Regenerative potential of the brain: Composition and forming of regulatory microenvironment in neurogenic niches

Kоmleva, Yu. K.; Кувачева, Н. В.; Malinocskaya, N. A.; Gorina, Ya. V.; Lopatina, Olga; Teplyashina, E. A.; Пожиленкова, Е. А.; Zamay, Anna S.; Моргун, А. В.; Салмина, А. Б.

doi:10.1134/s0362119716080077

Cited by 6 publications

(3 citation statements)

References 100 publications

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“…Subgranular zone (SGZ) of hippocampus and subventricular zone (SVZ) are the main areas of the brain where neurogenesis occurs in adulthood due to presence of neurogenic niches with the optimal microenvironment required for maintenance of populations of NSCs, proliferation of neural progenitor cells (NPCs), further differentiation and migration of cells of neuronal and glial lineages ( 94 , 95 ).…”

Section: Cd157 and Neuroplasticitymentioning

confidence: 99%

CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity

et al. 2020

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Ectoenzyme and receptor BST-1/CD157 has been considered as a key molecule involved in the regulation of functional activity of cells in various tissues and organs. It is commonly accepted that CD157 catalyzes NAD+ hydrolysis and acts as a component of integrin adhesion receptor complex. Such properties are important for the regulatory role of CD157 in neuronal and glial cells: in addition to recently discovered role in the regulation of emotions, motor functions, and social behavior, CD157 might serve as an important component of innate immune reactions in the central nervous system. Activation of innate immune system in the brain occurs in response to infectious agents as well as in brain injury and neurodegeneration. As an example, in microglial cells, association of CD157 with CD11b/CD18 complex drives reactive gliosis and neuroinflammation evident in brain ischemia, chronic neurodegeneration, and aging. There are various non-substrate ligands of CD157 belonging to the family of extracellular matrix proteins (fibronectin, collagen I, finbrinogen, and laminin) whose activity is required for controlling cell adhesion and migration. Therefore, CD157 could control structural and functional integrity of the blood-brain barrier and barriergenesis. On the other hand, contribution of CD157 to the regulation of brain development is rather possible since in the embryonic brain, CD157 expression is very high, whereas in the adult brain, CD157 is expressed on neural stem cells and, presumably, is involved in the neurogenesis. Besides, CD157 could mediate astrocytes’ action on neural stem and progenitor cells within neurogenic niches. In this review we will summarize how CD157 may affect brain plasticity acting as a molecule at the crossroad of neurogenesis, cerebral angiogenesis, and immune regulation.

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Section: Cd157 and Neuroplasticitymentioning

confidence: 99%

CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity

et al. 2020

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“…Собственно нейрональные стволовые клетки располагаются и функционируют внутри сложной структуры, которая называется «нейрогенной нишей». Основные свойства этой ниши обусловлены не только присутствием НСК, но и другими типами клеток, в том числе и эпендимальными клетками [23,37], экстрацеллюлярным матриксом [22,38]. Так, установлено, что взрослая нейрогенная ниша V-SVZ, расположенная в желудочково-субвентрикулярной зоне стенки боковых желудочков, наряду с нервными стволовыми клетками с самообновляющейся и дифференцирующейся способностью содержит также постмитотические многоресничные эпендимальные клетки, являющиеся важным структурным и трофическим компонентом ниши.…”

Section: фундаментальная и клиническая медицина ®unclassified

Brain ependymocytes in neurogenesis and maintaining integrity of blood-cerebrospinal fluid barrier

Успенская¹,

Моргун²,

Осипова³

et al. 2019

Fundamentalʹnaâ i kliničeskaâ medicina

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Here we review the physiology of brain ependymocytes which produce cerebrospinal fluid, regulate neurogenic niches, and contribute to neurogenesis in health and disease. We particularly focus on cilia as these organelles are pivotal to ensure the normal functioning of ependymocytes. The functional activity of ependymocytes is largely defined by their localisation in the central nervous system. Further studies of ependymal cell biology are required to better understand the mechanisms of neurological disorders and to discover novel therapeutic strategies aimed at correcting neurodegeneration and aberrant development of the brain.

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“…Формирование микроокружения, способствующего эффективному нейрогенезу в пределах субгранулярной зоны гиппокампа (SGZ), определяется большим спектром механизмов, в числе которых активность клеток нейрональной, астроглиальной, микроглиальной и эндотелиальной природы [4]. В частности, клетки эндотелия церебральных микрососудов, которые тесно контактируют с нейрональными стволовыми клетками (NSCs) и нейрональными прогениторными клетками (NPCs), обеспечивают селективную проницаемость гематоэнцефалического барьера для молекул, участвующих в регуляции нейрогенного потенциала клеток нейрогенных ниш [5][6][7].…”

Section: Introductionunclassified

Astroglia-mediated regulation of cell development in the model of neurogenic niche in vitro treated with Aβ1-42

et al. 2019

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Neurogenesis is a complex process which governs embryonic brain development and is importants for brain plasticity throughout the whole life. Postnatal neurogenesis occurs in neurogenic niches that regulate the processes of proliferation and differentiation of stem and progenitor cells under the action of stimuli that trigger the mechanisms of neuroplasticity. Cells of glial and endothelial origin are the key regulators of neurogenesis. It is known that physiological neurogeneses is crucial for memory formation, whereas reparative neurogenesis provides partial repair of altered brain structure and compensation of neurological deficits caused by brain injury. Dysregulation of neurogenesis is a characteristics of various neurodevelopmental and neurodegenerative diseases, particularly, Alzheimer's disease which is very important medical and social problem. In the in vitro model of the neurogenic niche using hippocampal neurospheres as a source of stem/progenitor cells and astrocytes, we studied effects of astrocyte activation on the expression of markers of different stages of cell proliferation and differentiation. We found that aberrant mechanisms of development of stem and progenitor cells, caused by the beta-amyloid (Aβ1-42), can be partially restored by targeted activation of GFAP-expressing cells in the neurogenic niche.

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Regenerative potential of the brain: Composition and forming of regulatory microenvironment in neurogenic niches

Cited by 6 publications

References 100 publications

CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity

CD157 and Brain Immune System in (Patho)physiological Conditions: Focus on Brain Plasticity

Brain ependymocytes in neurogenesis and maintaining integrity of blood-cerebrospinal fluid barrier

Astroglia-mediated regulation of cell development in the model of neurogenic niche in vitro treated with Aβ1-42

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