Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats

Laeken, Nick Van; Pauwelyn, Glenn; Dockx, Robrecht; Descamps, Benedicte; Brans, Boudewijn; Peremans, Kathelijne; Baeken, Chris; Goethals, Ingeborg; Vanhove, Christian; Vos, Filip De

doi:10.1007/s00702-018-1899-8

Cited by 13 publications

(9 citation statements)

References 60 publications

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“…Positron emission tomography with 18F-fluorodeoxyglucose ({18F} FDG) in Long-Evans rats chronically treated with corticosterone revealed decreased metabolic activity in the insular cortex and the striatum, but elevation in the cerebellum and midbrain [263]. Moreover, prolonged corticosteroids treatment led to structural changes in rodents' brains, such as reduced hippocampal volume and increased volume of amygdala (reviewed in [160]).…”

Section: Corticosterone Model Of Depressionmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood. Hence, as for most human diseases, animal models can help us understand the pathogenesis of depression and, more importantly, may facilitate the search for therapy. In this review we first describe the more common tests used for the evaluation of depressive-like symptoms in rodents. Then we describe different models of depression and discuss their strengths and weaknesses. These models can be divided into several categories: genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations (i.e., learned helplessness in rats/mice), models induced by changes in brain neuro-transmitters or by specific brain injuries and models induced by pharmacological tools. In spite of the fact that none of the models completely resembles human depression, most animal models are relevant since they mimic many of the features observed in the human situation and may serve as a powerful tool for the study of the etiology, pathogenesis and treatment of depression, especially since only few patients respond to acute treatment. Relevance increases by the fact that human depression also has different facets and many possible etiologies and therapies.

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Section: Corticosterone Model Of Depressionmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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“…In addition, decreased glucose uptake measured by PET in the striatum has been reported in a depression model in rats after chronic corticosterone administration [88]. Decreased CCO activity in brain regions included in the mesolimbic dopamine pathway play a key role in the motivational and/or hedonic processes is associated with anxiety and depression [89,90].…”

Section: Discussionmentioning

confidence: 99%

Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats

González-Pardo¹,

Árias²,

Vallejo³

et al. 2019

PLoS ONE

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Early life stress is associated with long-term and pervasive adverse effects on neuroendocrine development, affecting normal cognitive and emotional development. Experimental manipulations like environmental enrichment (EE) may potentially reverse the effects of early life stress induced by maternal separation (MS) paradigm in rodents. However, the functional brain networks involved in the effects of EE after prolonged exposure to MS have not yet been investigated. In order to evaluate possible changes in brain functional connectivity induced by EE after MS, quantitative cytochrome c oxidase (CCO) histochemistry was applied to determine regional brain oxidative metabolism in adult male rats. Unexpectedly, results show that prolonged MS during the entire weaning period did not cause any detrimental effects on spatial learning and memory, including depressive-like behavior evaluated in the forced-swim test, and decreased anxiety-like behavior. However, EE seemed to alter anxiety- and depression-like behaviors in both control and MS groups, but improved spatial memory in the latter groups. Analysis of brain CCO activity showed significantly lower metabolic capacity in most brain regions selected in EE groups probably associated with chronic stress, but no effects of MS on brain metabolic capacity. In addition, principal component analysis of CCO activity revealed increased large-scale functional brain connectivity comprising at least three main networks affected by EE in both MS and control groups. Moreover, EE induced a pattern of functional brain connectivity associated with stress and anxiety-like behavior as compared with non-enriched groups. In conclusion, EE had differential effects on cognition and emotional behavior irrespective of exposure to MS. In view of the remarkable effects of EE on brain function and behavior, implementation of rodent housing conditions should be optimized by evaluating the balance between scientific validity and animal welfare.

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“…Laeken and co-workers compared [ 18 F]FDG uptake (brain normalised uptake values) after CUMS exposure with tracer uptake after sub-chronic administration of corticosterone (as positive stress control). This study showed that the CUMS protocol displays only partially the brain inactivation/activation pattern that is induced by corticosterone administration [60]. Taken together, these studies indicate that the CUMS model has proven capable not only to induce depressive-like behaviour but also to modify the brain activity measured with [ 18 F]FDG-PET.…”

Section: Chronic-stress Paradigmsmentioning

confidence: 61%

“…No changes [40] Increased # , decreased^ [32] Decreased [21] Decreased [24] Cerebellum Increased [29,48] Increased [60] Decreased [24] *Postero-medial thalamic nuclei. ^These areas were reported as brainstem.…”

Section: Chronic-stress Paradigmsmentioning

confidence: 99%

PET imaging of animal models with depressive-like phenotypes

Vazquez-Matias

Vries

Dierckx

et al. 2023

Eur J Nucl Med Mol Imaging

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Major depressive disorder is a growing and poorly understood pathology. Due to technical and ethical limitations, a significant proportion of the research on depressive disorders cannot be performed on patients, but needs to be investigated in animal paradigms. Over the years, animal studies have provided new insight in the mechanisms underlying depression. Several of these studies have used PET imaging for the non-invasive and longitudinal investigation of the brain physiology. This review summarises the findings of preclinical PET imaging in different experimental paradigms of depression and compares these findings with observations from human studies. Preclinical PET studies in animal models of depression can be divided into three main different approaches: (a) investigation of glucose metabolism as a biomarker for regional and network involvement, (b) evaluation of the availability of different neuroreceptor populations associated with depressive phenotypes, and (c) monitoring of the inflammatory response in phenotypes of depression. This review also assesses the relevance of the use of PET imaging techniques in animal paradigms for the understanding of specific aspects of the depressive-like phenotypes, in particular whether it might contribute to achieve a more detailed characterisation of the clinical depressive phenotypes for the development of new therapies for depression.

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Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats

Cited by 13 publications

References 60 publications

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats

PET imaging of animal models with depressive-like phenotypes

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