A new interpolation spline with two parameters, called EH interpolation spline, is presented in this paper, which is the extension of the standard cubic Hermite interpolation spline, and inherits the same properties of the standard cubic Hermite interpolation spline. Given the fixed interpolation conditions, the shape of the proposed splines can be adjusted by changing the values of the parameters. Also, the introduced spline could approximate to the interpolated function better than the standard cubic Hermite interpolation spline and the quartic Hermite interpolation splines with single parameter by a new algorithm.