Regenerative Potential of Various Soft Polymeric Scaffolds in the Temporomandibular Joint Condyle

Chin, Adam R.; Gao, Jin; Wang, Yadong; Taboas, Juan M.; Almarza, Alejandro J.

doi:10.1016/j.joms.2018.02.012

Cited by 18 publications

(10 citation statements)

References 15 publications

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“…Wu 等(2014) [7] 裸鼠 * 复合材料纤维蛋白-壳聚糖滑膜间充质干细胞 -Tarafder 等(2016) [14] 兔复合材料聚乳酸-羟基乙酸微球-聚己内酯骨髓间充质干细胞结缔组织生长因子、转化生长因子β3 Bousnaki 等(2018) [31] 细胞复合材料壳聚糖-海藻酸钠牙髓干细胞 -Moura 等(2020) [17] 材料复合材料聚乙二醇丙烯酸酯水凝胶为核的聚己内酯 [45] 。TGF-β1/3 可以在生理状态下通 46] 。Ying 等 [47] [48] 。Dormer 等 [12] 用 PLGA 微球荷载 BMP-2、 TGF-β1，构建梯度渐变支架模仿骨至软骨的过渡，修复了髁突骨软骨的缺损。在软骨细胞分化成熟后，持续 TGF-β作用会激活下游 Smad 1/5/8 通路，最终导致软骨细胞的肥大和软骨内的钙化 [49] 。Li 等 [50] 在细胞水平证 [52][53] 。Nitecka-Buchta 等 [54] 通过临床试验证明 PRP 能够改善临床上 TMJOA 患者肌筋膜疼痛的症状。 MSC 主要通过分化形成成骨细胞和成软骨细胞实现骨软骨的修复，随着技术的发展与深入，发现 MSC 可通过旁分泌调节骨软骨的微环境 [55] 。 Zhang 等 [56] [32] 裸鼠 * 天然高分子材料珊瑚骨髓间充质干细胞碱性成纤维生长因子 (转染) Liu 等(2011) [9] 兔天然高分子材料透明质酸水凝胶无胰岛素生长因子-1 沈佩等(2019) [33] 大鼠天然高分子材料胶原蛋白软骨干细胞 -Dormer 等(2011) [12] 兔人工合成材料聚乳酸-羟基乙酸共聚物微球梯度无骨形态发生蛋白-2、转化生长因子β1 张广德等(2017) [24] 兔 2010) [35] 兔复合材料梯度磷酸三钙-胶原 --刘春栋等( 2012) [18] 兔 * 复合材料透明质酸-聚乳酸关节软骨细胞 -石磊等( 2015) [36] 兔复合材料细胞膜片/PRF 双膜骨髓间充质干细胞富血小板纤维蛋白 Wei 等(2016) [37] 山羊复合材料羟基磷灰石、脱细胞肋骨 --郭延伟等( 2018) [23] 兔复合材料成骨多肽-透明质酸-硫酸软骨素脂肪间充质干细胞转化生长因子β3 (转染) Chin 等(2018) [38] 山羊复合材料聚癸二酸丙三醇酯/明胶 -镁离子 Wang 等(2018) [39] 猪…”

Section: 纤维软骨细胞、滑膜间充质干细胞转化生长因子β3unclassified

Research progress on tissue engineering in repairing temporo-mandibular joint

Wang¹,

Wang²,

Wang³

et al. 2021

J Zhejiang Univ (Med Sci)

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Temporomandibular joint osteoarthritis (TMJOA) is mainly manifested as perforation of temporomandibular joint disc (TMJD) and destruction of condylar osteochondral complex (COCC). In recent years, tissue engineering technology has become one of the effective strategies in repairing this damage. With the development of scaffold material technology, composite scaffolds have become an important means to optimize the performance of scaffolds with the combined advantages of natural materials and synthetic materials. The in situ gelling method with the minimally invasive concept

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Section: 纤维软骨细胞、滑膜间充质干细胞转化生长因子β3unclassified

Research progress on tissue engineering in repairing temporo-mandibular joint

Wang¹,

Wang²,

Wang³

et al. 2021

J Zhejiang Univ (Med Sci)

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“…Prior report of PGS implants were of flat sponges (Chin et al., 2018). Here we made the implant matching the shape of the native sheep TMJ disc.…”

