Regenerative medicine in dermatology: biomaterials, tissue engineering, stem cells, gene transfer and beyond

Dieckmann, Christina; Renner, Regina; Milkova, Linda; Simon, Jan C.

doi:10.1111/j.1600-0625.2010.01087.x

Cited by 106 publications

(89 citation statements)

References 191 publications

(200 reference statements)

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“…Today, several collagen-based products for the treatment of large burns or nonhealing wounds exist [149]. Various matrix components and artificial analogues thereof are added to the collagenous scaffolds to improve functionality.…”

Section: Gags In Wound Healingmentioning

confidence: 99%

Regenerative potential of glycosaminoglycans for skin and bone

et al. 2011

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To meet the growing need for tissue replacement materials for our aging population, the development of new adaptive biomaterials is essential. The tissues with the highest demand for implant materials are skin and bone. These tissues share various similarities, including signaling pathways and extracellular matrix composition. Glycosaminoglycans such as hyaluronan and chondroitin sulfate are the major organic extracellular matrix components. They modulate the attraction of skin and bone precursor cells and their subsequent differentiation and gene expression and regulate the action of proteins essential to bone and skin regeneration. The precise action of glycosaminoglycans varies according to their structural composition mainly in respect to the degree of sulfation and polymer length. Changes in the glycosaminoglycan composition are frequently seen in physiological and pathological remodeling processes, such as bone formation or scaring. Here, we review the current state of knowledge of how the most common glycosaminoglycan, chondroitin sulfate and hyaluronan, interact with bone and skin cells, and summarize their potential in tissue engineering for skeletal and skin diseases.

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Section: Gags In Wound Healingmentioning

confidence: 99%

Regenerative potential of glycosaminoglycans for skin and bone

et al. 2011

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“…In this review we are only discussing the existing cell-based and growth factor-based in vitro and in vivo studies and therapies that are at preclinical and clinical level. For readers interested on the remaining regenerative therapies, which are not included in this review, we would like to refer to previous review papers [40,42,43,44,45]. …”

Section: Regenerative Therapies For Skin Wound Managementmentioning

confidence: 99%

“…Regenerative medicine is defined as a novel and fast growing field of biomedical research that focuses on replacing, restoring and regenerating damaged cells, tissues and organs [40]. This can potentially be accomplished using the process of dedifferentiation (which involves terminally differentiated cells reverting back to a less differentiated stage), transdifferentiation (a processes which takes dedifferentiation a step further and cells differentiate into a cell type of another lineage) and reprogramming (which aims to induce differentiated cells into a pluripotent state) [26].…”

Section: Regenerative Therapies For Skin Wound Managementmentioning

confidence: 99%

Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments

Borena

Martens

Broeckx

et al. 2015

Cell Physiol Biochem

172

112

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Mammal skin has a crucial function in several life-preserving processes such as hydration, protection against chemicals and pathogens, initialization of vitamin D synthesis, excretion and heat regulation. Severe damage of the skin may therefore be life-threatening. Skin wound repair is a multiphased, yet well-orchestrated process including the interaction of various cell types, growth factors and cytokines aiming at closure of the skin and preferably resulting in tissue repair. Regardless various therapeutic modalities targeting at enhancing wound healing, the development of novel approaches for this pathology remains a clinical challenge. The time-consuming conservative wound management is mainly restricted to wound repair rather than restitution of the tissue integrity (the so-called “restitutio ad integrum”). Therefore, there is a continued search towards more efficacious wound therapies to reduce health care burden, provide patients with long-term relief and ultimately scarless wound healing. Recent in vivo and in vitro studies on the use of skin wound regenerative therapies provide encouraging results, but more protracted studies will have to determine whether the effect of observed effects are clinically significant and whether regeneration rather than repair can be achieved. For all the aforementioned reasons, this article reviews the emerging field of regenerative skin wound healing in mammals with particular emphasis on growth factor- and stem cell-based therapies.

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“…In addition to resident SCs in the skin, mesenchymal stem cells (MSCs) derived from either the bone marrow or adipose tissue have been shown to accelerate cutaneous wound regeneration. 64,65 MSCs likely participate in wound healing through several mechanisms, including their multipotential differentiation and secretion of cytokines to promote tissue growth and angiogenesis. For example, adipose-derived MSCs injected directly into excisional wounds were shown to differentiate directly into endothelial and epithelial cell types as well as secrete growth factors to enhance neovasculogenesis, thus accelerating the time for wound closure.…”

Section: Stem Cells In Barrier Formation and Restorationmentioning

confidence: 99%