Regenerative Potential of D- and #948;-Tocotrienol Rich Fraction on Crushed Skeletal Muscle of Diabetic Rats

Elsy, Bijo; Khan, Aijaz Ahmed; Maheshwari, Veena

doi:10.5455/jihp.20170419104224

Cited by 1 publication

(3 citation statements)

References 26 publications

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“…Surgical procedure (Figure 1), sample collection and fixation of tissues were followed the methods as described in our previous studies [7][8][9]. pointing the crushed parts of GM.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…Methods used in Histomorphological measurements and its calculations were same as described in our previous studies [7,8]…”

Section: Histopathology and Histomorphologymentioning

confidence: 99%

“…Our previous studies [7,8] revealed that the individual supplementation of d-α-tocopherol and d-δ-TRF helped to accelerate the skeletal muscle regeneration after crushed injuries. Therefore this present study is designed to assess the effect of co-administration of these compounds on muscle repair in both Promote Regeneration of Skeletal Muscle in Diabetics healthy and diabetic rats by using functional, histopathological, histomorphological and biochemical parameters.…”

Section: Introductionmentioning

confidence: 99%

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Co-Administered Vitamin E Isoforms d-α-tocopherol and d-δ-tocotrienol Rich Fraction Promote Regeneration of Skeletal Muscle in Diabetics

Elsy¹

2018

IJNFS

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In diabetes the structural and functional recovery of skeletal muscle is impaired due to persistent hyperglycemiainduced oxidative stress. Vitamin E is known to be essential antioxidant for maintains the skeletal muscle homeostasis thus preventing oxidative damages. This study is designed to explore the effect of d-α-tocopherol and d-δ-tocotrienol rich fraction (d-δ-TRF) on crushed muscle regeneration in both healthy and diabetic rats. Diabetes was induced through single subcutaneous injection of aqueous alloxan at the dose of 100 mg/kg. Twenty four albino rats were divided into four groups; healthy control, diabetic control, healthy treated and diabetic treated. Treated groups received 100 mg/kg of d-α-tocopherol and d-δ-TRF each, orally, daily for three weeks. Through a horizontal mid-thigh skin incision and splitting of the fascia gluteus maximus was approached and crushed with Kocher's forceps. Skin wound was closed with an absorbable suture. The crush-induced degenerative and regenerative changes in the muscle were studied by assessing the histological features, histomorphological measurements and biochemical analyses at the end of 3 rd weeks. One-way 'ANOVA' and Student's t-test were used for statistical analysis. All results revealed that the vitamin E isoforms have potency to maintain glycemic level, improve the antioxidant capacity and hasten the process of regeneration, revascularization, reinnervation and connective tissue remodeling in skeletal muscle after crush injury. It is therefore, concluded that the vitamin E isoforms are useful nutritional supplements for skeletal muscle functional and structural recovery in both healthy and diabetics.

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“…Surgical procedure (Figure 1), sample collection and fixation of tissues were followed the methods as described in our previous studies [7][8][9]. pointing the crushed parts of GM.…”

Section: Surgical Proceduresmentioning

confidence: 99%

“…Methods used in Histomorphological measurements and its calculations were same as described in our previous studies [7,8]…”

Section: Histopathology and Histomorphologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Co-Administered Vitamin E Isoforms d-α-tocopherol and d-δ-tocotrienol Rich Fraction Promote Regeneration of Skeletal Muscle in Diabetics

Elsy¹

2018

IJNFS

Self Cite

View full text Add to dashboard Cite

show abstract

Regenerative Potential of D- and #948;-Tocotrienol Rich Fraction on Crushed Skeletal Muscle of Diabetic Rats

Cited by 1 publication

References 26 publications

Co-Administered Vitamin E Isoforms d-α-tocopherol and d-δ-tocotrienol Rich Fraction Promote Regeneration of Skeletal Muscle in Diabetics

Co-Administered Vitamin E Isoforms d-α-tocopherol and d-δ-tocotrienol Rich Fraction Promote Regeneration of Skeletal Muscle in Diabetics

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