Regenerative periodontal therapy of infrabony defects using minimally invasive surgery and a collagen‐enriched bovine‐derived xenograft: a 1‐year prospective study on clinical and aesthetic outcome

Cosyn, Jan; Cleymaet, Roberto; Hanselaer, Lore; Bruyn, Hugo De

doi:10.1111/j.1600-051x.2012.01924.x

Cited by 33 publications

(48 citation statements)

References 33 publications

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“…The minimally invasive surgical technique (MIST) was used in eleven studies by different authors (Aimetti et al, ; Cortelini et al, ; Cortellini et al, ; Cortellini & Tonetti, , ; Cortellini & Tonetti, , ; Cosyn et al, ; De Bruyckere et al, ; Ghezzi et al, ; Ribeiro, Casarin, Palma, et al, 2011a; Ribeiro, Casarin, Palma, et al, 2011b; Ribeiro et al, , ), with the aid of an operating microscope. It consists of an envelope full‐thickness flap extended to the buccal and lingual aspects of the two teeth adjacent to the defect to expose 1–2 mm of the residual bone crest; flaps are then repositioned without any coronal displacement, and the suturing approach consists of a single modified internal mattress suture.…”

Section: Resultsmentioning

confidence: 99%

Clinical performance of minimally invasive periodontal surgery in the treatment of infrabony defects: Systematic review and meta‐analysis

Clementini

Ambrosi

Cicciarelli

et al. 2019

J Clinic Periodontology

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Aim To assess the effectiveness, in terms of clinical performance and patient perception, of minimally invasive periodontal surgeries (MIPSs), and to compare MIPSs to traditional surgery in the treatment of periodontal infrabony defects. Materials and Methods An electronic search and a manual search were carried out to identify studies investigating clinical (CAL, PPD, REC), radiographic (bone fill) and patient's centred (VAS) outcomes at least 6 months after MIPSs. A linear mixed‐effect model was used for meta‐analysis. Subgroup analyses were performed according to the study quality (RCT or case series). A meta‐analysis assessing differences in clinical parameters between MIPSs and traditional flaps was also performed. Results Meta‐analysis from the 18 included studies revealed a PPD reduction of 4.24 mm (95% CI = 3.79–4.69 mm), a CAL gain of 3.89 mm (95% CI = 3.42–4.35 mm), a REC increase of 0.44 mm (95% CI = 0.11–0.77 mm), a radiographic bone fill gain of 58.25% (95% CI = 42.30%–74.21%) and a VAS value of 1.16 (95% CI = 0.78–1.54). Based on 2 RCTs, MIPSs are more effective than traditional surgery for PPD reduction (0.93 mm, 95% CI = 1.71–0.15) and CAL gain (1 mm, 95% CI = 1.75–.24). Conclusion Minimally invasive periodontal surgeries may be considered for the treatment of periodontal infrabony defects. However, the real effect cannot be systematically evaluated due to the paucity of studies comparing MIPSs to traditional flap for periodontal reconstructive surgery.

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Section: Resultsmentioning

confidence: 99%

Clinical performance of minimally invasive periodontal surgery in the treatment of infrabony defects: Systematic review and meta‐analysis

Clementini

Ambrosi

Cicciarelli

et al. 2019

J Clinic Periodontology

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“…This ranged between 2 weeks [28] and 6 months [11,29,30]. No studies reported clinical and radiographic measures of intrabony defects before and after NSPT and often (55 % of papers) it was not clear exactly when after NSPT (if carried out) the baseline study measurements were collected.…”

Section: Discussionmentioning

confidence: 99%

“…Only in 133 papers (45 %), the timing of review after non-surgical periodontal therapy was reported. This ranged between 2 weeks [28] and 6 months [11,29,30]. The clinical and radiographic baseline of the studies was usually reported to have been carried out at this stage (2 weeks to 6 months after NSPT), although sometimes it was not clear exactly when the baseline measurements were collected.…”

Section: Nspt Outcomesmentioning

confidence: 99%

Effect and timing of non-surgical treatment prior to periodontal regeneration: a systematic review

et al. 2015

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“…Of note, REC values for conservative/minimally invasive procedures tend to be lower than those reported for access flap surgery/GTR (Tables 2 and 3), suggesting that minimally invasive techniques are better suited for areas requiring preservation of esthetics. Nevertheless, it is important to consider that the presence of either a non‐supportive defect anatomy (OR = 58.8) or thin‐scalloped gingival biotype (OR = 76.9) was identified as a risk factor for REC on the midfacial aspect 88 . These findings have significant implications in the esthetic zone, in which minimizing REC is paramount.…”

Section: The Relationship Of Regenerative Treatment To Endodontic Andmentioning

confidence: 99%

Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop

Kao¹,

Nares

Reynolds

2015

Journal of Periodontology

240

228

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Background: Previous systematic reviews of periodontal regeneration with bone replacement grafts and guided tissue regeneration (GTR) were defined as state of the art for clinical periodontal regeneration as of 2002.Methods: The purpose of this systematic review is to update those consensus reports by reviewing periodontal regeneration approaches developed for the correction of intrabony defects with the focus on patient-, tooth-, and site-centered factors, surgical approaches, surgical determinants, and biologics. This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews.A computerized search of the PubMed and Cochrane databases was performed to evaluate the clinically available regenerative approaches for intrabony defects. The search included screening of original reports, review articles, and reference lists of retrieved articles and hand searches of selected journals.All searches were focused on clinically available regenerative approaches with histologic evidence of periodontal regeneration in humans published in English. For topics in which the literature is lacking, non-randomized observational and experimental animal model studies were used.Therapeutic endpoints examined included changes in clinical attachment level, changes in bone level/fill, and probing depth. For purposes of analysis, change in bone fill was used as the primary outcome measure, except in cases in which this information was not available. The SORT (Strength of Recommendation Taxonomy) grading scale was used in evaluating the body of knowledge.Results: 1) Fifty-eight studies provided data on patient, tooth, and surgical-site considerations in the treatment of intrabony defects. 2) Forty-five controlled studies provided outcome analysis on the use of biologics for the treatment of intrabony defects.Conclusions: 1) Biologics (enamel matrix derivative and recombinant human platelet-derived growth factor-BB plus b-tricalcium phosphate) are generally comparable with demineralized freezedried bone allograft and GTR and superior to open flap debridement procedures in improving clinical parameters in the treatment of intrabony defects. 2) Histologic evidence of regeneration has been demonstrated with laser therapy; however, data are limited on clinical predictability and effectiveness. 3) Clinical outcomes appear most appreciably influenced by patient behaviors and surgical approach rather than by tooth and defect characteristics. 4) Long-term studies indicate that improvements in clinical parameters are maintainable up to 10 years, even in severely compromised teeth, consistent with a favorable/good long-term prognosis. J Periodontol 2015;86(Suppl.):S77-S104.

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Regenerative periodontal therapy of infrabony defects using minimally invasive surgery and a collagen‐enriched bovine‐derived xenograft: a 1‐year prospective study on clinical and aesthetic outcome

Cited by 33 publications

References 33 publications

Clinical performance of minimally invasive periodontal surgery in the treatment of infrabony defects: Systematic review and meta‐analysis

Clinical performance of minimally invasive periodontal surgery in the treatment of infrabony defects: Systematic review and meta‐analysis

Effect and timing of non-surgical treatment prior to periodontal regeneration: a systematic review

Periodontal Regeneration – Intrabony Defects: A Systematic Review From the AAP Regeneration Workshop

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