Region-specific alterations of calbindin-D28k immunoreactivity in the rat hippocampus following adrenalectomy and corticosterone treatment

Krugers, Harm J.; Medema, Rikje M.; Postema, Folkert; Korf, Jakob

doi:10.1016/0006-8993(95)00783-m

Cited by 22 publications

(13 citation statements)

References 28 publications

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“…In contrast, the absence of calbindin from superficial pyramidal cells in spite of a pronounced condensation of the cell layer suggests an independent development of these characteristics in the sengi, guinea pig and rabbit CA1. Mechanisms related to age- (Poitier et al, 1994; Villa et al, 1994; de Jong et al, 1996), activity- (Lowenstein et al, 1991; Maglóczky et al, 1997), or hormone-dependent (Krugers et al, 1995; Trejo et al, 2000) changes of calbindin content in hippocampal principal cells may mediate species-specific expression patterns. Deep calbindin+ pyramidal cells are present in CA1 of fox and primates and in the distal and temporal CA1 of mouse and rat.…”

Section: Discussionmentioning

confidence: 99%

The hippocampus of the eastern rock sengi: cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis

et al. 2013

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The brains of sengis (elephant shrews, order Macroscelidae) have long been known to contain a hippocampus that in terms of allometric progression indices is larger than that of most primates and equal in size to that of humans. In this report, we provide descriptions of hippocampal cytoarchitecture in the eastern rock sengi (Elephantulus myurus), of the distributions of hippocampal calretinin, calbindin, parvalbumin, and somatostatin, of principal neuron numbers, and of cell numbers related to proliferation and neuronal differentiation in adult hippocampal neurogenesis. Sengi hippocampal cytoarchitecture is an amalgamation of characters that are found in CA1 of, e.g., guinea pig and rabbits and in CA3 and dentate gyrus of primates. Correspondence analysis of total cell numbers and quantitative relations between principal cell populations relate this sengi to macaque monkeys and domestic pigs, and distinguish the sengi from distinct patterns of relations found in humans, dogs, and murine rodents. Calretinin and calbindin are present in some cell populations that also express these proteins in other species, e.g., interneurons at the stratum oriens/alveus border or temporal hilar mossy cells, but neurons expressing these markers are often scarce or absent in other layers. The distributions of parvalbumin and somatostatin resemble those in other species. Normalized numbers of PCNA+ proliferating cells and doublecortin-positive (DCX+) differentiating cells of neuronal lineage fall within the overall ranges of murid rodents, but differed from three murid species captured in the same habitat in that fewer DCX+ cells relative to PCNA+ were observed. The large and well-differentiated sengi hippocampus is not accompanied by correspondingly sized cortical and subcortical limbic areas that are the main hippocampal sources of afferents and targets of efferents. This points to intrinsic hippocampal information processing as the selective advantage of the large sengi hippocampus.

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Section: Discussionmentioning

confidence: 99%

The hippocampus of the eastern rock sengi: cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis

et al. 2013

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“…Animals that were exposed to this stress-paradigm displayed increased Calbindin-D28k immunoreactivity exclusively in the hippocampal CA1 pyramidal cell layer whereas PV immunoreactivity in the hippocampus was not altered by the stress. Previously we observed that prolonged exposure to high levels of corticosterone was associated with increased CB-immunoreactivity exclusively in the hippocampal CA1 pyramidal cell layer [14,15] which probably reflects increased protein levels of Calbindin-D28k [11]. Since the stress used at present transiently elevates plasma corticosterone levels (unpublished results) one might speculate that (1) corticosterone mediates the increased Calbindin-D28k immunoreactivity following prolonged stress, and (2) the increased immunoreactivity following stress reflects increased protein levels.…”

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confidence: 81%

“…Fax: + 31 (20) 525-7709. corticosteroids increase the capacity to maintain neuronal Ca 2+ homeostasis. High levels of corticosteroids increase the immunoreactivity [14,15], protein levels, and mRNA levels [11] of Calbindin-D28k (CB) which can act as intraneuronal Ca 2+ buffer [16,19,20,27]. In the present study we firstly investigated whether elevation of plasma steroid levels by physiological rather than pharmaceutical treatment alters the immunoreactivity of the calcium binding protein CB and Parvalbumin (PV).…”

