Regenerative Medicine Perspectives in Polycystic Ovary Syndrome

Arjmand, Babak; Alaei, Setareh; Heravani, Najmeh Foroughi; Alavi-Moghadam, Sepideh; Payab, Moloud; Ebrahimpour, Mahbube; Aghayan, Hamid Reza; Goodarzi, Parisa; Larijani, Bagher

doi:10.1007/5584_2021_623

Cited by 5 publications

(4 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Animal models can also help us understand PCOS's genetic changes and disturbed metabolic pathways. In preliminary clinical stages, they can also be used to test new treatments 13 .…”

Section: Regenerative Medicine: Stem Cell Therapymentioning

confidence: 99%

Polycystic ovary syndrome: emerging stem cell therapies

Busari,

Tulay

2024

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

“…Animal models can also help us understand PCOS's genetic changes and disturbed metabolic pathways. In preliminary clinical stages, they can also be used to test new treatments 13 .…”

Section: Regenerative Medicine: Stem Cell Therapymentioning

confidence: 99%

Polycystic ovary syndrome: emerging stem cell therapies

Busari,

Tulay

2024

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

“…According to the results of this study, stem cells reduced the androgen levels and TNF-α expression. In another study on the intrauterine injection of BM-hMSCs, the results showed that IL-10 secretion by BM-hMSCs could reverse the inflammation caused by PCOS and could be considered a new PCOS treatment with the ability to restore fertility in affected individuals [122] .…”

Section: Stem Cell-based Pcos Therapymentioning

confidence: 99%

An overview of the physiopathology and various treatment strategies for polycystic ovary syndrome

Rajabi,

Babaie,

Sadeghzadeh Oskouei

et al. 2023

Reproductive and Developmental Medicine

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS), a common endocrine disorder with metabolic and reproductive consequences, affects a significant percentage of women of reproductive age. Because of its complexity and impact on the quality of life, PCOS requires timely diagnosis and screening for complications. The most common clinical manifestations of PCOS are hirsutism, hyperandrogenism, acne, irregular cycles, amenorrhea, and anovulation. Although PCOS has different clinical manifestations in women, hyperandrogenism, and anovulation are the most common symptoms. A good medical history, examination, blood tests, and ultrasound findings facilitate the diagnosis of PCOS. Novel treatments have also undergone clinical trials to improve the symptoms of PCOS. However, comprehensive review articles investigating the different communities of this disease are limited, and this review aimed to collect data on the different etiologies of PCOS along with the latest diagnostic methods and the most common and up-to-date treatments for this disease.

show abstract

“…Regenerative medicine is the science of constructing biological tissues in an in vitro environment using stem cells, biocompatible materials, and biochemical factors, and these tissues are similar to those in the body [ 72 ]. These manufactured tissues are used to study the mechanisms and diagnostic processes as well as probable treatments of the diseases [ 72 – 76 ]. Moreover, they are utilized to develop extracorporeal life support systems or to be implanted into the body to replace a damaged organ or repair injuries [ 72 ].…”

Section: Organoids and Regenerative Medicinementioning

confidence: 99%

Advancement of Organoid Technology in Regenerative Medicine

Arjmand

Rabbani

Soveyzi

et al. 2022

Regen. Eng. Transl. Med.

Self Cite

View full text Add to dashboard Cite

Purpose Organoids are three-dimensional cultures of stem cells in an environment similar to the body’s extracellular matrix. This is also a novel development in the realm of regenerative medicine. Stem cells can begin to develop into 3D structures by modifying signaling pathways. To form organoids, stem cells are transplanted into the extracellular matrix. Organoids have provided the required technologies to reproduce human tissues. As a result, it might be used in place of animal models in scientific study. The key goals of these investigations are research into viral and genetic illnesses, malignancies, and extracellular vesicles, pharmaceutical discovery, and organ transplantation. Organoids can help pave the road for precision medicine through genetic editing, pharmaceutical development, and cell therapy. Methods PubMed, Google Scholar, and Scopus were used to search for all relevant papers written in English (1907–2021). The study abstracts were scrutinized. Studies on the use of stem-cell-derived organoids in regenerative medicine, organoids as 3D culture models for EVs analysis, and organoids for precision medicine were included. Articles with other irrelevant aims, meetings, letters, commentaries, congress and conference abstracts, and articles with no available full texts were excluded. Results According to the included studies, organoids have various origins, types, and applications in regenerative and precision medicine, as well as an important role in studying extracellular vesicles. Conclusion Organoids are considered a bridge that connects preclinical studies to clinical ones. However, the lack of a standardized protocol and other barriers addressed in this review, hinder the vast use of this technology. Lay Summary Organoids are 3D stem cell propagations in biological or synthetic scaffolds that mimic ECM to allow intercellular or matrix-cellular crosstalk. Because these structures are similar to organs in the body, they can be used as research models. Organoids are medicine’s future hope for organ transplantation, tumor biobank formation, and the development of precision medicine. Organoid models can be used to study cell-to-cell interactions as well as effective factors like inflammation and aging. Bioengineering technologies are also used to define the size, shape, and composition of organoids before transforming them into precise structures. Finally, the importance of organoid applications in regenerative medicine has opened a new window for a better understanding of biological research, as discussed in this study.

show abstract

Regenerative Medicine Perspectives in Polycystic Ovary Syndrome

Cited by 5 publications

References 71 publications

Polycystic ovary syndrome: emerging stem cell therapies

Polycystic ovary syndrome: emerging stem cell therapies

An overview of the physiopathology and various treatment strategies for polycystic ovary syndrome

Advancement of Organoid Technology in Regenerative Medicine

Contact Info

Product

Resources

About