This article provides a contextualisation for the study of relations between the European Union and Africa. We identify seven major trends and drivers that have characterised the literature surrounding the relationship: colonial legacy, meanings of partnership, asymmetry, market liberalisation, politicisation, regional actorness and the changing global order. In the literature, these elements tend to be examined separately or in unidirectional perspectives. This article argues, however, that each element invariably influences both sides, although not necessarily in the same manner or to the same effect. In addition, most elements are intertwined and influence each other. These entanglements become visible when examining all seven elements as part of one context. This article suggests that proceeding on an assumption of mutual influence and highlighting the intertwined nature of the different elements constitutes a framework that serves this special issue's efforts to recalibrate African and European perspectives in the scholarship.