Regenerative medicine for osteonecrosis of the femoral head

Im, Gun‐Il

doi:10.1302/2046-3758.121.bjr-2022-0057.r1

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…[1][2][3] The occurrence of collapse is a critical factor that determines the ultimate outcome of ONFH, as once it occurs, patients may experience severe pain and functional impairment, ultimately progressing to arthrosis. [4][5][6][7][8][9] Consequently, predicting and preventing collapse is a critical research focus in both basic and clinical research on ONFH. 10 Medical imaging is a promising tool for predicting collapse in patients with ONFH.…”

Section: Introductionmentioning

confidence: 99%

Panoramic heat map for spatial distribution of necrotic lesions

Yang,

He,

Yang

et al. 2024

Bone Joint Res

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AimsIn this study, we aimed to visualize the spatial distribution characteristics of femoral head necrosis using a novel measurement method.MethodsWe retrospectively collected CT imaging data of 108 hips with non-traumatic osteonecrosis of the femoral head from 76 consecutive patients (mean age 34.3 years (SD 8.1), 56.58% male (n = 43)) in two clinical centres. The femoral head was divided into 288 standard units (based on the orientation of units within the femoral head, designated as N[Superior], S[Inferior], E[Anterior], and W[Posterior]) using a new measurement system called the longitude and latitude division system (LLDS). A computer-aided design (CAD) measurement tool was also developed to visualize the measurement of the spatial location of necrotic lesions in CT images. Two orthopaedic surgeons independently performed measurements, and the results were used to draw 2D and 3D heat maps of spatial distribution of necrotic lesions in the femoral head, and for statistical analysis.ResultsThe results showed that the LLDS has high inter-rater reliability. As illustrated by the heat map, the distribution of Japanese Investigation Committee (JIC) classification type C necrotic lesions exhibited clustering characteristics, with the lesions being concentrated in the northern and eastern regions, forming a hot zone (90% probability) centred on the N4-N6E2, N3-N6E units of outer ring blocks. Statistical results showed that the distribution difference between type C2 and type C1 was most significant in the E1 and E2 units and, combined with the heat map, indicated that the spatial distribution differences at N3-N6E1 and N1-N3E2 units are crucial in understanding type C1 and C2 necrotic lesions.ConclusionThe LLDS can be used to accurately measure the spatial location of necrotic lesions and display their distribution characteristics.Cite this article: Bone Joint Res 2024;13(6):294–305.

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