2024
DOI: 10.1021/acscatal.4c00853
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Regio- and Diastereoselective Synthesis of E-Allylic Amines through Hydroalkylation of Terminal Alkynes

Bofei Wang,
Avijit Hazra,
Gojko Lalic

Abstract: Allylic amines make up an important class of organic compounds that have inspired the development of numerous methods for their synthesis. One of the most effective transformations involves the coupling of internal alkynes with appropriate nitrogen-containing electrophiles in the presence of a transition metal catalyst. We have developed a method that allows transformation of terminal alkynes into allylic amines through a copper-catalyzed reductive cross coupling with α-chloro phthalimides. The method has a br… Show more

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