Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation

Bauer, Andreas; Zilles, Karl; Matusch, Andreas; Holzmann, Carsten; Rieß, Olaf; Hörsten, Stephan von

doi:10.1111/j.1471-4159.2005.03169.x

Cited by 52 publications

(26 citation statements)

References 40 publications

(100 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, a reduction in striatal D1-receptor density was found in 14 months old tgHD rats (Bode et al, 2008), as well as a decrease in striatal D1 and D2 receptor binding at the age of 24 months (Bauer et al, 2005; Von Hörsten et al, 2003). A reduction of serotonin-containing cells and an increase of dopamine-containing cells were also found in the dorsal raphe nucleus in both human and tgHD rat tissues, inducing a reduced level of serotonin expression in the medial PFC (Jahanshahi et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease

Massioui

Lamirault

Yagüe

et al. 2016

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

Cognitive deficits associated with Huntington disease (HD) are generally dominated by executive function disorders often associated with disinhibition and impulsivity/compulsivity. Few studies have directly examined symptoms and consequences of behavioral disinhibition in HD and its relation with decision-making. To assess the different forms of impulsivity in a transgenic model of HD (tgHD rats), two tasks assessing cognitive/choice impulsivity were used: risky decision-making with a rat gambling task (RGT) and intertemporal choices with a delay discounting task (DD). To assess waiting or action impulsivity the differential reinforcement of low rate of responding task (DRL) was used. In parallel, the volume as well as cellular activity of the amygdala was analyzed. In contrast to WT rats, 15 months old tgHD rats exhibited a poor efficiency in the RGT task with difficulties to choose advantageous options, a steep DD curve as delays increased in the DD task and a high rate of premature and bursts responses in the DRL task. tgHD rats also demonstrated a concomitant and correlated presence of both action and cognitive/choice impulsivity in contrast to wild type (WT) animals. Moreover, a reduced volume associated with an increased basal cellular activity of the central nucleus of amygdala indicated a dysfunctional amygdala in tgHD rats, which could underlie inhibitory dyscontrol. In conclusion, tgHD rats are a good model for impulsivity disorder that could be used more widely to identify potential pharmacotherapies to treat these invasive symptoms in HD.

show abstract

Section: Discussionmentioning

confidence: 99%

Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease

Massioui

Lamirault

Yagüe

et al. 2016

Front. Behav. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, the desensitization of the 5-HT 1A autoreceptor has been demonstrated to be essential for enhanced 5-HT transmission following chronic treatment with selective 5-HT reuptake inhibitors [21]. Finally, 5-HT 1A and/or 5-HT 2 receptor abnormalities have been described in different rodent models of mood disorders [22], [23], [24], [25] and HD [26], [27], [28].…”

Section: Introductionmentioning

confidence: 99%

Sexually Dimorphic Serotonergic Dysfunction in a Mouse Model of Huntington's Disease and Depression

Renoir

Zajac

et al. 2011

PLoS ONE

View full text Add to dashboard Cite

Depression is the most common psychiatric disorder in Huntington's disease (HD) patients. In the general population, women are more prone to develop depression and such susceptibility might be related to serotonergic dysregulation. There is yet to be a study of sexual dimorphism in the development and presentation of depression in HD patients. We investigated whether 8-week-old male and female R6/1 transgenic HD mice display depressive-like endophenotypes associated with serotonergic impairments. We also studied the behavioral effects of acute treatment with sertraline. We found that only female HD mice exhibited a decreased preference for saccharin as well as impaired emotionality-related behaviors when assessed on the novelty-suppressed feeding test (NSFT) and the forced-swimming test (FST). The exaggerated immobility time displayed by female HD in the FST was reduced by acute administration of sertraline. We also report an increased response to the 5-HT1A receptor agonist 8-OH-DPAT in inducing hypothermia and a decreased 5-HT2A receptor function in HD animals. While tissue levels of serotonin were reduced in both male and female HD mice, we found that serotonin concentration and hydroxylase-2 (TPH2) mRNA levels were higher in the hippocampus of males compared to female animals. Finally, the antidepressant-like effects of sertraline in the FST were blunted in male HD animals. This study reveals sex-specific depressive-related behaviors during an early stage of HD prior to any cognitive and motor deficits. Our data suggest a crucial role for disrupted serotonin signaling in mediating the sexually dimorphic depression-like phenotype in HD mice.

show abstract

“…Tissue sections were dried under a gentle stream of cool air. Slides were arrayed in X-ray cassettes together with tritium standards (Amersham Pharmacia Biotech, Piscataway, NJ, USA) and were exposed to tritium-sensitive film (Kodak hyperfilm; Eastman Kodak) at room temperature for 2 or 3 months (13–15). Films were developed and fixed at room temperature (Table I).…”

Section: Methodsmentioning

confidence: 99%

Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake

Manuel‐Apolinar

Rocha²,

Damasio

et al. 2013

Molecular Medicine Reports

View full text Add to dashboard Cite

Perturbations in the levels of serotonin expression have a significant impact on behavior and have been implicated in the pathogenesis of several neuropsychiatric disorders including anxiety, mood and appetite. Fetal programming is a risk factor for the development of metabolic diseases during adulthood. Moreover, previous studies have shown that serotonin (5-HT), dopamine and leptin are important in energy balance. In the present study, the impact of maternal malnutrition-induced prenatal undernutrition (UN) was investigated in mice and the expression of 5-HT1A, dopamine (D)1, D2 and Ob-Rb receptors was analyzed in the hypothalamus during adulthood. The UN group showed a low birth weight compared with the control group. With regard to receptor expression, 5-HT1A in the UN group was increased in the hypothalamus and D1 was reduced, whereas D2 showed an increase from postnatal day (P)14 in the arcuate nucleus. Ob-Rb receptor expression was increased in the hypothalamus at P14 and P90. These observations indicated that maternal caloric restriction programs a postnatal body weight gain in offspring with an increased food intake in early postnatal life which continues into adulthood. In addition, UN in mice was found to be affected by Ob-Rb, 5-HT1A and D1/2 receptor expression, indicating that these observations may be associated with hyperphagia and obesity.

show abstract

Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation

Cited by 52 publications

References 40 publications

Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease

Impaired Decision Making and Loss of Inhibitory-Control in a Rat Model of Huntington Disease

Sexually Dimorphic Serotonergic Dysfunction in a Mouse Model of Huntington's Disease and Depression

Role of prenatal undernutrition in the expression of serotonin, dopamine and leptin receptors in adult mice: Implications of food intake

Contact Info

Product

Resources

About