Regional Analysis of Ceramides within the Stratum corneum in Relation to Seasonal Changes

Yoshikawa, Nobuko; Imokawa, G.; Akimoto, Kayoko; Jin, Kumi; Higaki, Yuko; Kawashima, Makoto

doi:10.1159/000247141

Cited by 52 publications

(47 citation statements)

References 9 publications

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“…Rogers et al [24] and Niemenen et al [25] reported that the amounts of the intercellular lipids of the SC decreased in winter. In contrast, Yoshikawa et al [26] did not find any such seasonal change in the ceramide level in the SC of mixed sex healthy young adults.…”

Section: Discussionmentioning

confidence: 79%

The Winter Season Affects More Severely the Facial Skin than the Forearm Skin: Comparative Biophysical Studies Conducted in the Same Japanese Females in Later Summer and Winter

Kikuchi

Kobayashi

Fur³

et al. 2002

Exog Dermatol

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Skin disorders such as atopic dermatitis, psoriasis and senile xerosis show a tendency to exacerbate in winter. We investigated the seasonal influence on the functional parameters of the skin in healthy female volunteers of different age groups. Biophysical noninvasive measurements, including transepidermal water loss (TEWL) as a parameter for the barrier function of the stratum corneum (SC), high-frequency conductance as a parameter for the hydration state of the SC, temperature, color and casual surface lipid levels, were conducted during the later summer and winter months in 39 healthy adult Japanese females ranging in age from 24 to 78 years. The measurements were made on the cheek, the exposed area, and flexor forearm, the semicovered area, in the same climate-controlled chamber. The barrier function of the SC was found to be significantly impaired in winter both on the cheek and flexor forearm. This difference between summer and winter was much larger on the cheek than on the forearm. The hydration state of the SC was significantly lower in winter on the flexor forearm, whereas no such seasonal change was apparent on the cheek where sebum levels did not show any seasonal change. We measured the corneocyte size in 24 out of the 39 subjects to estimate a seasonal change of the turnover rate of the SC. It tended to be smaller only on the exposed cheek skin, suggesting an enhanced turnover of the SC in winter, whereas it was somewhat larger on the semicovered flexor forearm. The skin surface temperature and redness were also significantly higher on the cheek in winter. We think that subclinical inflammation resulted in the enhanced turnover rate of the SC associated with elevated TEWL levels observed on the face in winter. In conclusion, the obtained data suggest that the exposed facial skin becomes more irritable under the influence of the dry and cold environment of winter even in healthy individuals where the barrier function of the SC is relatively poor as compared to the skin of other areas.

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Section: Discussionmentioning

confidence: 79%

The Winter Season Affects More Severely the Facial Skin than the Forearm Skin: Comparative Biophysical Studies Conducted in the Same Japanese Females in Later Summer and Winter

Kikuchi

Kobayashi

Fur³

et al. 2002

Exog Dermatol

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“…Skin lipids from the epidermis and seba ceous glands are a permanent research topic in studies dealing with acne and skin barrier function [1][2][3][4][5][6][7], The purpose of our study was to find a new simple, non-invasive technique for sampling and to improve the separation of skin surface lipids, in particular epidermal lipids. The new method is a modification of those described by Melnik [8], Hollmann et al [9] and Melnik et al [10] ( fig.…”

Section: Introductionmentioning

confidence: 99%

Improved Method for Studying Skin Lipid Samples from Cyanoacrylate Strips by High-Performance Thin-Layer Chromatography

Röpke

Augustin²,

Gollnick³

1996

Skin Pharmacol Physiol

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A non-invasive method for sampling skin surface lipids is cyanoacrylate stripping (CAC-TS). It was the purpose of our study to improve the method for sampling of skin surface lipids and the separation of epidermal lipid fractions by a modification of the methods described by Melnik and by Imokawa et al. Briefly, lipids on the glass slide sampled by CAC-TS from the forearm of 75 volunteers and from the forehead of 60 volunteers were eluted in hexane/ethanol under ultrasonication. Identification of the diluted total superficial sebaceous and epidermal skin lipids was performed by sequential high-performance thin-layer chromatography. For quantification of the lipids we used densitometric methods. By this modified method we were able to show a clear and complete separation of all relevant lipids from a cyanoacrylate strip that represented 1-2 mg stratum corneum only.

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“…Yoshikawa et al [13] found in a study with mixed-gender subjects that the absolute amounts of lipids were decreased in winter, whereas the ceramide mass was slightly increased, refl ecting seemingly enhanced keratinization. This study tended to prove that in young adults, the mass of ceramide remains stable even under different sea-sonal conditions, providing maintenance of a water reservoir and barrier function.…”

Section: Winter and Xerosismentioning

confidence: 99%

Dry Skin and the Environment

Mac-Mary¹,

Sainthillier²,

Humbert³

2004

Exog Dermatol

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Dry skin is estimated to be present in about 75% of people aged 75 and over. It has been known for many years that this condition is more frequent in winter, in cold and dry weather conditions. With technological progress, people are now mostly exposed to multiple indoor and outdoor pollutants and environment parameters (air-conditioning, chemicals, noise) which can interact which each other and affect human health, and particularly the skin. All these phenomena are intensified with skin aging and can be aggravated by seasons, the way of life, habits (nutrition, dust, allergens, air-conditioning, noise, smoking, unadapted cosmetic use, some treatments) and working conditions (visual display unit, stress). In fact, this environment can be defined as the whole ensemble of external factors which could have an influence on a subject’s health. This means material (climate, geography), organical (biosphere, fauna, flora), physicocultural (techniques), biocultural (nutritional habits, hygiene, medical use) and psychocultural (stress) elements. The aim of this article is to make a review in order to check which of these elements have a major impact on dry skin, in particular among seasons, working/living conditions and cosmetic or hygienic products.

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Regional Analysis of Ceramides within the Stratum corneum in Relation to Seasonal Changes

Cited by 52 publications

References 9 publications

The Winter Season Affects More Severely the Facial Skin than the Forearm Skin: Comparative Biophysical Studies Conducted in the Same Japanese Females in Later Summer and Winter

The Winter Season Affects More Severely the Facial Skin than the Forearm Skin: Comparative Biophysical Studies Conducted in the Same Japanese Females in Later Summer and Winter

Improved Method for Studying Skin Lipid Samples from Cyanoacrylate Strips by High-Performance Thin-Layer Chromatography

Dry Skin and the Environment

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