We have read with great interest a recently published article in Acta Neurochirurgica by Song et al. entitled "Preemptive scalp infiltration with 0.5 % ropivacaine and 1 % lidocaine reduces postoperative pain after craniotomy" [5]. In this study, a cohort of 60 patients undergoing craniotomy was enrolled, and it was reported that preemptive administration of 0.5 % ropivacaine and 1 % lidocaine provided effective postoperative analgesia after craniotomy when compared to administration of the same solution before skin closure: the mean time to demand for postoperative analgesic was statistically delayed, less than half of the number of patients required morphine, and the median morphine consumption was less.Post-craniotomy pain is a recurrent complication of neurosurgical procedures and is difficult to manage. Pain management is of great importance to avoid complications such as hypertension and vomiting, which may lead to elevation in intracranial pressure, negative outcomes, and extended hospital stay. While Song et al. provide a good approach to mitigating post-craniotomy pain, this letter was written to explore other forms of post-craniotomy pain management. Dexmedetomidine demonstrates promise for pain management. Peng et al. analyzed the effect of intraoperative dexmedetomidine on post-craniotomy pain by analyzing a cohort of 76 patients [3]. One group of patients was given a p l a c e b o , a n d o n e g r o u p r e c e i v e d a c o n t i n u o u s dexmedetomidine infusion of 0.5 μg/kg/h. Pain scores, tramadol consumption, and postoperative nausea and vomiting (PONV) scores were measured within the first 24 h after surgery. Dexmedetomidine was reported to reduce pain scores, tramadol consumption, and PONV scores. Song et al. also corroborated these findings and demonstrated that dexmedetomidine infusion lowered pain scores within 12 h postoperatively when compared to placebo [4]. Patients given dexmedetomidine required 54.4, 43.3, and 31.4 % less morphine than the placebo group during the first 4, 12, and 24 h, respectively.Besides dexmedetomidine, sufentanil is another agent that shows promise for pain management. In a cohort of 45 patients, Hassani et al. analyzed how effective sufentanil and paracetamol were in comparison to morphine at controlling pain post-craniotomy [1]. A visual analog scale (VAS) pain score was used, and there was a significant difference in postoperative pain. The patients on sufentanil demonstrated the most relief from pain with the lowest VAS score. Sufentanil demonstrates better pain control, less nausea and vomiting, and better hemodynamic stability than morphine. Although paracetamol had fewer side effects of nausea and vomiting, it demonstrated the lowest amount of pain relief.While scalp anesthesia is the mainstay of treating craniotomy pain, Jayaram et al. tested the efficacy of bilateral maxillary block with a greater and lesser occipital nerve block to control craniotomy pain in a cohort of 40 patients [2]. The VAS pain score was used. At 12 h postoperation, the maxillary...