Regio- and Diastereoselective Synthesis of E-Allylic Amines through Hydroalkylation of Terminal Alkynes
Bofei Wang,
Avijit Hazra,
Gojko Lalic
Abstract:Allylic
amines make up an important class of organic compounds
that have inspired the development of numerous methods for their synthesis.
One of the most effective transformations involves the coupling of
internal alkynes with appropriate nitrogen-containing electrophiles
in the presence of a transition metal catalyst. We have developed
a method that allows transformation of terminal alkynes into allylic
amines through a copper-catalyzed reductive cross coupling with α-chloro
phthalimides. The method has a br… Show more
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