Regenerative Potential of Hydroxyapatite-Based Ceramic Biomaterial on Mandibular Cortical Bone: An In Vivo Study

Abstract

Reconstruction of bone defects and maintaining the continuity of the mandible is still a challenge in the maxillofacial surgery. Nowadays, the biomedical research within bone defect treatment is focussed on the therapy of using innovative biomaterials with specific characteristics consisting of the body’s own substances. Hydroxyapatite ceramic scaffolds have fully acceptable phase compositions, microstructures and compressive strengths for their use in regenerative medicine. The innovative hydroxyapatite ceramics used by us were prepared using the tape-casting method, which allows variation in the shape of samples after packing hydroxyapatite paste to 3D-printed plastic form. The purpose of our qualitative study was to evaluate the regenerative potential of the innovative ceramic biomaterial prepared using this method in the therapy of the cortical bone of the lower jaw in four mature pigs. The mandible bone defects were evaluated after different periods of time (after 3, 4, 5 and 6 months) and compared with the control sample (healthy cortical bone from the opposite side of the mandible). The results of the morphological, clinical and radiological investigation and hardness examination confirmed the positive regenerative potential of ceramic implants after treatment of the mandible bone defects in the porcine mandible model.

Enhanced Release of Calcium Ions from Hydroxyapatite Nanoparticles with an Increase in Their Specific Surface Area

“…Furthermore, the pycnometric density of the particles gradually increased in line with the time and with the pressure and temperature of the synthesis. The obtained GoHAP nanoparticle samples had a lower density than the theoretical density of hydroxyapatite, which is 3.15 g/cm 3 [79,80]. This correlation was previously found for zirconia (ZrO 2 ) nanoparticles [81] and doped and undoped zinc oxide (ZnO) nanoparticles [82][83][84].…”

Photodeposition of Hydroxyapatite into a Titanium Dioxide Nanotubular Layer Using Ca(EDTA) Complex Decomposition

“…The hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) is the main inorganic constituent of bone tissue. Synthetic HA has been successfully used to fabricate biomaterials, osteogenic coatings, and other materials of biomedical interest [1][2][3][4][5]. There are different methodologies for fabrication of calcium phosphates, such as solid-state syntheses [6][7][8][9], hydrothermal syntheses [10][11][12][13][14][15], biomimetic systems [16][17][18], electrochemical process [19][20][21], and sol-gel methods [5,[22][23][24].…”

Monte Carlo Simulation of TRIM Algorithm in Ceramic Biomaterial in Proton Therapy

“…They are important in the field of biomedicine because of their good and compatible physico-chemical properties with certain parts of the human body [ 16 , 17 , 18 ]. Ceramic applications, especially in the 20th century, have been widely preferred in the field of medicine due to the advances in processing technology [ 19 , 20 , 21 ]. They are preferred over metal-based biomaterials because of their excellent biocompatibility, poor degradability, high melting temperature, non-corrosive, better mechanical properties, and poor plasticity [ 16 ].…”