Regenerative therapy by using mesenchymal stem cells-derived exosomes in COVID-19 treatment. The potential role and underlying mechanisms

Farkhad, Najmeh Kaffash; Mahmoudi, Alireza; Mahdipour, Elahe

doi:10.1016/j.reth.2022.03.006

Cited by 6 publications

(9 citation statements)

References 140 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1202 There have been dozens of clinical studies focused on the use of exosome therapy for the treatment of COVID-19 in the past 3 years alone, as well as a growing number for the management and mitigation of "long-COVID." [1203][1204][1205][1206][1207][1208][1209][1210][1211][1212][1213][1214][1215][1216][1217][1218][1219][1220][1221][1222] Despite the fact that there are currently a number of vaccines available to immunize people, scientists worldwide are constantly researching potential treatment approaches to treat infected populations due to the daily discovery of new information regarding the structure, pathogenicity, transmission mechanism, and immunological characteristics of the SARS-CoV-2 virus. 1203-1222…”

Section: Use Of Exosomes In Intervertebral Disc Degenerationmentioning

confidence: 99%

“…Previous studies have showed the potential of exosomes for treating SARS coronavirus infection. [1203][1204][1205][1206][1207][1208][1209][1210][1211][1212][1213][1214][1215][1216][1217][1218][1219][1220][1221][1222] In a study by Kuate et al, 1223 polarization. 1225,1226 The implication of these findings is that exosomes can be a viable alternative to their parental cells.…”

Section: Treatment Of Covid-19 Using Exosomesmentioning

confidence: 99%

“…About 80% of COVID‐19‐affected individuals have minor symptoms that are restricted to the upper respiratory tract, yet in 20% of cases, serious illness results 1202 . There have been dozens of clinical studies focused on the use of exosome therapy for the treatment of COVID‐19 in the past 3 years alone, as well as a growing number for the management and mitigation of “long‐COVID.” 1203–1222 …”

Section: Infectious Diseasesmentioning

confidence: 99%

“…Despite the fact that there are currently a number of vaccines available to immunize people, scientists worldwide are constantly researching potential treatment approaches to treat infected populations due to the daily discovery of new information regarding the structure, pathogenicity, transmission mechanism, and immunological characteristics of the SARS‐CoV‐2 virus 1203–1222 …”

Section: Infectious Diseasesmentioning

confidence: 99%

See 3 more Smart Citations

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Miron,

Estrin,

Sculean

et al. 2024

Periodontology 2000

View full text Add to dashboard Cite

Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. Today exosomes have been applied in numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's disease, post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology disorders, musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), regenerative procedures (antiaging, bone regeneration, cartilage/joint regeneration, osteoarthritis, cutaneous wounds, dental regeneration, dermatology/skin regeneration, erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord injury, vascular regeneration), and cancer therapy (breast, colorectal, gastric cancer and osteosarcomas), immune function (allergy, autoimmune disorders, immune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review is a first of its kind aimed at summarizing the extensive regenerative potential of exosomes over a broad range of diseases and disorders.

show abstract

Section: Use Of Exosomes In Intervertebral Disc Degenerationmentioning

confidence: 99%

Section: Treatment Of Covid-19 Using Exosomesmentioning

confidence: 99%

Section: Infectious Diseasesmentioning

confidence: 99%

Section: Infectious Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Miron,

Estrin,

Sculean

et al. 2024

Periodontology 2000

View full text Add to dashboard Cite

show abstract

“…Despite the pathological role of extracellular vesicles in the spread of the virus throughout the body and the initiation of cytokine storm, extracellular vesicles—in particular, MSC exosomes—are now considered promising therapeutic agents in the treatment of COVID-19 [ 78 ]. Khanh et al [ 79 ] showed that extracellular MSC vesicles reduced the levels of inflammatory cytokines regulated by the SARS-CoV-2 peptide in Calu-3 cells.…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Non-Classical Intercellular Communications: Basic Mechanisms and Roles in Biology and Medicine

Polyakova

Калашникова

Belyavsky

2023

IJMS

View full text Add to dashboard Cite

In multicellular organisms, interactions between cells and intercellular communications form the very basis of the organism’s survival, the functioning of its systems, the maintenance of homeostasis and adequate response to the environment. The accumulated experimental data point to the particular importance of intercellular communications in determining the fate of cells, as well as their differentiation and plasticity. For a long time, it was believed that the properties and behavior of cells were primarily governed by the interactions of secreted or membrane-bound ligands with corresponding receptors, as well as direct intercellular adhesion contacts. In this review, we describe various types of other, non-classical intercellular interactions and communications that have recently come into the limelight—in particular, the broad repertoire of extracellular vesicles and membrane protrusions. These communications are mediated by large macromolecular structural and functional ensembles, and we explore here the mechanisms underlying their formation and present current data that reveal their roles in multiple biological processes. The effects mediated by these new types of intercellular communications in normal and pathological states, as well as therapeutic applications, are also discussed. The in-depth study of novel intercellular interaction mechanisms is required for the establishment of effective approaches for the control and modification of cell properties both for basic research and the development of radically new therapeutic strategies.

show abstract