Regenerative Electrodes for Peripheral Nerve Interfacing

Zellmer, Erik R.; Moran, Daniel W.

doi:10.1007/978-981-15-2848-4_18-1

Cited by 2 publications

(3 citation statements)

References 88 publications

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“…[ 37 , 38 , 39 ] These discrepancies are likely due to the incomplete recovery from the nerve damage and transection, which generally causes the reduction of NCV by ≈50%. [ 40 , 41 , 42 , 43 , 44 ]…”

Section: Resultsmentioning

confidence: 99%

“…[37][38][39] These discrepancies are likely due to the incomplete recovery from the nerve damage and transection, which generally causes the reduction of NCV by ≈50%. [40][41][42][43][44] Figure 3f shows the signal amplitudes recorded at the BI-R depending on the stimulation intensity, indicating that the amplitude of the recorded signals increased with increasing stimulation intensity. Additionally, the amplitude of P1 averaged 0.8 mV at 200 μA stimulation, very similar to that of electrically evoked CNAP from the normal rabbits.…”

Section: Efferent Signal Recording With Bionic Interface (Motor Signa...mentioning

confidence: 97%

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Hybrid Bionic Nerve Interface for Application in Bionic Limbs

Cho,

Jeong,

Shin

et al. 2023

Advanced Science

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Intuitive and perceptual neuroprosthetic systems require a high degree of neural control and a variety of sensory feedback, but reliable neural interfaces for long‐term use that maintain their functionality are limited. Here, a novel hybrid bionic interface is presented, fabricated by integrating a biological interface (regenerative peripheral nerve interface (RPNI)) and a peripheral neural interface to enhance the neural interface performance between a nerve and bionic limbs. This interface utilizes a shape memory polymer buckle that can be easily implanted on a severed nerve and make contact with both the nerve and the muscle graft after RPNI formation. It is demonstrated that this interface can simultaneously record different signal information via the RPNI and the nerve, as well as stimulate them separately, inducing different responses. Furthermore, it is shown that this interface can record naturally evoked signals from a walking rabbit and use them to control a robotic leg. The long‐term functionality and biocompatibility of this interface in rabbits are evaluated for up to 29 weeks, confirming its promising potential for enhancing prosthetic control.

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Section: Resultsmentioning

confidence: 99%

Section: Efferent Signal Recording With Bionic Interface (Motor Signa...mentioning

confidence: 97%

Hybrid Bionic Nerve Interface for Application in Bionic Limbs

Cho,

Jeong,

Shin

et al. 2023

Advanced Science

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“…-Regenerative peripheral neural electrodes are designed to interface peripheral nerve fibers that have regenerated through or past their geometry [12]; -Interfascicular electrodes are designed to gain increased access to the neurons without penetrating the perineurium around the fascicles [13]; -Intrafascicular electrodes provide access to small groups of axons within a peripheral nerve fascicle [7]; -Extraneural electrodes are wrapped around nerves and they are the least invasive electrodes [14]. There are four major types of extraneural electrodes: the epineural electrode, the helical electrode, the book electrode, and the cuff electrode [15,16].…”

Section: Introductionmentioning

confidence: 99%

System of Implantable Electrodes for Neural Signal Acquisition and Stimulation for Wirelessly Connected Forearm Prosthesis

Ionescu,

Franti,

Carbunaru

et al. 2024

Biosensors

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There is great interest in the development of prosthetic limbs capable of complex activities that are wirelessly connected to the patient’s neural system. Although some progress has been achieved in this area, one of the main problems encountered is the selective acquisition of nerve impulses and the closing of the automation loop through the selective stimulation of the sensitive branches of the patient. Large-scale research and development have achieved so-called “cuff electrodes”; however, they present a big disadvantage: they are not selective. In this article, we present the progress made in the development of an implantable system of plug neural microelectrodes that relate to the biological nerve tissue and can be used for the selective acquisition of neuronal signals and for the stimulation of specific nerve fascicles. The developed plug electrodes are also advantageous due to their small thickness, as they do not trigger nerve inflammation. In addition, the results of the conducted tests on a sous scrofa subject are presented.

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Regenerative Electrodes for Peripheral Nerve Interfacing

Cited by 2 publications

References 88 publications

Hybrid Bionic Nerve Interface for Application in Bionic Limbs

Hybrid Bionic Nerve Interface for Application in Bionic Limbs

System of Implantable Electrodes for Neural Signal Acquisition and Stimulation for Wirelessly Connected Forearm Prosthesis

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