Regeneration of Olfactory Cells.

Degeneration and Regeneration of the Olfactory Epithelium

“…Thus, contrary to his own finding in the rat (1938) he observed regeneration of the olfactory epithelium in the frog. SCHULTZ (1941) showed in monkeys the restoration of the olfactory cells which had been destroyed by 1 % zinc sulfate solution. He further studied (1960) the effect of this drug upon the olfactory epithelium of monkeys (Fig.…”

“…Consequently, it is highly conceivable that some undifferentiated cells increase in number by mitosis, develop and become entirely new sensory neurons under certain favourable circumstances. In this connection, the finding of the "resting olfactory cell" by NAGAHARA (1940), the "blastema cell" by ANDRES (1965,1966), and regeneration of a new olfactory epithelium from the underlying lamina propria by SMITH (1951) and SCHULTZ (1960) cannot be overestimated, and should stimulate research work in the other nervous tissues toward the solution of a very basic problem, regeneration of the neuron.…”

Post‐traumatic Olfactory Dysfunction

“…This agent is known to temporarily obliterate the olfactory epithelium with no permanent side effects. 7 The patient would notice gradual return of the same foul odor. Following several treatments, each associated with significant pain during and after application, the patient began noticing diminished results with persistence of dysosmia despite treatment.…”

Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo

“…Lining portions of the nasal cavity, the OE consists of olfactory receptor neurons, sustentacular and microvillar supporting cells, as well as basal cells, and replaces mature cell types throughout life. Stem and progenitor cells reside in the basal germinal zone of the OE and have been the focus of active investigation (Caggiano et al, 1994;Calof et al, 2002;Cau et al, 1997;Fletcher et al, 2011;Goldstein and Schwob, 1996;Joiner et al, 2015;Leung et al, 2007;Schultz, 1941). However, basic questions remain regarding the identification and regulation of basal cell subsets required for ongoing OE maintenance or homeostasis.…”