Regeneration of tooth pulp and dentin : trends and advances

Sharma, Shubham; Sikri, Vimal; Sharma, Neel; Sharma, Vivek M.

doi:10.5214/ans.0972.7531.2010.170109

Cited by 20 publications

(16 citation statements)

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“…It includes CD1a, CD2, CD4, CD11a, CD11b, CD16, CD18, CD31, CD32, CD45, CD45R/B220, CD45RB, CD54, CD62L, CD64, CD80, CD86, CD200R, MHC class I and II and many more. 5 8 26 34 40 Many of them are also maturation and phagocytic markers for macrophages including CD11b, CD45, CD64, CD68, MHC class II etc, which have been identified in different subsets of microglia in pathogenic and normal brain. 13 This correlation is also evident inside the cell as the transcription factors like PU.1 or MafB, required for development of macrophage and DCs from myeloid cells, are also found important for microglial differentiation.…”

Section: Microglial Commonness With Monocyte/macrophage Lineagementioning

confidence: 99%

“…5 26 56 57 From plethora of studies on microglia and associated macrophage like cells in brain it is now evident that microglial population can adopt and act in almost every possible role of myelo-monocytic cell lineage; and in addition they can perform some CNS specific glial functions probably as local adaption in the CNS microenvironment [Fig-2]. 8 58 59 40 This potential for wide variability also indicates for microglial precursor state that can adapt and mature in several potential paths to reach the terminal effector state as needed in CNS.…”

Section: Progenitors Morphs and Their Dynamic Conversionsmentioning

confidence: 99%

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Brain APCs including microglia are only differential and positional polymorphs

Ghosh¹

2010

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The antigen presentation to lymphocytes in brain occurs in two steps. Initially it happens at perivascular spaces by perivascular microglia/macrophage population and finally at the site of inflammation deep into brain parenchyma by the resident microglia. But recent evidence challanges the existing notion of involvement of distinct and different cells at these sites. Studies have shown that many of these microglial cells show dendritic cell phenotype in pathogenic and cytokine driven environment. Different subsets of the cell show wide range of myeloid lineage functions indicating a pre-differentiated status of the cell. Monocytic CD34+/B220+ precursor cells have been transformed to microglial cells in vitro and transplantation of these cells show Iba-1 or F4/80 positivity with microglial phenotypes in vivo in adults. Even they can be converted into dendritic cell like forms. The interconvertability among macrophage-microglia-dendritic cells and final effector maturation according to the microenvironmental cues indicates existence of a pre-mature myeloid cell population concerned with antigen presentation and related functions in brain. With the substantial recent observation this article sketches the idea that brain APCs appearing as macrophage/microglia/DC like forms are derivatives of the same stock in response to their position and microenvironment. And also microglia is never any distinct cells, both in neonatal stage and adults.

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Section: Microglial Commonness With Monocyte/macrophage Lineagementioning

confidence: 99%

Section: Progenitors Morphs and Their Dynamic Conversionsmentioning

confidence: 99%

Brain APCs including microglia are only differential and positional polymorphs

Ghosh¹

2010

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“…Several types of stem cells including dental pulp stem cells (DPSCs), which are more populated in central cell rich zone of the pulp, bone marrow stem cells (BMSCs), stem cells from human exfoliated deciduous teeth (SHED), and stem cells from apical papilla (SCAPs) have exhibited different levels of ability to generate osteoid and odontoid structures (11). SCAPs are the source of primary odontoblasts that are responsible for continuation of root development (12,13) and, as a result of proximity to the periodontal blood supply, can survive pulp necrosis even in the presence of periradicular infection (12,14).…”

mentioning

confidence: 99%

Regenerative Endodontic Treatment (Revascularization) for Necrotic Immature Permanent Molars: A Review and Report of Two Cases with a New Biomaterial

Nosrat

Seifi

Asgary

2011

Journal of Endodontics

257

167

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“…They are known as bioactive materials, due to their capacity of actively participating on both cicatrization and regeneration of bone tissue [74]. This capacity results from the similarity between calcium phosphate materials and the apatites found on bone tissue [23,63,69].…”

Section: Biomaterials Based On Calcium Phosphatementioning

confidence: 99%

Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

Salgado¹,

Sathler²,

Castro³

et al. 2011

JBNB

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Presently, several different graft materials are employed in regenerative or corrective bone surgery. However current misconceptions about these biomaterials, their use and risks may compromise their correct application and development. To unveil these misconceptions, this work briefly reviewed concepts about bone remodeling, grafts classification and manufacturing processes, with a special focus on calcium phosphate materials as an example of a current employed biomaterial. Thus a search on the last decade was performed in Medline, LILACS, Scielo and other scientific electronic libraries using as keywords biomaterials, bone remodeling, regeneration, biocompatible materials, hydroxyapatite and therapeutic risks. Our search showed not only an accelerated biotechnological development that brought significant advances to biomaterials use on bone remodeling treatments but also several therapeutic risks that should not be ignored. The biomaterials specificity and limitations to clinical application point to the current need for developing safer products with better interactions with the biological microenvironments

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Regeneration of tooth pulp and dentin : trends and advances

Cited by 20 publications

References 0 publications

Brain APCs including microglia are only differential and positional polymorphs

Brain APCs including microglia are only differential and positional polymorphs

Regenerative Endodontic Treatment (Revascularization) for Necrotic Immature Permanent Molars: A Review and Report of Two Cases with a New Biomaterial

Bone Remodeling, Biomaterials And Technological Applications: Revisiting Basic Concepts

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