Regenerative strategies for the consequences of myocardial infarction: Chronological indication and upcoming visions

Tajabadi, Maryam; Orimi, Hanif Goran; Ramzgouyan, Maryam Roya; Nemati, Alireza; Deravi, Niloofar; Beheshtizadeh, Nima; Azami, Mahmoud

doi:10.1016/j.biopha.2021.112584

Cited by 14 publications

(9 citation statements)

References 273 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early hospital treatment for MI cases will generally aim to restore blood flow and fulfil myocardial oxygen demands to limit ischemic injury. 1 Despite this recent progress in treatment options, MI remains the primary cause of death worldwide. Ischemiareperfusion injury is the primary mode of MI-induced death, occurring when the blood supply is restored to damaged cardiac tissues.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

“…Ischemia-reperfusion injury is characterized by the onset of a continuous inflammatory response postreperfusion, which in turn exaggerates myocardial apoptosis. 1,2 Although the initial inflammatory responses elicited by MI are necessary for effective tissue repair, the exaggeration of inflammatory cytokine release causes acute tissue remodeling and impairs cardiac function. To provide effective treatments for MI, it is critical to understand the molecular mechanisms that underlie MI-associated tissue injury.…”

Section: Myocardial Infarctionmentioning

confidence: 99%

“…Early hospital treatment for MI cases will generally aim to restore blood flow and fulfil myocardial oxygen demands to limit ischemic injury. 1…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Revisiting miRNA-21 as a Therapeutic Strategy for Myocardial Infarction: A Systematic Review

Sothivelr

Hasan

Saffian

et al. 2022

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

Several types of cardiovascular cells use microRNA-21 (miR-21), which has been linked to cardioprotection. In this study, we systematically reviewed the results of published papers on the therapeutic effect of miR-21 for myocardial infarction. Studies described the cardioprotective effects of miR-21 to reduce infarct size by improving angiogenesis, antiapoptotic, and antiinflammatory mechanisms. Results suggest that cardioprotective effects of miR-21 may work synergistically to prevent the deterioration of cardiac function during postischemia. However, there are other results that indicate that miR-21 positively regulates tissue fibrosis, potentially worsening a postischemic injury. The dual functionalities of miR-21 occur through the targeting of genes and signaling pathways, such as PTEN, PDCD4, KBTBD7, NOS3, STRN, and Spry-1. This review provides insights into the future advancement of safe miR-21-based genetic therapy in the treatment of myocardial infarction.

show abstract

Section: Myocardial Infarctionmentioning

confidence: 99%

Section: Myocardial Infarctionmentioning

confidence: 99%

See 1 more Smart Citation

Revisiting miRNA-21 as a Therapeutic Strategy for Myocardial Infarction: A Systematic Review

Sothivelr

Hasan

Saffian

et al. 2022

Journal of Cardiovascular Pharmacology

View full text Add to dashboard Cite

show abstract

“…Among tissues and organs, the mammalian hearts have the least regenerative capabilities, most of which are lost after 10 years of age in humans [ 3 ]. Given the drastic shortage of donor hearts for transplantation, which is only the radical treatment for severe heart failure (HF), developing new therapeutic strategies for severe forms of heart disease is urgently required but remains elusive in modern cardiac biology and medicine [ 4 ]. In this regard, recent advances in stem cell biology and biotechnologies, such as human pluripotent stem cells (hPSCs) and cardiac tissue engineering, hold great promise for opening novel therapeutic paths to heart regeneration and repair for heart disease [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Progress in Bioengineering Strategies for Heart Regenerative Medicine

Häneke

Sahara

2022

IJMS

View full text Add to dashboard Cite

The human heart has the least regenerative capabilities among tissues and organs, and heart disease continues to be a leading cause of mortality in the industrialized world with insufficient therapeutic options and poor prognosis. Therefore, developing new therapeutic strategies for heart regeneration is a major goal in modern cardiac biology and medicine. Recent advances in stem cell biology and biotechnologies such as human pluripotent stem cells (hPSCs) and cardiac tissue engineering hold great promise for opening novel paths to heart regeneration and repair for heart disease, although these areas are still in their infancy. In this review, we summarize and discuss the recent progress in cardiac tissue engineering strategies, highlighting stem cell engineering and cardiomyocyte maturation, development of novel functional biomaterials and biofabrication tools, and their therapeutic applications involving drug discovery, disease modeling, and regenerative medicine for heart disease.

show abstract

“…Rapid recanalization reduces myocardial damage, but prolonged delay increases irreversible myocardial dysfunction and cell death [3].…”

Section: Introductionmentioning

confidence: 99%

Impact of Time Factor on Wall Motion Abnormalities in Patients with STEMI and Underwent Primary PCI

Khraba

Alarag²,

Elsaidy³

et al. 2022

View full text Add to dashboard Cite

Background: Left ventricular (LV) dysfunction is the single most accurate predictor of death and one of the most common and lethal consequences after ST segment elevation myocardial infarction (STEMI) that has been substantially decreased by primary percutaneous coronary intervention (PCI). This research investigated the impact of duration of ischemia on the severity and improvement of wall motion abnormalities after revascularization and 40-day follow-up. Methods: This study was performed on 60 STEMI patients, treated with 1ry PCI and distributed in two groups; group1: 37 patients presented early before 12h and group II: 23 patients presented late after 12h. Echocardiogram (ECHO) was done for ejection fraction (EF) and resting segmental wall motion abnormalities (RSWMA) detection after revascularization within 24 h of hospitalization and follow up after 40 days. Results: MI complication showed insignificant difference between both groups. Wall motion score index (WMSI) values in group I were significantly decreased relative to group II during the follow-up period (p=0.001). Major improvement in LV ejection fraction from hospital admission to follow-up (p=0.001) in group I from the beginning of chest pain compared to group II. Correlation between time to wire crossing and WMSI showed significant positive correlation after 40 days in group I (p=0.016) with significant negative correlation with EF after 40 days in group I (p=0.018). Conclusions: Ischemic patients with ≤ 12 hours symptoms showed a significant degree of recovery from RWMA on follow up after 40 days.

show abstract

Regenerative strategies for the consequences of myocardial infarction: Chronological indication and upcoming visions

Cited by 14 publications

References 273 publications

Revisiting miRNA-21 as a Therapeutic Strategy for Myocardial Infarction: A Systematic Review

Revisiting miRNA-21 as a Therapeutic Strategy for Myocardial Infarction: A Systematic Review

Progress in Bioengineering Strategies for Heart Regenerative Medicine

Impact of Time Factor on Wall Motion Abnormalities in Patients with STEMI and Underwent Primary PCI

Contact Info

Product

Resources

About