Regeneration of Maxillary Sinus Mucosa following Surgical Removal

Forsgren, Karin; Stierna, Pontus; Kumlien, J; Carlsöö, Bengt

doi:10.1177/000348949310200610

Cited by 80 publications

(86 citation statements)

References 19 publications

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“…Although thioridazine has the potential to induce motoric effects in humans, its propensity to induce acute dystonias is much lower compared to the classical neuroleptics such as haloperidol. Additionally, it also appears to have a lower potency to induce catalepsy in rodents compared to other neuroleptics (28). Thus, a correlation appears to exist between the propensity of the antipsychotic drugs to cause certain acute EPS in humans (or catalepsy in rodents) and their ability to induce NT/N mRNA expression in the DLSt ofthe rat.…”

Section: Resultsmentioning

confidence: 98%

“…dose of haloperidol (1 mg/kg), fluphenazine (0.5 mg/kg), clozapine (20 mg/kg), remoxipride (1.25 mg/ kg), thioridazine (10 mg/kg), or vehicle in a volume of 1 ml/kg. These doses represent about 5-10 x ED50 for blockade of apomorphine-induced hyperactivity in rats (28). Several pilot studies were carried out to determine the time course of drug-induced alterations in NT/N and c-fos mRNA expression.…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, haloperidol and clozapine significantly increased NT/N mRNA expression in the shell sector of the nucleus accumbens, a predominantly (27) was used as an atypical antipsychotic compound. Finally, the effects of thioridazine were studied since it appears to have a significantly lower propensity to induce acute dystonias in humans and possesses a somewhat atypical profile in animal studies (28).…”

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confidence: 99%

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Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics.

Merchant

Dorsa

1993

Proc. Natl. Acad. Sci. U.S.A.

157

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Precise neural mechanisms underlying the pathophysiology and pharmacotherapy of psychotic disorders remain largely unknown. Present studies investigated the effects of various antipsychotic drugs on expression of the gene encoding the purported endogenous antipsychotic-like peptide neurotensin (NT) Antipsychotic drugs are a group of chemically diverse compounds that are used in the treatment of schizophrenia and other psychotic disorders. Clinical use of several of these drugs termed typical antipsychotics or neuroleptics (e.g., haloperidol and fluphenazine) is accompanied by a wide spectrum of acute and chronic motor side effects such as dystonias and tardive dyskinesia, respectively. These side effects are thought to be mediated by extrapyramidal motor systems in the basal ganglia. The symptoms are often severe and disabling and frequently lead to patient noncompliance. Therefore, recent search for new antipsychotic agents has focused on the so-called "atypical" antipsychotics, drugs that do not cause extrapyramidal motor side effects (EPS). Clozapine is a prototype of atypical antipsychotic drugs whose clinical efficacy is equal to or greater than that of typical antipsychotics such as haloperidol but has a much lower incidence of EPS (1). However, treatment with clozapine results in 1-2% incidence of agranulocytosis (2) and hence the search for new atypical antipsychotics continues.Development of new therapeutic antipsychotic agents with fewer EPS has been difficult partly because precise neurochemical mechanisms underlying the etiology of schizophrenia and the pharmacological effects of antipsychotic drugs remain unclear (3). A role of dopamine D2 receptors is indicated in the observation that the potency of antipsychotic drugs correlates well with their ability to block the D2 receptors (4, 5). However, attempts to identify abnormalities in D2 receptor expression in drug-naive schizophrenic patients have been inconclusive (6, 7). Recent studies therefore have attempted to identify other postsynaptic transmitter systems targeted by antipsychotic drugs that may be involved in the etiology and/or pharmacotherapy of schizophrenia.We have examined the interaction of antipsychotic drugs with a peptidergic transmitter, neurotensin (NT), which was isolated first from bovine hypothalamus (8) and has heterogeneous distribution in mammalian brain. NT interacts closely with nigrostriatal and mesolimbic dopamine systems (for reviews, see refs. 9-11). The pharmacological profile of this peptide in rats resembles that of clinically used antipsychotic drugs such as haloperidol and it has been proposed that NT may be an endogenous neuroleptic-like compound (12). Moreover, a potential role for central NT systems in the etiology/pharmacotherapy of schizophrenia is suggested by the observations that NT concentration in the cerebrospinal fluid of some schizophrenic patients is lower than that of controls. Treatment of these patients with antipsychotic drugs is associated with normalization of NT levels to control val...

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Section: Resultsmentioning

confidence: 98%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics.

Merchant

Dorsa

1993

Proc. Natl. Acad. Sci. U.S.A.

