Regenerative medicine: current research and perspective in pediatric surgery

Deguchi, Kentaro; Zambaiti, Elisa; Coppi, Paolo De

doi:10.1007/s00383-023-05438-6

Cited by 8 publications

(4 citation statements)

References 207 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main goal of regenerative medicine and tissue engineering is to restore both the structure and functions of the defected tissues [1]. In recent years, novel and more efficient regenerative therapies based on cells and growth factors (GFs) have been developed.…”

Section: The Importance Of Platelet Concentrates (Pcs) In Regenerativ...mentioning

confidence: 99%

“…• PRP 1 -functionalized alginate hydrogels released a higher cumulative amount of PRP 1 compared to PRP 1 -encapsulated alginate hydrogels • Human NPCs 2 loaded into PRP 1 -functionalized alginate hydrogels produced significantly higher amounts of S-GAGs 3 in vitro compared to cells incorporated into PRP 1 -encapsulated alginate hydrogels and plain alginate hydrogels [113] Alginate-based hydrogel • PRP 1 encapsulated into biomaterial…”

Section: Alginate-based Hydrogelmentioning

confidence: 99%

“…• Human ADSCs 6 which were grown on a 3D SF scaffold in a medium supplemented with LAA 7 or PRP 1 possessed a higher ability to produce GAGs 6 when compared to cells grown on such scaffold in a basal medium • After 7 and 21 days of incubation, it was shown that both LAA 7 and PRP 1 were similarly responsible for the increased expression of N-cadherin (CDH2) and COL2A1 in ADSCs 6 grown on a silk-fibroin-based scaffold. Moreover, on day 21, the presence of PRP 1 in the culture medium was also able to inhibit the expression of β-catenin (CTNNB1) and cyclin D (CCND1) in these cells, which is clear evidence of chondrogenic differentiation support.…”

Section: Biomaterials Main Advantagesmentioning

confidence: 99%

See 2 more Smart Citations

Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications

Grzelak,

Hnydka,

Higuchi

et al. 2024

IJMS

View full text Add to dashboard Cite

Platelet concentrates such as platelet-rich plasma, platelet-rich fibrin or concentrated growth factors are cost-effective autologous preparations containing various growth factors, including platelet-derived growth factor, transforming growth factor β, insulin-like growth factor 1 and vascular endothelial growth factor. For this reason, they are often used in regenerative medicine to treat wounds, nerve damage as well as cartilage and bone defects. Unfortunately, after administration, these preparations release growth factors very quickly, which lose their activity rapidly. As a consequence, this results in the need to repeat the therapy, which is associated with additional pain and discomfort for the patient. Recent research shows that combining platelet concentrates with biomaterials overcomes this problem because growth factors are released in a more sustainable manner. Moreover, this concept fits into the latest trends in tissue engineering, which include biomaterials, bioactive factors and cells. Therefore, this review presents the latest literature reports on the properties of biomaterials enriched with platelet concentrates for applications in skin, nerve, cartilage and bone tissue engineering.

show abstract

Section: The Importance Of Platelet Concentrates (Pcs) In Regenerativ...mentioning

confidence: 99%

Section: Alginate-based Hydrogelmentioning

confidence: 99%

Section: Biomaterials Main Advantagesmentioning

confidence: 99%

See 1 more Smart Citation

Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications

Grzelak,

Hnydka,

Higuchi

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Deguchi et al [277] recently reviewed the use of tissue-engineered products with relevant applications to pediatric surgery.…”

Section: Tissue-engineered Productsmentioning

confidence: 99%

Pediatric Drug Development: Reviewing Challenges and Opportunities by Tracking Innovative Therapies

Domingues,

Jarak,

Veiga

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

The paradigm of pediatric drug development has been evolving in a “carrot-and-stick”-based tactic to address population-specific issues. However, the off-label prescription of adult medicines to pediatric patients remains a feature of clinical practice, which may compromise the age-appropriate evaluation of treatments. Therefore, the United States and the European Pediatric Formulation Initiative have recommended applying nanotechnology-based delivery systems to tackle some of these challenges, particularly applying inorganic, polymeric, and lipid-based nanoparticles. Connected with these, advanced therapy medicinal products (ATMPs) have also been highlighted, with optimistic perspectives for the pediatric population. Despite the results achieved using these innovative therapies, a workforce that congregates pediatric patients and/or caregivers, healthcare stakeholders, drug developers, and physicians continues to be of utmost relevance to promote standardized guidelines for pediatric drug development, enabling a fast lab-to-clinical translation. Therefore, taking into consideration the significance of this topic, this work aims to compile the current landscape of pediatric drug development by (1) outlining the historic regulatory panorama, (2) summarizing the challenges in the development of pediatric drug formulation, and (3) delineating the advantages/disadvantages of using innovative approaches, such as nanomedicines and ATMPs in pediatrics. Moreover, some attention will be given to the role of pharmaceutical technologists and developers in conceiving pediatric medicines.

show abstract

Factors affecting graft healing in laryngotracheal reconstruction: a retrospective single-center experience

Sindi,

Alangari,

Akkielah

et al. 2024

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Regenerative medicine: current research and perspective in pediatric surgery

Cited by 8 publications

References 207 publications

Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications

Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications

Pediatric Drug Development: Reviewing Challenges and Opportunities by Tracking Innovative Therapies

Factors affecting graft healing in laryngotracheal reconstruction: a retrospective single-center experience

Contact Info

Product

Resources

About