Regenerative Endodontic Treatment for Necrotic Immature Permanent Teeth

Chueh, Ling-Huey; Ho, Yi‐Ching; Kuo, Tien-Chun; Lai, Wing-Hong; Chen, Yea-Huey Melody; Chiang, Chun-Pin

doi:10.1016/j.joen.2008.10.019

Cited by 207 publications

(212 citation statements)

References 16 publications

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“…There is a growing body of evidence from case reports to suggest that regenerative endodontics may in fact be possible in teeth with pulpal necrosis, apical pathosis, and immature apices (6)(7)(8)(9). This treatment procedure has acquired many names such as pulp revitalization, root canal revascularization, and regenerative endodontic treatment (RET) (2, 9-11).…”

Section: Introductionmentioning

confidence: 99%

“…The most frequent pretreatment diagnosis of these cases was of pulpal necrosis with or without apical periodontitis. Postoperative recalls showed regression of clinical symptoms in addition to radiographic evidence of hard tissue formation and apical closure (6)(7)(8)(9)(10)12). However, the application of nonstandardized 2-dimensional (2D) radiographs to evaluate an increase in root length and dentin thickness should be interpreted with caution because a slight change in the angulation at the preoperative or recall appointment might produce inconsistent images and inaccurate interpretations (12).…”

Section: Introductionmentioning

confidence: 99%

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3-dimensional Analysis of Regenerative Endodontic Treatment Outcome

EzEldeen

Gorp

Dessel

et al. 2015

Journal of Endodontics

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Introduction: A growing body of evidence supports the regeneration potential of dental tissues after regenerative endodontic treatment (RET). Nevertheless, a standard method for the evaluation of RET outcome is lacking. The aim of this study was to develop a standardized quantitative method for RET outcome analysis based on cone-beam computed tomographic (CBCT) volumetric measurements. Methods: Five human teeth embedded in mandibular bone samples were scanned using both an Accuitomo 170 CBCT machine (Morita, Kyoto, Japan) and a SkyScan 1174 micro-computed tomographic (mCT) system (SkyScan, Antwerp, Belgium). For subsequent clinical application, clinical data and low-dose CBCT scans (preoperatively and follow-up) from 5 immature permanent teeth treated with RET were retrieved. In vitro and clinical 3-dimensional image data sets were imported into a dedicated software tool. Two segmentation steps were applied to extract the teeth of interest from the surrounding tissue (livewire) and to separate tooth hard tissue and root canal space (level set methods). In vitro and clinical volumetric measurements were assessed separately for differences using Wilcoxon matched pairs test. Pearson correlation analysis and Bland-Altman plots were used to evaluate the relation and agreement between the segmented CBCT and mCT volumes. Results: The results showed no statistical differences and strong agreement between CBCT and mCT volumetric measurements. Volumetric comparison of the root hard tissue showed significant hard tissue formation. (The mean volume of newly formed hard tissue was 27.9 [AE10.5] mm 3 [P < .05]). Conclusions: Analysis of 3-dimensional data for teeth treated with RET offers valuable insights into the treatment outcome and patterns of hard tissue formation. (J Endod 2015;-:1-8)

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3-dimensional Analysis of Regenerative Endodontic Treatment Outcome

EzEldeen

Gorp

Dessel

et al. 2015

Journal of Endodontics

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“…This procedure can be used instead of applying tri-antibiotic paste to increase wall thickness in the duct and achieve apical closure 18,19 . Although using calcium hydroxide in revascularization processes does not cause pigmentation of the crown, authors such as Banchs and Trope 13 do not recommend it.…”

Section: Comparison Of the Degree Of Coronal Pigmentation In Extractementioning

confidence: 99%

“…Therefore, selection of antibacterial drugs should be based on the most up-to-date information on bacteriological knowledge. It is necessary to use a paste with a combination of antibiotics that have great bactericidal power and do not cause adverse reactions in patients 18 .…”

Section: Comparison Of the Degree Of Coronal Pigmentation In Extractementioning

confidence: 99%

Comparison of the degree of coronal pigmentation in extracted premolars after the application of bi-antibiotic and tri-antibiotic pastes

