Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

Jackson, Kathyjo A.; Majka, Susan M.; Wang, Hongyu; Pocius, Jennifer; Hartley, Craig J.; Majesky, Mark W.; Entman, Mark L.; Michael, Lloyd H.; Hirschi, Karen K.; Goodell, Margaret A.

doi:10.1172/jci12150

Cited by 1,765 publications

(1,159 citation statements)

References 32 publications

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“…The so-called hematopoietic stem cell (HSC) is an early derivative of the ES cell type and expresses a spectrum of markers that is characteristic of the phenotype of the stem cell (i.e., c-Kit, Sca-1, and CD34) (Bacigalupo et al, 2002;Jackson et al, 2001). After their migration from the para-aortic/aorta-gonad-mesonephros region, the HSCs populate various organs before settling into the bone marrow (reviewed in Dieterlen-Lievre et al, 2002).…”

Section: Stem Cells In the Embryomentioning

confidence: 99%

“…Recent studies indicate a significant contribution of stem cells, likely of bone marrow origin, to the homeostasis and/or repair of the adult heart (Jackson et al, 2001;Orlic et al, 2001;Hughes, 2002;Laflamme et al, 2002;Quaini et al, 2002). In addition, the existence of a socalled myocardial stem cell population has been suggested (Hierlihy et al, 2002), but it is not clear how this population contributes to the respective established cardiac cell types in the heart, nor has the origin/phenotype of these cells been properly described.…”

Section: Contributions Of Stem Cells To the Adult Heartmentioning

confidence: 99%

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The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

2003

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After its initial formation the epicardium forms the outermost cell layer of the heart. As a result of an epithelial-to-mesenchymal transformation (EMT) individual cells delaminate from this primitive epicardial epithelium and migrate into the subepicardial space (Pérez-Pomares et al., Dev Dyn 1997; 210: 96 -105; Histochem J 1998a;30:627-634 Dev. Biol. 2002b;247:307-326). A subset of EPDCs continue to differentiate in a variety of different cell types (including coronary endothelium, coronary smooth muscle cells (CoSMCs), interstitial fibroblasts, and atrioventricular cushion mesenchymal cells), whereas other EPDCs remain in a more or less undifferentiated state. Based on its specific characteristics, we consider the EPDC as the ultimate 'cardiac stem cell'. In this review we briefly summarize what is known about events that relate to EPDC development and differentiation while at the same time identifying some of the directions where EPDCrelated research might lead us in the near future. Anat Rec Part A 276A: 43-57, 2004.

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Section: Stem Cells In the Embryomentioning

confidence: 99%

Section: Contributions Of Stem Cells To the Adult Heartmentioning

confidence: 99%

The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

2003

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“…Several investigators in the past few years have demonstrated that BM-derived cells can contribute to the regeneration of nonhematopoietic organs and tissues (Jackson et al, 2001;Orlic et al, 2001;Corbel et al, 2003;Kale et al, 2003). These observations were mainly explained by the hypothesis that HSC are "plastic" and, thus, could trans-dedifferentiate into stem cells committed for various organs and tissues (Mezey et al, 2000;Corti et al, 2002b).…”

Section: Bm-derived Stem Cells and Tissue/organ Regeneration: Evidencmentioning

confidence: 99%

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

Kucia

Wan

Ratajczak

2007

Developmental Dynamics

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Data from our and other laboratories provide evidence that bone marrow (BM) contains a population of stem cells that expresses early developmental markers such as (1) stage-specific embryonic antigen (SSEA) and (2) transcription factors Oct-4 and Nanog. These are the markers characteristic for embryonic stem cells, epiblast stem cells, and primordial germ cells (PGC). The presence of these stem cells in adult BM supports the concept that this organ contains some population of pluripotent stem cells that is deposited in embryogenesis during early gastrulation. We hypothesize that these cells could be direct descendants of the germ lineage that, to pass genes on to the next generations, has to create soma and, thus, becomes a "mother lineage" for all somatic cell lineages present in the adult body. Germ potential is established after conception in totipotent zygotes and retained in blastomeres of morula, cells from the inner cell mass of blastocyst, epiblast, and population of PGC. We will present a concept that SSEA ؉ Oct-4 ؉ Nanog ؉ cells identified in BM could be descendants of epiblast cells as well as some rare migrating astray PGC. Developmental Dynamics 236:3309 -3320, 2007.

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“…An additional observation from research on adult stem cells that may shed light on the formation of the myocardium in the embryo is that noncardiac stem cells can differentiate into cardiomyocytes if introduced into the adult heart (Jackson et al, 2001;Malouf et al, 2001;Orlic et al, 2001;Anversa and Nadal-Ginard, 2002). That is to say, what provoked these noncardiac stem cells to become cardiomyocytes is their association with the myocardial environment.…”

Section: Stem Cell Plasticity-implications For Heart Formation In Thementioning

confidence: 99%

Stem cells and the formation of the myocardium in the vertebrate embryo

2003

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A major goal in cardiovascular biology is to repair diseased or damaged hearts with newly generated myocardial tissue. Stem cells offer a potential source of replacement myocytes for restoring cardiac function. Yet little is known about the nature of the cells that are able to generate myocardium and the conditions they require to form heart tissue. A source of information that may be pertinent to addressing these issues is the study of how the myocardium arises from progenitor cells in the early vertebrate embryo. Accordingly, this review will examine the initial events of cardiac developmental biology for insights into the identity and characteristics of the stem cells that can be used to generate myocardial tissue for therapeutic purposes. Anat Rec Part A 276A:2-12, 2004.

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Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

Cited by 1,765 publications

References 32 publications

The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells

Bone marrow‐derived very small embryonic‐like stem cells: Their developmental origin and biological significance

Stem cells and the formation of the myocardium in the vertebrate embryo

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