Regenerative medicine in lung diseases: A systematic review

Adamič, Neža; Vengušt, Modest

doi:10.3389/fvets.2023.1115708

Cited by 4 publications

(2 citation statements)

References 94 publications

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“…Regenerative medicine, particularly through strategies such as stem cell therapy and ECM replacement, holds promise for repairing damaged lung tissue [ 130 ]. Ongoing research is focused on developing bioengineered ECM scaffolds that closely mimic the natural lung matrix, providing a conducive environment for tissue regeneration [ 131 ].…”

Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Al-Husinat,

Azzam,

Al Sharie

et al. 2024

Crit Care

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Background Mechanical ventilation, a lifesaving intervention in critical care, can lead to damage in the extracellular matrix (ECM), triggering inflammation and ventilator-induced lung injury (VILI), particularly in conditions such as acute respiratory distress syndrome (ARDS). This review discusses the detailed structure of the ECM in healthy and ARDS-affected lungs under mechanical ventilation, aiming to bridge the gap between experimental insights and clinical practice by offering a thorough understanding of lung ECM organization and the dynamics of its alteration during mechanical ventilation. Main text Focusing on the clinical implications, we explore the potential of precise interventions targeting the ECM and cellular signaling pathways to mitigate lung damage, reduce inflammation, and ultimately improve outcomes for critically ill patients. By analyzing a range of experimental studies and clinical papers, particular attention is paid to the roles of matrix metalloproteinases (MMPs), integrins, and other molecules in ECM damage and VILI. This synthesis not only sheds light on the structural changes induced by mechanical stress but also underscores the importance of cellular responses such as inflammation, fibrosis, and excessive activation of MMPs. Conclusions This review emphasizes the significance of mechanical cues transduced by integrins and their impact on cellular behavior during ventilation, offering insights into the complex interactions between mechanical ventilation, ECM damage, and cellular signaling. By understanding these mechanisms, healthcare professionals in critical care can anticipate the consequences of mechanical ventilation and use targeted strategies to prevent or minimize ECM damage, ultimately leading to better patient management and outcomes in critical care settings.

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Section: Clinical Implications and Future Perspectivesmentioning

confidence: 99%

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Al-Husinat,

Azzam,

Al Sharie

et al. 2024

Crit Care

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“…Regenerative therapies, such as stem cell-based approaches, are another prospective area for therapeutic development. These novel treatments could lung tissue damage incurred by fetal lung development disorders and promote lung regeneration, a concept backed by emerging preclinical and clinical studies demonstrating the potential benefits of stem cell therapies for lung diseases [238][239][240].…”

Section: Exploring Future Research Directions In the Domain Of Fetal ...mentioning

confidence: 99%

Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review

Yaremenko,

Pechnikova,

Porpodis

et al. 2024

JPM

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Fetal lung development is a crucial and complex process that lays the groundwork for postnatal respiratory health. However, disruptions in this delicate developmental journey can lead to fetal lung development disorders, impacting neonatal outcomes and potentially influencing health outcomes well into adulthood. Recent research has shed light on the intriguing association between fetal lung development disorders and the development of adult diseases. Understanding these links can provide valuable insights into the developmental origins of health and disease, paving the way for targeted preventive measures and clinical interventions. This review article aims to comprehensively explore the association of fetal lung development disorders with adult diseases. We delve into the stages of fetal lung development, examining key factors influencing fetal lung maturation. Subsequently, we investigate specific fetal lung development disorders, such as respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and other abnormalities. Furthermore, we explore the potential mechanisms underlying these associations, considering the role of epigenetic modifications, transgenerational effects, and intrauterine environmental factors. Additionally, we examine the epidemiological evidence and clinical findings linking fetal lung development disorders to adult respiratory diseases, including asthma, chronic obstructive pulmonary disease (COPD), and other respiratory ailments. This review provides valuable insights for healthcare professionals and researchers, guiding future investigations and shaping strategies for preventive interventions and long-term care.

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Recent advances in biomaterials for tissue-engineered constructs: Essential factors and engineering techniques

Norouzi,

Saveh Shemshaki,

Norouzi

et al. 2024

Materials Today Chemistry

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Regenerative medicine in lung diseases: A systematic review

Cited by 4 publications

References 94 publications

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Effects of mechanical ventilation on the interstitial extracellular matrix in healthy lungs and lungs affected by acute respiratory distress syndrome: a narrative review

Association of Fetal Lung Development Disorders with Adult Diseases: A Comprehensive Review

Recent advances in biomaterials for tissue-engineered constructs: Essential factors and engineering techniques

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