157

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“…Glândulas na lâmina própria não foram observadas por nós em nenhum dos casos, provavelmente devido ao fato da localização da biópsia no seio maxilar (parede súpero-lateral ser uma região normalmente desprovida de glându-las), que nesse seio em particular costumam ser encontradas apenas ao redor de seu óstio natural 6,7 . Enfatizando a celularidade da lâmina própria do seio maxilar nesses casos de RSC, podemos dizer que o nosso achado evidente de grande diversidade de elementos celulares concorda com a literatura mundial.…”

Section: Discussionunclassified

Histopatologia da lâmina própria do seio maxilar na rinossinusite crônica

Sarreta

Dorgam

Souza

et al. 2004

Rev. Bras. Otorrinolaringol.

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A rinossinusite crônica é definida de modo simplificado como uma inflamação crônica da mucosa nasossinusal. Objetivo: Na tentativa de entender o porquê das falhas terapêuti-cas. Forma de estudo: Caso-controle. Material e método: Decidimos estudar as alterações inflamatórias ultraestruturais encontradas na lâmina própria do seio maxilar de 13 pacientes portadores de rinossinusite crônica (RSC) e polipose nasossinusal (PNS), submetidos a tratamento cirúrgico. Biópsias da parede súpero-lateral do seio maxilar desses pacientes foram colhidas durante o ato operatório e, após preparação, observadas através de microscopia eletrônica de transmissão. Resultado: Na análise dos dados obtidos, observou-se cinco padrões de resposta inflamatória nas lâminas próprias estudadas inflamatório crônico. Processo inflamatório agudo -1 caso; processo inflamatório não agudo e não crônico -5 casos; processo inflamatório crônico -2 casos; processo inflamató-rio desorganizado -4 casos; processo inflamatório indeterminado -1 caso. Concluindo, a análise dos resultados mostrou que a lâmina própria do seio maxilar desses pacientes esteve infiltrada por células inflamatórias, sem predomí-nio específico de qualquer elemento celular. Elementos glandulares não foram observados nos casos estudados e a fibrose foi notada em quase metade deles, com intensidade variada e localização preferencial logo abaixo do epitélio. Conclusão: Na situação vista, o processo inflamatório não seguiu as etapas normais de evolução, mostrou marcante desorganização do processo inflamatório, dificuldade em caminhar até a resolução do quadro, acompanhando a mesma dificuldade de resolução clínica nos pacientes.

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“…Experimental operative removal of mucous lining in rabbits show regeneration and reepithelialization within 2 weeks, however such regeneration is never complete and results in sparse goblet cells, atypical glands and occasional polyp formation [14].…”

Section: Anatomy and Physiology Of The Maxillary Sinusmentioning

confidence: 99%

Histologic and Tomographic Clinical Report with 13 Years Follow-up of Sinus Augmentation through Caldwell Luc Procedure in a Case of Chronic Sinusitis

Mahesh¹

2017

JOENTR

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Aim: A case report discussing Caldwell Luc sinus augmentation as an adjunct for implant placement in the maxillary posterior and how to manage treatment with 8 year clinical histological and radiological follow up.Purpose: To evaluate the histologic and tomographic prognosis of sinus augmentation through a Caldwell Luc procedure. Materials and Methods:A patient reported with RCT treated tooth with vertical fracture in 16, and long standing sinusitis. During sinus augmentation procedure, 16 was extracted, sinus was approached through the canine fossa, sinus lining was removed and the area grafted with Mineros (Biohorizons, AL, USA), alloderm membrane was placed over the void and passed through the mucosa in a pouch to cover the extraction socket. A Biohorizons external implant 4/15 mm was placed after 8 months and it was loaded after 6 months.Results: histologic and tomographic reports show excellent uptake of graft after eight months, and complete osseointegration between implant and bone interface.Discussion: mucous lining has the property to grow itself within 4 weeks after its complete removal. This property of the lining makes procedures like caldwellluc possible in which its removal can be done, also giving relief from diseases like long standing sinusitis. Bone grafting can also be done with such procedures, enabling increased height, ultimately making implant placement possible. Conclusion:Implant placement in the maxillary molar area may be complicated due to enlargement of the maxillary sinus, crestal resorption due to periodontal issues, and resorption of the residual ridge or a combination of these factors. Osseous agumentation assists in creating a boney bed that can accommodate implant placement allowing utilization of implants in the posterior maxilla.

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Regeneration of Maxillary Sinus Mucosa following Surgical Removal

Cited by 80 publications

References 19 publications

Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics.

Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychotics.

Histopatologia da lâmina própria do seio maxilar na rinossinusite crônica

Histologic and Tomographic Clinical Report with 13 Years Follow-up of Sinus Augmentation through Caldwell Luc Procedure in a Case of Chronic Sinusitis

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