Section: Methodsmentioning

confidence: 99%

“…Many materials have been tested for TMJ disc replacement: (1) polyamide (Springer et al., 2001); (2) polyglycolic acid (PGA) (Wang et al., 2009); (3) flat discs of poly(glycerol sebacate) (PGS) (Chin et al., 2018); (4) polylactic acid (PLA) (Ahtiainen et al., 2013); (5) polytetrafluoroethylene (Lai et al., 2001); (6) silicone sheets (Hartman et al., 1988; Schliephake et al., 1999); (7) other biomaterials, such as collagen hydrogels and decellularized tissues (Brown et al., 2012; Li et al., 2017). However, none of these has progressed to clinical trials.…”

Section: Introductionmentioning

confidence: 99%

A randomized controlled preclinical trial on 3 interposal temporomandibular joint disc implants: TEMPOJIMS—Phase 2

Ângelo

Wang

Morouço

et al. 2021

J Tissue Eng Regen Med

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The effort to develop an effective and safe temporomandibular joint (TMJ) disc substitute has been one of the mainstreams of tissue engineering. Biodegradable customized scaffolds could approach safety and effectiveness to regenerate a new autologous disc, rather than using non‐biodegradable materials. However, it is still technically challenging to mimic the biomechanical properties of the native disc with biodegradable polymers. In this study, new 3D tailored TMJ disc implants were developed: (1) Poly(glycerol sebacate) (PGS) scaffold reinforced with electrospun Poly(εcaprolactone) (PCL) fibers on the outer surface (PGS+PCL); (2) PCL and polyethylene glycol diacrylate (PEGDA) (PCL+PEGDA); and (3) PCL. The TMJ implants were tested in a randomized preclinical trial, conducted in 24 black Merino sheep TMJ, perfoming bilateral interventions. Histologic, imaging, and kinematics analysis was performed. No statistical changes were observed between the PGS+PCL disc and the control group. The PCL+PEGDA and PCL groups were associated with statistical changes in histology (p = 0.004 for articular cartilage mid‐layer; p = 0.019 for structure changes and p = 0.017 for cell shape changes), imaging (p = 0.027 for global appreciation) and dangerous material fragmentation was observed. No biomaterial particles were observed in the multi‐organ analysis in the different groups. The sheep confirmed to be a relevant animal model for TMJ disc surgery and regenerative approaches. The PCL and PCL+PEGDA discs presented a higher risk to increase degenerative changes, due to material fragmentation. None of the tested discs regenerate a new autologous disc, however, PGS+PCL was safe, demonstrated rapid resorption, and was capable to prevent condyle degenerative changes.

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“…Tests included an empty control without an implant, a PGS matrix with magnesium ions, a gelatin matrix with magnesium ions, and a gelatin matrix with magnesium ions and trimagnesium phosphate (TMP) powder. A 3-month recuperation period was given to the goats before tissue samples were taken (Chin et al, 2018). In craniofacial microsomia, the skull and face are asymmetrically developed before birth.…”

Section: Polymer Graft and Composite Therapy In Craniofacial Diseasesmentioning

confidence: 99%

The current regenerative medicine approaches of craniofacial diseases: A narrative review

Tahmasebi

Mohammadi

Alam

et al. 2023

Front. Cell Dev. Biol.

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Craniofacial deformities (CFDs) develop following oncological resection, trauma, or congenital disorders. Trauma is one of the top five causes of death globally, with rates varying from country to country. They result in a non-healing composite tissue wound as they degenerate in soft or hard tissues. Approximately one-third of oral diseases are caused by gum disease. Due to the complexity of anatomical structures in the region and the variety of tissue-specific requirements, CFD treatments present many challenges. Many treatment methods for CFDs are available today, such as drugs, regenerative medicine (RM), surgery, and tissue engineering. Functional restoration of a tissue or an organ after trauma or other chronic diseases is the focus of this emerging field of science. The materials and methodologies used in craniofacial reconstruction have significantly improved in the last few years. A facial fracture requires bone preservation as much as possible, so tiny fragments are removed initially. It is possible to replace bone marrow stem cells with oral stem cells for CFDs due to their excellent potential for bone formation. This review article discusses regenerative approaches for different types of craniofacial diseases.

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Regenerative Potential of Various Soft Polymeric Scaffolds in the Temporomandibular Joint Condyle

Cited by 18 publications

References 15 publications

Research progress on tissue engineering in repairing temporo-mandibular joint

Research progress on tissue engineering in repairing temporo-mandibular joint

A randomized controlled preclinical trial on 3 interposal temporomandibular joint disc implants: TEMPOJIMS—Phase 2

The current regenerative medicine approaches of craniofacial diseases: A narrative review

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