Regenerative medicine strategies

Atala, Anthony

doi:10.1016/j.jpedsurg.2011.10.013

Cited by 138 publications

(114 citation statements)

References 93 publications

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“…Many studies investigating the electrospun fibrous scaffolds were focused on the biocompatibility of scaffolds which is especially actual for the generation of tissue-like constructs in vitro (Lim and Mao 2009). However, regardless of all technical problems of scaffold manufacturing, the stem cells and their functioning on the scaffold surface is another critical step for the development of bioactive scaffold (Atala 2012;Chang and Wangs 2011).…”

Section: Scaffolds and Nanotechnologiesmentioning

confidence: 99%

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

et al. 2015

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During the last decade biomaterial sciences and tissue engineering have become new scientific fields supplying rising demand of regenerative therapy. Tissue engineering requires consolidation of a broad knowledge of cell biology and modern biotechnology investigating biocompatibility of materials and their application for the reconstruction of damaged organs and tissues. Stem cell-based tissue regeneration started from the direct cell transplantation into damaged tissues or blood vessels. However, it is difficult to track transplanted cells and keep them in one particular place of diseased organ. Recently, new technologies such as cultivation of stem cell on the scaffolds and subsequently their implantation into injured tissue have been extensively developed. Successful tissue regeneration requires scaffolds with particular mechanical stability or biodegradability, appropriate size, surface roughness and porosity to provide a suitable microenvironment for the sufficient cell-cell interaction, cell migration, proliferation and differentiation. Further functioning of implanted cells highly depends on the scaffold pore sizes that play an essential role in nutrient and oxygen diffusion and waste removal. In addition, pore sizes strongly influence cell adhesion, cell-cell interaction and cell transmigration across the membrane depending on the various purposes of tissue regeneration. Therefore, this review will highlight contemporary tendencies in application of non-degradable scaffolds and stem cells in regenerative medicine with a particular focus on the pore sizes significantly affecting final recover of diseased organs.

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Section: Scaffolds and Nanotechnologiesmentioning

confidence: 99%

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

et al. 2015

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“…K, Na, Ca, Mg. Ca 2+ ions level governs the intra-and inter-cellular communications, blood coagulation and muscle contraction, Mg 2+ ions support photosynthesis, the electron transfer routes are generally based on Fe proteins, transport of oxygen requires Fe and Cu containing proteins, Zn has the main role in regulation of DNA transcription are only some cases which highlight the importance of them [62][63][64][65][66].…”

Section: Biomaterials In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

Peter¹,

Matekovits²,

Rosso³

2018

Biomaterials in Regenerative Medicine

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In all cases, when a material has to be used in medical applications, the knowledge of its physical, chemical and biological properties is of fundamental signiicance, since the direct contact between the biological system and the considered device could generate reactions whose long-term efects must be clearly quantiied. The class of materials that exhibits characteristics that allow their use for the considered applications are commonly called biomaterials. Patients sufering from diferent diseases generate a great demand for real therapies, where the use of biomaterials are mandatory. Commonly, metallic biomaterials are used because their structural functions; the high strength and resistance to fracture they can ofer, provide reliable performance primarily in the ields of orthopedics and dentistry.In metals, because of their particular structure, plastic deformation takes place easier, inducing good formability in manufacturing. The present paper is not encyclopaedic, but reports in the irst part some current literature data and perspectives about the possibility of use diferent class of metallic materials for medical applications, while the second part recalls some results of the current research in this ield carried out by the authors.

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“…The two main approaches in regenerative medicine are; stem cell therapy, which means stimulating regeneration by injecting functional cells into the damaged site, and tissue engineering defined as formation of new tissues by using biocompatible materials [1]. Considerable progress has been made within the field of airway tissue engineering in recent years and the first tissue trachea transplant was performed by Macchiarini et al in 2008 [2].…”

Section: Introductionmentioning

confidence: 99%

Current status of tracheal tissue engineering

Kumbasar¹,

Uysal²

2017

Curr Thorac Surg

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Management of large airway defects is challenging for clinicians due to lack of effective treatment modalities and eventually interest has turned to the field of airway tissue engineering. Considerable progress has been made within the field of airway tissue engineering in recent years and herein we review these recent advances within this field as applied to regeneration and/or replacement of the trachea. Although there are many encouraging researches, we are still far from any routine clinical application of tissue engineered tracheal grafts and it is essential to perform further experimental and clinical researches in order to improve current results and to broaden the clinical application of airway tissue engineering.

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Regenerative medicine strategies

Cited by 138 publications

References 93 publications

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

Scaffolds and cells for tissue regeneration: different scaffold pore sizes—different cell effects

Up-to-Date Knowledge and Outlooks for the Use of Metallic Biomaterials: Review Paper

Current status of tracheal tissue engineering

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