Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: A systematic review

Sculean, Anton; Nikolidakis, Dimitris; Schwarz, Frank

doi:10.1111/j.1600-051x.2008.01263.x

Cited by 367 publications

(316 citation statements)

References 45 publications

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“…The GTR membranes must function for at least 4-6 weeks to allow successful regeneration of the periodontal system [34]. The mass loss curves of different electrospun membranes are shown in Fig.…”

Section: In Vitro Biodegradation Of Electrospun Membranesmentioning

confidence: 99%

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

Xue

Liu³

et al. 2014

Biomaterials

330

219

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Email address: sharell@126.com (R. Shi). AbstractInfection is the major reason for guided tissue regeneration/guided bone regeneration (GTR/GBR) membrane failure in clinical application. In this work, we developed GTR/GBR membranes with localized drug delivery function to prevent infection by electrospinning of poly(ε-caprolactone) (PCL) and gelatin blended with metronidazole (MNA). Acetic acid (HAc) was introduced to improve the miscibility of PCL and gelatin to fabricate homogeneous hybrid nanofiber membranes. The effects of the addition of HAc and the MNA content (0,1,5,10,20,30, and 40 wt.% of polymer) on the properties of the membranes were investigated. The membranes showed good mechanical properties, appropriate biodegradation rate and barrier function. The controlled and sustained release of MNA from the membranes significantly prevented the colonization of anaerobic bacteria. Cells could adhere to and proliferate on the membranes without cytotoxicity until the MNA content reached 30%.Subcutaneous implantation in rabbits for 8 months demonstrated that MNA-loaded membranes evoked a less severe inflammatory response depending on the dose of MNA than bare membranes. The biodegradation time of the membranes was appropriate for tissue regeneration. These results indicated the potential for using MNA-loaded PCL/gelatin electrospun membranes as anti-infective GTR/GBR membranes to optimize clinical application of GTR/GBR strategies.

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Section: In Vitro Biodegradation Of Electrospun Membranesmentioning

confidence: 99%

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

Xue

Liu³

et al. 2014

Biomaterials

330

219

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“…Clinically, periodontitis is difficult to treat with a high rate of recurrence. Regeneration of hard and soft tissues lost to disease is limited and not predictable (Murphy and Gunsolley 2003;Reynolds et al 2003;Sculean et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis

Dyke¹,

Hastürk²,

Kantarcı³

et al. 2014

J Dent Res

117

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Therapies to reverse tissue damage from osteolytic inflammatory diseases are limited by the inability of current tissueengineering procedures to restore lost hard and soft tissues. There is a critical need for new therapeutics in regeneration. In addition to scaffolds, cells, and soluble mediators necessary for tissue engineering, control of endogenous inflammation is an absolute requirement for success. Although significant progress has been made in understanding natural resolution of inflammation pathways to limit uncontrolled inflammation in disease, harnessing the biomimetic properties of proresolving lipid mediators has not been demonstrated. Here, we report the use of nano-proresolving medicines (NPRM) containing a novel lipoxin analog (benzo-lipoxin A 4 , bLXA 4 ) to promote regeneration of hard and soft tissues irreversibly lost to periodontitis in the Hanford miniature pig. In this proof-of-principle experiment, NPRM-bLXA 4 dramatically reduced inflammatory cell infiltrate into chronic periodontal disease sites treated surgically and dramatically increased new bone formation and regeneration of the periodontal organ. These findings indicate that NPRM-bLXA 4 is a mimetic of endogenous resolving mechanisms with potent bioactions that offers a new therapeutic tissue-engineering approach for the treatment of chronic osteolytic inflammatory diseases.

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“…По данным литературы, выраженность образова-ния костной ткани при применении остеопластических материалов достаточно высока и составляет 12,3-78,7% в течение 4-6-месячного периода заживления [9][10][11]. Результаты нашего исследования подтверждают эти данные и демонстрируют высокую эффективность применения остеопластических материалов Gen-os и Apatos для ремоделирования костной ткани челюсти при операциях костной аугментации.…”

Section: заключениеunclassified

Clinical and morphological evaluation of the quality of the jaw bone when using osteoplastic materials in preparation for dental implantation

Kannoeva¹,

Ushakov²,

Zoryan³

2015

Ross. stomatol.

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Regeneration of periodontal tissues: combinations of barrier membranes and grafting materials – biological foundation and preclinical evidence: A systematic review

Cited by 367 publications

References 45 publications

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

Drug loaded homogeneous electrospun PCL/gelatin hybrid nanofiber structures for anti-infective tissue regeneration membranes

Proresolving Nanomedicines Activate Bone Regeneration in Periodontitis

Clinical and morphological evaluation of the quality of the jaw bone when using osteoplastic materials in preparation for dental implantation

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