Regio- and Diastereoselective Hydrophosphination and Hydroamidation of gem-Difluorocyclopropenes
Yuanshuo Zhang,
Limei Tian,
Yali Wang
et al.
Abstract:In this study, concise, efficient, and modular hydrophosphinylation and hydroamidation of gem-difluorocyclopropenes were disclosed in a mild and transition-metal-free pattern. Through this approach, phosphorus, and nitrogen-containing gemdifluorocyclopropanes were produced in moderate to good yields with excellent regio-and diastereoselectivity. Readily available gemdifluorocyclopropenes and nucleophilic reagents, along with inexpensive inorganic bases, were employed. Multiple synthetic applications, including… Show more
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