Regioisomeric cryptand stabilized gold supraspheres and elongated dodecahedron supraparticles for reversible host–guest chemistry

Abstract

Addition of cryptand regioisomers 1 and 2 to AuNPs produces supraspheres and elongated dodecahedron supraparticles, respectively, apposite for host–guest chemistry.

Selective Release of Doxorubicin from Cucurbit[8]uril Stabilized Gold Supra‐Pyramid Host at pH of Small Intestine

“…This generation of dual peaks suggested the formation of aggregated or self-assembled gold nanoparticles. [26] Upon further addition of CB [8] in 8 m HCl to AuNP,ared shiftw as observed for the second peak from 650 to 690 nm. In all the cases,t he absorbance change was very rapid and the data were taken after 1min of CB [8] addition.…”

“…In our previouss tudies with gold supra-spheres and elongated dodecahedra,w ee xamined high uptake and release of organic fluorophore depending upon aqueous andn on-aqueous solvents. [26] Formation of supra-particle from AuNP was observed experimentally and theoreticallyt od evelopt he cavity within the supra-structure duringi ts formation. [44] In this current study,w ee xplored this surface disruption concept of supra-pyramids in acidic and non-acidic aqueous medium for the host-guest chemistry for DLBCL-associated multiple drug uptake in the cavity of the supra-pyramid andt heir controlled releasei nt he physiological conditions.…”

“…This disruption has indicated the poor stability of the supra‐pyramid in non‐acidic medium. In our previous studies with gold supra‐spheres and elongated dodecahedra, we examined high uptake and release of organic fluorophore depending upon aqueous and non‐aqueous solvents [26] . Formation of supra‐particle from AuNP was observed experimentally and theoretically to develop the cavity within the supra‐structure during its formation [44] .…”

“…Various organic supramolecular architectures, including cyclodextrins, calix[n]arenes, cryptands and pillar[n]arenes were used as capping ligands to gold nanoparticles for aw ider ange of applicationss uch as sensing, photocatalysis, host-guest chemistry. [22][23][24][25][26][27][28] Notably,c ucurbit[n]urils (CB[n]) have gained much attentionb ecause of their biocompatibility,h ighb inding affinity,l ow toxicities and their ability to assemble into supramolecular nanostructure by capping metal nanoparticles surface. [29][30][31] Combinationd rug therapy,i nw hich multiple drugsa re used for the treatment of as ingle disease with differentt herapeutic outcome, has become one of the dominant strategies in the treatment of the most dreadful diseases,s uch as cancer, [32] HIV/AIDS, [33] and diabetes.…”

“…Various organic supramolecular architectures, including cyclodextrins, calix[ n ]arenes, cryptands and pillar[ n ]arenes were used as capping ligands to gold nanoparticles for a wide range of applications such as sensing, photocatalysis, host–guest chemistry [22–28] . Notably, cucurbit[ n ]urils (CB[ n ]) have gained much attention because of their biocompatibility, high binding affinity, low toxicities and their ability to assemble into supramolecular nanostructure by capping metal nanoparticles surface [29–31] …”