Region-specific differences in colorectal cancer: Slovakia and Hungary have highest incidence in Europe

Simko, Vlado; Ginter, E

doi:10.4149/bll_2016_013

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…More than threefold variation in endoscopic resources exist among European countries . For instance, Slovakia the current country with the highest ASR incidence and mortality for males still does not have a dedicated screening program for CRC despite the Ministry of Health publishing guidelines to facilitate this process . The realization of these discrepancies has urged many countries to roll out nationwide screening campaigns such as the Republic of Korea and their National Cancer Screening Program which has witnessed a twofold increase in participation over the past decade …”

Section: Discussionmentioning

confidence: 99%

Colorectal cancer—global burden, trends, and geographical variations

Douaiher

Ravipati

Grams

et al. 2017

Journal of Surgical Oncology

222

144

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Section: Discussionmentioning

confidence: 99%

Colorectal cancer—global burden, trends, and geographical variations

Douaiher

Ravipati

Grams

et al. 2017

Journal of Surgical Oncology

222

144

View full text Add to dashboard Cite

show abstract

“…Europe was one of the regions with the highest incidence of CRC (13).The data on colorectal cancer indicate a high prevalence in Central and Eastern Europe. Countries such as Hungary, Slovakia, and Croatia are leading (14). In addition to this, the results of the work also showed an increasing trend in the incidence rate of CRC over the period 2002 to 2019 in both sexes.…”

Section: Incidencementioning

confidence: 55%

Joinpoint analysis of colorectal cancer trend in the Slovakia

PHAM,

PEKARCIKOVA,

EDELSTEIN

et al. 2023

BLL

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OBJECTIVES: The aim of this study is to describe the colorectal cancer trend in the Slovakia between 2002 and 2019. BACKGROUND: In 2020, the Slovakia ranked second among the 10 countries with the highest incidence of colorectal cancer and the highest number of deaths from colorectal cancer (hereafter also referred to as CRC). METHODS: To describe the situation of CRC, indicators of incidence and mortality rates stratifi ed by age and sex for the available time period were chosen. A joinpoint regression software was used to identify changes in the trend of development. RESULTS: During the 18-year follow-up period (2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019), the overall trend in colorectal cancer incidence continued to increase with an overall mean annual change of 1.3 %. The incidence of CRC tended to increase from 50 years of age and increased with age. The most pronounced increasing trend was observed in the age group of 75 years and older (AAPC in men 1.9 %, IS +1.4; +2.5 and in women 2.0 %, IS +1.6; +2.4). CRC mortality remained relatively stable for the entire 18-year period. A decreasing trend in mortality was observed in the 25-49 age group with an overall annual percentage decrease of 0.9 % (IS -1.5; -0.3), while an increasing trend was observed in the 75+ age group with an overall annual percentage increase of 1.0 % (IS +0.8; +1.3). The incidence and mortality rates in men were higher than in women. CONCLUSION: The situation of colorectal cancer trend in the Slovakia has improved compared to the previous period (1971-2001).

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“…Colorectal cancer, diagnosis covering malignant neoplasm occurring in the colon, and the rectum is a disease caused by multiple factors such as genetics, lifestyle, environment, and also socioeconomic status and their epigenetics relations [14]. While the Czech Republic is one of the countries with the highest incidence of CRC in the world [15], it is a convenient environment for conducting research on this matter. Correlation between the presence of different single nucleotide polymorphisms and the risk of colorectal cancer development and prognosis is being investigated in a large number of different genes [16].…”

Section: Discussionmentioning

confidence: 99%

MDR 1 C3435T Gene Polymorphism in Colorectal Cancer

Vašků

2023

BJSTR

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Introduction:Colorectal cancer is one of the most frequent malignancies. Single nucleotide polymorphism may contribute to an increased or decreased cancer risk. The ABCB1/MDR1 gene seems to play an important role in tumor progression. The aim of this study is to associate genotypes and/or alleles of the polymorphism with different phenotypes in CRC patients. Material and Methods:A total of 102 CRC patients were recruited. All the individuals were genotyped for MDR1 C3435T polymorphism. Results:The median survival in CC genotype carriers -CRC women were 1 year whereas in CT and TT group it was 6 years and 7 years. These results suggest that CC genotype is associated with a lower survival rate in CRC women (P=0.04). Significantly higher levels of CEA were found in the CC genotype carriers -CRC women (median CEA 7.9, range 1.3-20.5 μg/l) compared to the CT group (median CEA 1.6; range 0.5-12.1 μg/l) and TT group (median CEA 0.5, range 0.5-0.8 μg/l). P=0.06. The representation of the CT genotype is significantly higher in the T3 group of CRC women. OR for the CT genotype is 12; 95%CI=1.10-1.31; P=0.05. The CT+TT genotype carriers were observed 15 times more frequently in women with low resection (OR=15; 95% CI 1.14-198.05; sensitivity=1, specificity=0.5; power test =0.622; P=0.01).Discussion: Our genotype-phenotype study has brought new data and can also serve for a better understanding of this matter in the future. Our results were significant only in females, although the difference in genotypes/alleles between males and females was not significant. A larger sample would be needed to confirm our results.

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Region-specific differences in colorectal cancer: Slovakia and Hungary have highest incidence in Europe

Cited by 6 publications

References 30 publications

Colorectal cancer—global burden, trends, and geographical variations

Colorectal cancer—global burden, trends, and geographical variations

Joinpoint analysis of colorectal cancer trend in the Slovakia

MDR 1 C3435T Gene Polymorphism in Colorectal Cancer

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