Regeneration of Skeletal Muscle Fibers and Regulation of Myosatellitocytes Metabolism

Hashchyshyn, V.; Tymochko-Voloshyn, R.; Параняк, Наталія; Vovkanych, L.; Trach, V.; Muzyka, F.; Serafyn, Y.; Prystupa, E.; Boretsky, Y.

doi:10.3103/s0095452722030033

Cited by 2 publications

(2 citation statements)

References 61 publications

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“…(Zhang et al, 2020). Саме M2-макрофаги стимулюють процеси диференціації та злиття стовбурових клітин м'язової тканини (Zhang et al, 2020;Hashchyshyn et al, 2022). Лактат-поляризовані М2-макрофаги посилюють експресію фактора росту ендотелію судин (VEGF), стимулюючи таким чином ангіогенез, що поліпшує транспорт кисню та поживних речовин до м'язової тканини, яка регенерує.…”

Section: перенесення лактату між тканинами організму та його участь у...unclassified

Lactic acid as a systemic product and biomarker of physical load

et al. 2023

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This paper presents an up-to-date review of research data on the specific features of lactic acid metabolism and its role as an effector of vital regulatory mechanisms. Lactic acid is an alpha-hydroxy monocarboxylic acid. Physical loads of submaximal intensity and some diseases can cause dramatic increase of lactic acid content in the body fluids. The excessive lactate is removed from the working muscle and either metabolized by other tissues or excreted from the human body. Alteration of the lactate-pyruvate balance is one of the main markers of the development of cardiac hypertrophy and failure. The redistribution of lactate between the cells producing it and the cells that metabolize it is vital to maintain a stable pH level in tissues and hold lactate in the body since this compound is an important energy source as well as an effector of important regulatory mechanisms. The quantification of lactate is used to assess general physical capabilities of the human body, the intensity of physical load and the rate of recovery in physical rehabilitation. Specialized proteins, which refer to the group of monocarboxylate transporters, are involved in lactate excretion and absorption by cells. The presence of various types of transporters in cell membranes that differ in affinity to lactate and the direction of transport ensures a rapid redistribution of lactic acid throughout the body and regulates the intensity and direction of its metabolism according to the physiological needs. Efficient transfer and redistribution of lactate between different tissues of the body is essential, given the participation of lactate in several important regulatory mechanisms. As an effector, lactate is involved in the regulation of angiogenesis, differentiation of myosatellitocytes, regeneration of muscle fibers, polarization of macrophages and the course of inflammatory processes. Besides, lactate participates in epigenetic mechanisms of muscle tissue metabolism regulation. Therefore, lactate is one of the key metabolites in the human body.

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Section: перенесення лактату між тканинами організму та його участь у...unclassified

Lactic acid as a systemic product and biomarker of physical load

et al. 2023

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“…Після мікропошкоджень м'язів міосателітоцити (стовбурові клітини м'язів) активуються, диференціюються і зливаються з м'язовими волокнами, що забезпечує регенерацію м'язової тканини [23,36]. В індукції проліферації стовбурових клітин м'язів значну роль відіграє міокін LIF (інгібуючий фактор лейкемії) [8].…”

Section: м'язи як ендокринний органunclassified

Myokines are one of the key elements of interaction between skeletal muscles and other systems of human body necessary for adaptation to physical loads

Tymochko-Voloshyn¹,

Hashchyshyn²,

Paraniak³

et al. 2023

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Muscle tissue makes up a significant percentage of body weight, and its metabolism affects almost all body systems. Despite a sufficiently large number of physiological observations that confirmed the need for regular physical activity to maintain health, the molecular mechanisms of such an effect remained unestablished for a long time. Results of recent research confirmed that skeletal muscles are an endocrine organ that produces a wide range of bioregulators, which synthesis and excretion are stimulated during exercise. At present, many of these factors that mediate metabolic and physiological responses in muscles and other organs have been identified and named myokines. To date the most studied myokines are: interleukins (IL-6, LIF, IL-4, IL-7, IL-8, and IL-15), myostatin, myonectin (CTRP15), irisin, fibroblast growth factor 21 (FGF21), brain-derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1), follistatin-like protein-1 (FSTL-1), decorin and SPARC (osteonectin). Most of the myokines exert their effects through paracrine and/or autocrine pathways within muscles, and many of them also act as endocrine agents – via lymph and blood. The biological activity of myokines is realized via modulation of the activity of general global regulatory mechanisms, such as the SMAD signaling cascade, p38/MAPK, Erk1/2 MAPK, PI3K/Akt/GSK-3β, cAMP/Akt, AMPK-dependent regulation, and JNK signaling pathway. At the same time, myokines are involved in the regulation of the activity of the myogenic transcription factors MyoD, myf5, myogenin and a number of proteins involved in the sensing and transport of glucose and fatty acids. Myokines play one of the main roles in the interaction between skeletal muscles, liver, bone and adipose tissues. They increase tissues sensitivity to insulin and are involved in the regulation of important metabolic processes such as carbohydrate, protein and lipid metabolism. Myokines play a significant role in the regulation of myogenesis, osteogenesis, thermogenesis, lipolysis, growth and division of muscle and nerve tissue cells, vascularization, etc. Given the fact that the expression of myokines is induced by muscle contraction, their study allows us to reveal the molecular mechanisms realizing the positive effects of physical exertion. Further studies of myokines and their mechanisms of action are necessary for the development of personalized recommendations for the physical activity of people with metabolic diseases in rehabilitation, physical therapy, medical supervision of physical education and sports.

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Regeneration of Skeletal Muscle Fibers and Regulation of Myosatellitocytes Metabolism

Cited by 2 publications

References 61 publications

Lactic acid as a systemic product and biomarker of physical load

Lactic acid as a systemic product and biomarker of physical load

Myokines are one of the key elements of interaction between skeletal muscles and other systems of human body necessary for adaptation to physical loads

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