Mejía

Monterrsa

2015

Joralres

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Abstract:Objective: To compare the degree of pigmentation in coronal extracted premolars after applying bi-antibiotic and tri-antibiotic pastes. Method: Intentional non-probability sampling. A total of 30 healthy premolars which were extracted for orthodontic reasons and met the inclusion criteria were divided into 2 experimental groups and a control group of 10 teeth each. Group I (G1) was treated with bi-antibiotic paste, group II (G2) with tri-antibiotic paste; and group III or control (G3) was treated with saline solution. Two observers previously calibrated took the initial color sample from each tooth by giving them a value corresponding to the shade guide. After access opening and instrumentation, all teeth received the appropriate medication and color records were taken under the same initial light conditions for 30 days after the procedure. The obtained data were compiled into Excel for further descriptive and inferential analysis with SPSS 19.0. ANOVA test was used with a confidence level of 95%. Results: The degree of pigmentation was 1±0.9 in G1, 12.2±1.2 in G2 and 0.9±0.8 in G3. No statistically significant differences were found between G1 and G3 (p=0.8086), but there was between G1 and G2 (p<0.001), and G2 and G3 (p<0.001). Conclusion: The degree of pigmentation with tri-antibiotic paste was higher than the degree of pigmentation with bi-antibiotic paste used as temporary medication. No difference was found between the degree of pigmentation in the group treated with bi-antibiotic and the control group treated with saline solution. Bi-antibiotic paste did not show pigmentation in the crown of the extracted premolars.

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“…Relatos de casos recentes obtiveram sucesso na revascularização pulpar utilizando pastas à base de hidróxido de cálcio Huang, 2006;Cotti et al, 2008;Chueh et al, 2009;Cehreli et al, 2011;Iwaya et al, 2011;Neha et al, 2011;Chen et al, 2012;Nosrat et al, 2013;Soares et al, 2013;Nagata et al, 2014a,b). irreversível a belactamases, inibindo essas enzimas bacterianas que destroem a amoxicilina; com isso, expande-se o espectro de ação antimicrobiano da penicilina, abrangendo bactérias antes resistentes à amoxicilina, por produzirem belactamases (Anvisa, 2014d).…”

Section: Medicações Intracanalunclassified

Influência de medicações intracanal utilizadas em procedimentos endodônticos regenerativos na sobrevivência de células da papila apical in vitro

Oliveira¹

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Oliveira AP. Influence of intracanal medications used in regenerative endodontic procedures on survival of apical papilla cells in vitro [thesis]. São Paulo: Universidade de São Paulo, Faculdade de Odontologia; 2014. Versão Corrigida.Regenerative Endodontic procedures have provided changes in treatment of patients with immature teeth and apical periodontitis enabling full root development and lower incidence of dental fracture. Intracanal dressings are used for disinfection; however, their effect on apical papilla cells is poorly elucidated. Additionally, the effect of these substances on cells previously subjected to proinflammatory condition is still unknown. The aim of this study was to evaluate the cytotoxicity of intracanal dressings used in Endodontics regenerative procedures on cultured human apical papilla cells at physiologic and activated condition. Cell culture was established from the apical papilla removed from an extracted immature third molar. The substances studied were triple antibiotic modified paste: ciprofloxacin, metronidazole and cephalosporin (1:1:1); CFC: ciprofloxacin, metronidazole and calcium hydroxide (1:1:2) and modified CFC: ciprofloxacin , metronidazole and calcium hydroxide (2:2:1). Part of the cells was stimulated previously with lipotheichoic acid (LTA) of Enterococcus faecalis por 7 days. Once plated, cells were exposed to increasing concentration of the medications for 1, 3, 5 and 7 days. Cell viability was evaluated by means of 3-bromide (4.5-dimetiliazol-2-yl) -2.5-difeniltetraze (MTT) and Nitric Oxide (NO) release was assessed by the Griess method. The statistical analysis was done through analysis of variance with 1 criteria (ANOVA) followed by Tukey test with 5% of significance level. Modified CFC was the medication that demonstrated the less cytotoxic effect on cell viabilityat the experimental periods studied while CFC promoted significant decrease on cell viability specially after 7 days of contact. The modified triple antibiotic paste resulted in important alteration of cell viability being considered the most citotoxic. Cellular activation by LTA resulted in increased levels of mitochondrial activity for all medications being more evident at the longer experimental periods. Cellular activation also contributed to higher levels of nitric oxide release. In conclusion, the cytotoxic effect of the tested medications is dependent on concentration, time of contact and cellular condition, being the triple antibiotic modified paste the most cytotoxic in high concentrations leading clinically in the decreased of the cells viability of the apical papilla, decreasing the success of regenerative procedures.

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Regenerative Endodontic Treatment for Necrotic Immature Permanent Teeth

Cited by 207 publications

References 16 publications

3-dimensional Analysis of Regenerative Endodontic Treatment Outcome

3-dimensional Analysis of Regenerative Endodontic Treatment Outcome

Comparison of the degree of coronal pigmentation in extracted premolars after the application of bi-antibiotic and tri-antibiotic pastes

Influência de medicações intracanal utilizadas em procedimentos endodônticos regenerativos na sobrevivência de células da papila apical in vitro

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