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confidence: 99%

Prolonged subordination stress increases Calbindin-D28k immunoreactivity in the rat hippocampal CA1 area

et al. 1996

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Previously we observed that corticosteroids alter Calbindin-D28k immunoreactivity in the rat hippocampus. In the present study we investigated whether prolonged subordination stress, presumably producing elevated plasma corticosterone levels (I) altered the immunocytochemical distribution of the CaZ+-binding proteins Calbindin-D28k (CBir) and Parvalbumin (PVir) in the rat hippocampus. and (2) induced ongoing neurodegenerative changes using a silver impregnation method. Eight days of subordination stress reduced body weight, increased adrenal weight corrected for body weight and reduced thymus weight, indicating its effectiveness to produce a stressful situation. Stress increased CBir selectively in the CAI pyramidal cell layer whereas PVir was not altered. Silver-impregnation revealed no ongoing neurodegenerative changes in any of the hippocampal subfields.

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“…Several lines of evidence indicate that the level of brain calcium‐binding protein calbindin‐D28k (CB) expression can be elevated by social stressful experiences. In fact, hippocampal neurons of juvenile or adult animals submitted to maternal separation (Lephart and Watson, 1999), social challenges (Krugers et al, 1996) or treated directly with corticosterone (Iacopino and Christakos, 1990; Krugers et al, 1995) showed significant increases in CB expression. This CB up‐regulation probably occurs because glucocorticoids (GCs), released by stress‐induced activation of the hypothalamic–pituitary–adrenal axis, can promote Ca 2+ influx through either voltage‐dependent Ca 2+ channels (Zhou et al, 2000) or N ‐methyl‐ d ‐aspartate (NMDA) glutamate receptors (Stein‐Behrens et al, 1994).…”

Section: Methodsmentioning

confidence: 99%

Selegiline (deprenyl) decreases calbindin‐D28k expression in cortical neurons of rats socially deprived during the post‐weaning period

Pascual

Zamora-León

Bustamante

2012

Intl J of Devlp Neuroscience

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Preclinical studies indicate that selegiline (deprenyl), frequently used in some neurodegenerative diseases, exert protective effects on central nervous system neurons of individuals exposed to social isolation (SI). Furthermore, it has been suggested that SI produces neuronal dysfunction due in part to an excessive intracellular Ca(2+) overload. Since the main intracellular Ca(2+) buffering mechanism involves changes in the calcium-binding protein calbindin-D28k (CB), and that CB neuronal expression can increase in response to Ca(2+) transients, we hypothesized that chronic selegiline administration in early socially isolated animals could minimize cell CB expression as an indirect indicator of protective mechanism against Ca(2+) overload. In the present study male rats were weaned at postnatal day 21 (P21) and randomly assigned to social deprivation (SI) or control (SC) environments for 30 days (P21-51). SI animals were further subdivided in two experimental groups: socially deprived-saline (SI-SAL) and socially isolated-selegiline (SI-SEL) for additional 30 days (P52-82). Medial frontal CB immunoreactivity (CB-ir) neurons were quantitatively and qualitatively analyzed. The results obtained indicate that neocortical cells of adult rats submitted to early SI show a significant increase in the number of CB-ir neurons per cortical field, while selegiline treatment significantly reduces this parameter.

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Region-specific alterations of calbindin-D28k immunoreactivity in the rat hippocampus following adrenalectomy and corticosterone treatment

Cited by 22 publications

References 28 publications

The hippocampus of the eastern rock sengi: cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis

The hippocampus of the eastern rock sengi: cytoarchitecture, markers of neuronal function, principal cell numbers, and adult neurogenesis

Prolonged subordination stress increases Calbindin-D28k immunoreactivity in the rat hippocampal CA1 area

Selegiline (deprenyl) decreases calbindin‐D28k expression in cortical neurons of rats socially deprived during the post‐weaning period

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