Regional and Total-Body Perfusion of Malignant Tumours With Cytotoxic Drugs

Irvine, W. T.; Noon, Charles; Bastable, J. R. G.

doi:10.1016/s0140-6736(62)92362-0

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…As regional chemotherapy with an extracorporeal circuit developed, the local factors in 'This paper is a revised version of that by Irvine et al (1962) and Ls printed here by permission of the Editor of the Lancet this regional circulation came under study. Clearly the pressure in this circuit should be less than the systemic blood pressure to discourage leakage into the general circulation.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal Arterial Perfusion

1963

Proceedings of the Royal Society of Medicine

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Section: Discussionmentioning

confidence: 99%

Extracorporeal Arterial Perfusion

1963

Proceedings of the Royal Society of Medicine

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“…Techniques have been refined and indications of this method both in our hands4z1h and at many medical centers throughout the world have become more definite.?. R,o, [9][10][11]17919 This report summarizes our experience with regional perfusion during the past ten years and includes current indications for its use.…”

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confidence: 99%

Evaluation of chemotherapy of cancer by regional perfusion

Krementz

Creech

Ryan

1967

Cancer

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At Tulane Department of Surgery 597 patients with cancer have been perfused regionally 690 times—350 patients with melanoma, 164 with carcinoma and 83 with sarcoma. Early objective responses were noted in about 70% of patients with melanoma and in 60% with carcinoma and sarcoma. The duration of response in many instances was short whereas the expenditure of operating time and medical manpower was large. In poor‐risk patients with advanced disease the mortality rate was appreciable. In some patients, however, perfusion offered more than conventional therapy and is a valuable technique. In secondary melanoma—involvement of regional nodes, satellitosis or local recurrence—control has been obtained in 10 of 38 patients five years after perfusion. In primary melanoma confined to a limb the disease has been controlled in 10 of 11 patients five years after perfusion, conservative excision and node dissection. In sarcoma confined to the limbs perfusion and wide excision produced control of disease in 10 of 14 patients at five years. Perfusion as an adjunct to excision in patients with carcinoma adds little. Good palliation has been obtained in patients with a variety of malignant tumors by control of primary disease, even in the presence of systemic metastases.

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Cancer Chemotherapy and Autogenous Bone Marrow Transplant.

Pellegris

Caprio

1965

Tumori

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Thirty patients with widespread neoplastic disease have been treated with high doses of anticancer drugs. At the end of the treatment bone marrow previously drawn from the same patients and stored at -79 °C was reinfused. Different chemotherapeutic drugs were employed, mainly cyclophosphamide (17 cases) for a total dose of 100 mg/Kg, given during 10 days. Two patients died within a month because of toxic effects due to the treatment. In 13 cases a remarkable regression of the neoplastic lesions was observed, while in 10 cases the objective improvement was slight. Three patients are still clinically free of disease more than two years after treatment. The reinfusion of autologous bone marrow seems to favour the haematologic recovery and to avoid the more dangerous toxic effects of high doses of chemotherapy. The results so far obtained do not allow any conclusion on the definite therapeutic advantage of high dosage of anti-cancer drugs over the conventional doses, although remarkable results have been obtained in few patients.

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Regional and Total-Body Perfusion of Malignant Tumours With Cytotoxic Drugs

Cited by 5 publications

References 21 publications

Extracorporeal Arterial Perfusion

Extracorporeal Arterial Perfusion

Evaluation of chemotherapy of cancer by regional perfusion

Cancer Chemotherapy and Autogenous Bone Marrow Transplant.

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