosamentioning
confidence: 99%